| 1. |  MrTorowing | 77 Curiosidades que seguramente desconocías de The Binding of Isaac | 7,535 | |
| 2. | DylanteroLive | ASÍ SI CTM -TBOIA+ -Ep 4 | 3,755 | |
| 3. | SOLOenVIVO | #Isaac en 1 minuto #4 #shorts | 573 | |
| 4. | Mr Smile | CUANTO CARIÑO HAY EN ESTE RAP | THE BINDING OF ISAAC (MACRO-RAP) | Mr Smile | 307 | |
| 5. | oliver6hallo | the binding of Isaac op items part 2 | 82 | |
| 6. | Don Indies | "Ésta será mi mejor obra" - Creador del The binding of Isaac | 81 | |
| 7. | luuiii1 | Salio justito #thebindingofisaac #vtuber #shorts | 70 | |
| 8. | Gorgonita Gaming | Gracias, no estoy loco #clipstwitch #shorts #twitchchile #gorgonita #thebindingofisaac | 54 | |
| 9. | LowDefinitionLD | Obsesión The Binding of Isaac | 50 | |
| 10. | PabloZX | Applecore pero un amigo y yo lo cantamos (but me and a friend sing it) | 36 | |
| 11. | T427 | worth #Shorts | 32 | |
| 12. | Pixelados | COMO DIBUJAR A ISAAC DE THE BINDING OF ISAAC EN PIXEL ART - PIXELADOS | 31 | |
| 13. | SOLOenVIVO | #Isaac en 1 minuto #5 #shorts | 25 | |
| 14. | T427 | 1st at today's daily run (two in a row) #Shorts | 24 | |
| 15. | Alejandro Cordero | The Binding of Isaac - Panchito me enseña a jugar | 21 | |
| 16. | T427 | The most annoying enemy in Isaac... it tooks 22 seconds to be defeated. #Shorts | 19 | |
| 17. | SOLOenVIVO | #Isaac en 1 minuto #6 #shorts | 16 | |
| 18. | T427 | perfection tragedy (tboi repentance daily run) #Shorts | 14 | |
| 19. | SOLOenVIVO | Bethany en 1 minuto #shorts | 13 | |
| 20. | Raccer | the binding of isaac drawing timelapse | 12 | |
| 21. | NimyFair | DEAD GOD!!! 100% DE REPENTANCE PARTIDAZA CON THE LOST!! / THE BINDING OF ISAAC AL 1001% Y MAS | 11 | |
| 22. | cronigal gaming | ⚔️ ¿TE ANIMAS a ENTRAR a estos 14 ADICTIVOS MUNDOS en 2D?⚔️ | 11 | |
| 23. | Fonlor | Cave Story's Secret Santa - The Binding of Isaac reference | 11 | |
| 24. | Raccer | Steamboat willy, Deep nightmare, Tboi etc! | Stream | 10 | |
| 25. | Hyper_Egret | 🔮 ¡Predicciones Locas y Jugadas Épicas! 🌟 ¡The Binding of Isaac en Directo! | 9 | |
| 26. | BrainSupremo | The Binding Of Isaac Aftherbirth - Ahora si empezamos bien-Cap1 | 9 | |
| 27. | T427 | easy win #Shorts | 8 | |
| 28. | IXIDoctorIXI | Cansansio del doctor - The binding of Isaac | 7 | |
| 29. | SOLOenVIVO | La sinergia belica. | 6 | |
| 30. | matriXx XD | SOY EL SEÑOR DE LAS MIERDAS | 6 | |
| 31. | drakul332 | The binding of isaac - respetance -- una buena run | 6 | |
| 32. | oliver6hallo | the binding of Isaac op items | 6 | |
| 33. | Temis | LA LISTA DE EMINEM | Temis | 6 | |
| 34. | MBlueYoshi | [💬] El Misterio Detrás de THE KEEPER - The Binding of Isaac | 8 | |
| 35. | ElStickman | The Binding Of Isaac | MAMA PORQUE! | Parte 1# | #StickProGames en español | 6 | |
| 36. | IXIDoctorIXI | No valgo nada aquí XD - Run diaria2 - The Binding of Isaac | 5 | |
| 37. | ivangamer_ tnt | Jugando al The Binding of Isaac de chil mientras estoy afk en una granja | 5 | |
| 38. | neurot | The Binding of Isaac es un videojuego independiente diseñado por Edmund McMillen | 5 | |
| 39. | D3im0ns | the binding of isaac aftervert + capitulo 1 | 5 | |
| 40. | RBTTIM | A normal run in The Binding of Isaac Repentace | 5 | |
| 41. | KrakerPaladio | Volvemos a jugar a este Juegazo - The binding of isaac Repetence (#4) | 5 | |
| 42. | Hoy Juego | #SHORT This is The Binding of Isaac | 5 | |
| 43. | RebelDYTR | the binding of isaac repentence completando challenges | 4 | |
| 44. | Amarovski | matando a megasatan el padre de t- judas | 4 | |
| 45. | IXIDoctorIXI | The Binding of Isaac:A+ Live - Una cosa rara tras otra | 4 | |
| 46. | Mapaxxxe | Directo | The Binding Of Isaac | Runs llenas de fracaso | #3 | 4 | |
| 47. | ElRetorMasCSM | Completando The Binding Of Isaac (depues de 3 intentos XDD) | 4 | |
| 48. | Hoy Juego | HOY JUEGO THE BINDING OF ISAAC | 4 | |
| 49. | Palteitor | The Binding of Isaac Wrath of the Lamb (Gurdy Jr) | 4 | |
| 50. | IXIDoctorIXI | Un juego normal... creo XD - The binding of Isaac | 4 | |
| 51. | IXIDoctorIXI | Run madrugadora - Run diaria 1 - The Binding of Isaac | 4 | |
| 52. | AsgarSinD | Primera run primera win (the binding of isaac) | 4 | |
| 53. | RebelDYTR | the binding of isaac repentence comtinuacion del episodio 2 | 4 | |
| 54. | ivangamer_ tnt | | The Binding of Isaac | Intentando sacarme hush o desbloquear polaroid. | 4 | |
| 55. | Piña Live | The Ultimate Binding of Brawhalla | Popurrí #2 (PiñaLive) | 4 | |
| 56. | IXIDoctorIXI | Doble Run :3 - The Binding Of Isaac | 3 | |
| 57. | RebelDYTR | the binding of isaac repentence capitulo 3 | 3 | |
| 58. | Black_Stark2 | My Best Attempt so far | The Binding of Isaac - Part 1 | 3 | |
| 59. | ElStickman | StickProGames vs Mama! | The Binding Of Isaac | Parte 2# | #StickProGames en español | 3 | |
| 60. | abysac | Buena partida, pero a que precio (The Binding Of Isaac: Repertance) | 3 | |
| 61. | D3im0ns | De lo roto pase a lo lamentable :c. | 3 | |
| 62. | Maycol Gamer 026 | MG026 MUGEN - Deadpool #19 vs. Isaac (OHMSBY) | 3 | |
| 63. | Palteitor | The Binding of Isaac: Wrath of the Lamb (Gurdy) | 3 | |
| 64. | HeySeken | El Inicio de Isaac / The Binding of Isaac Aferbirth | 3 | |
| 65. | T427 | SUPLEX Fan N°1 #Shorts | 3 | |
| 66. | Diseñando Videojuegos con CR | Shrine Warden - Gameplay - Godot 4 - Godot Wild Jam #58 - Ranked 2nd | 3 | |
| 67. | Masuku Batsu | 5 Consejos para The Binding of Isaac / Directo al grano | 3 | |
| 68. | IXIDoctorIXI | Mi historica run :o - RD 7 - The binding of Isaac | 3 | |
| 69. | RebelDYTR | the bending of isaac :repentence | 3 | |
| 70. | RebelDYTR | the binding of isaac | 3 | |
| 71. | KrakerPaladio | Top 5 de mis personajes Favoritos del The binding of isaac | 3 | |
| 72. | HyperShadic31 | jugando the binding of isaac (sin voz xD) | 3 | |
| 73. | KrakerPaladio | Jugando a The binding of isaac (Espero que youtube no me lo elimine :p) | 3 | |
| 74. | Black_Stark2 | A Dark Fantasy Bosh Rush RPG | Fowl Scourge Demo | 3 | |
| 75. | drakul332 | The Binding of Isaac primera run | 2 | |
| 76. | IXIDoctorIXI | Mejorando todos los días un poquito - Run Diaria 5 - The binding of Isaac | 2 | |
| 77. | Martox Thekiller | Hablando Sobre Los Furrys Mientras Juego The Binding Of Isaac Repentence | 2 | |
| 78. | El Ro Senpai | La Suerte No Esta De Mi Lado | The Binding Of Isaac | En Español | 2 | |
| 79. | neurot | Isaac en español, haciendo desafios | 2 | |
| 80. | matriXx XD | Un mono es mas inteligente que yo XD Binding of Isaac | 2 | |
| 81. | Mapaxxxe | Directo | The Binding Of Isaac | NUEVO DLC | #2 | 2 | |
| 82. | ALLAN Demoncryst | Voy a por The Lamb |The Binding of Isaac parte 1 | 1 | |
| 83. | IXIDoctorIXI | La run mas corta de la vida - Run diaria 4 - The binding of Isaac | 2 | |
| 84. | ElRetorMasCSM | The Binding Of Isaac #2 I devuelta al nivel 1 F :( | 2 | |
| 85. | IXIDoctorIXI | Normalmente Sub - Run Diaria 6 - The binding of Isaac | 2 | |
| 86. | Palteitor | The Binding of Isaac Wrath of the Lamb (Larry Jr) | 2 | |
| 87. | Jeriko Gamer | Final epico de "The binding of isaac" | 2 | |
| 88. | abysac | Una partida de locos con Azazel (The Binding Of Isaac Repertance) | 2 | |
| 89. | SCPSP | Desbloqueando mas cosas - The Binding Of Isaac Afterbirht+ | 2 | |
| 90. | Palteitor | The Binding of Isaac: Wrath of the Lamb (4 Jinetes - Hambruna) | 2 | |
| 91. | drakul332 | The binding of isaac - respetance -- Hasta el fin | 2 | |
| 92. | abysac | ¡ Puede ser que ahora si se logro ! (The Binding Of Isaac: Repertance) | 2 | |
| 93. | D3im0ns | Los pecados de Judas The binding of isaac afterbert plus. | 2 | |
| 94. | D3im0ns | Eden al fin conoce a Hush The binding of isaac afterbert plus | 2 | |
| 95. | abysac | Increible run con Blue Baby Gran enfrentamiento al final ( The Binding Of Isaac: Repertance) | 1 | |
| 96. | abysac | The Binding Of Isaac: Repertence is life is love :,3 | 1 | |
| 97. | MiguelDSouls | 2 horas de Issac donde no logro nada | 1 | |
| 98. | Shester | The Binding of Isaac #gaming #shorts #thebindingofisaac | 1 | |
| 99. | donk | The blind of isaac rebirth Capitulo 9 (Shaggy Online) | 1 | |
| 100. | RebelDYTR | the bending of isaac | 1 | |
