| 1. |  MrTorowing | 77 Curiosidades que seguramente desconocías de The Binding of Isaac | 256,097 | |
| 2. | DylanteroLive | ASÍ SI CTM -TBOIA+ -Ep 4 | 64,487 | |
| 3. | SOLOenVIVO | #Isaac en 1 minuto #4 #shorts | 6,676 | |
| 4. | Mr Smile | CUANTO CARIÑO HAY EN ESTE RAP | THE BINDING OF ISAAC (MACRO-RAP) | Mr Smile | 6,326 | |
| 5. | Don Indies | The Binding of Isaac fue un prototipo para Mewgenics!? #gaming #videojuegos #tboi | 4,826 | |
| 6. | ZalgoTheAnimator | The Lamb Vs Mutant Skeleton - Minecraft Animation | Mutant Beasts Vs The Binding of Isaac | 1,805 | |
| 7. | luuiii1 | Salio justito #thebindingofisaac #vtuber #shorts | 1,727 | |
| 8. | Don Indies | "Ésta será mi mejor obra" - Creador del The binding of Isaac | 1,621 | |
| 9. | oliver6hallo | the binding of Isaac op items part 2 | 1,479 | |
| 10. | T427 | worth #Shorts | 1,363 | |
| 11. | T427 | perfection tragedy (tboi repentance daily run) #Shorts | 1,108 | |
| 12. | PabloZX | Applecore pero un amigo y yo lo cantamos (but me and a friend sing it) | 1,085 | |
| 13. | Gorgonita Gaming | Gracias, no estoy loco #clipstwitch #shorts #twitchchile #gorgonita #thebindingofisaac | 1,078 | |
| 14. | Pixelados | COMO DIBUJAR A ISAAC DE THE BINDING OF ISAAC EN PIXEL ART - PIXELADOS | 991 | |
| 15. | Don Indies | Noticias Indies - 2da semana de Noviembre - The Binding of Isaac multiplayer | 810 | |
| 16. | T427 | easy win #Shorts | 677 | |
| 17. | T427 | 1st at today's daily run (two in a row) #Shorts | 631 | |
| 18. | T427 | The most annoying enemy in Isaac... it tooks 22 seconds to be defeated. #Shorts | 599 | |
| 19. | thebratixx | Todo un nivel para esto.... 🫥 - The binding of Isaac | 529 | |
| 20. | ChromeVt | 【 THE BINDING OF ISAAC 】ALGUIEN QUIERE PENSAR EN EL NIÑO?【Chrome Cottontail】 | 432 | |
| 21. | LowDefinitionLD | Obsesión The Binding of Isaac | 418 | |
| 22. | Don Indies | The Binding of Isaac con Multiplayer! || Nintendo vs Palworld || Juegos Indies de la semana | 413 | |
| 23. | SOLOenVIVO | #Isaac en 1 minuto #5 #shorts | 352 | |
| 24. | cronigal gaming | ⚔️ ¿TE ANIMAS a ENTRAR a estos 14 ADICTIVOS MUNDOS en 2D?⚔️ | 318 | |
| 25. | Palteitor | The Binding of Isaac Wrath of the Lamb (Gurdy Jr) | 220 | |
| 26. | SOLOenVIVO | #Isaac en 1 minuto #6 #shorts | 211 | |
| 27. | Palteitor | The Binding of Isaac: Wrath of the Lamb (4 Jinetes - Hambruna) | 199 | |
| 28. | oliver6hallo | una partida chill - the binding of isaac (wrath of the lamb) | 197 | |
| 29. | Alejandro Cordero | The Binding of Isaac - Panchito me enseña a jugar | 184 | |
| 30. | Lionibug | Today we defeat Satan for sure! - The Binding of Isaac (Hard mode) | 165 | |
| 31. | T427 | SUPLEX Fan N°1 #Shorts | 152 | |
| 32. | SOLOenVIVO | La sinergia belica. | 147 | |
| 33. | Palteitor | The Binding of Isaac: Wrath of the Lamb (Gurdy) | 129 | |
| 34. | SOLOenVIVO | Bethany en 1 minuto #shorts | 128 | |
| 35. | Lionibug | Some Isaac to start 2025!! - The Binding of Isaac (Hard mode) | 128 | |
| 36. | matriXx XD | SOY EL SEÑOR DE LAS MIERDAS | 121 | |
| 37. | oliver6hallo | the binding of Isaac op items | 120 | |
| 38. | Raccer | Steamboat willy, Deep nightmare, Tboi etc! | Stream | 114 | |
| 39. | MBlueYoshi | [💬] El Misterio Detrás de THE KEEPER - The Binding of Isaac | 113 | |
| 40. | Maycol Gamer 026 | MG026 MUGEN - Deadpool #19 vs. Isaac (OHMSBY) | 112 | |
| 41. | Raccer | the binding of isaac drawing timelapse | 108 | |
| 42. | NimyFair | DEAD GOD!!! 100% DE REPENTANCE PARTIDAZA CON THE LOST!! / THE BINDING OF ISAAC AL 1001% Y MAS | 96 | |
| 43. | Fonlor | Cave Story's Secret Santa - The Binding of Isaac reference | 94 | |
| 44. | Palteitor | The Binding of Isaac: Wrath of the Lamb (Monstro) | 93 | |
| 45. | Hoy Juego | #SHORT This is The Binding of Isaac | 93 | |
| 46. | LUCHO | The binding of isaac - isaac #1 | 92 | |
| 47. | Palteitor | The Binding of Isaac: Wrath of the Lamb (Gemini) | 88 | |
| 48. | LUCHO | The binding of isaac - isaac #2 | 77 | |
| 49. | Smokedani el guardia | The binding of isaac primera vez con Corderito | Guardia Vtuber | 71 | |
| 50. | Palteitor | The Binding of Isaac Wrath of the Lamb (Larry Jr) | 67 | |
| 51. | Hyper_Egret | 🔮 ¡Predicciones Locas y Jugadas Épicas! 🌟 ¡The Binding of Isaac en Directo! | 60 | |
| 52. | Diseñando Videojuegos con CR | Shrine Warden - Gameplay - Godot 4 - Godot Wild Jam #58 - Ranked 2nd | 58 | |
| 53. | abysac | ¡ Puede ser que ahora si se logro ! (The Binding Of Isaac: Repertance) | 58 | |
| 54. | RBTTIM | A normal run in The Binding of Isaac Repentace | 52 | |
| 55. | Idorno | Noche viciando al Isaac - The Binding of Isaac | 51 | |
| 56. | Palteitor | The Binding of Isaac: Wrath of the Lamb (Fistula) | 50 | |
| 57. | ElStickman | StickProGames vs Mama! | The Binding Of Isaac | Parte 2# | #StickProGames en español | 44 | |
| 58. | abysac | Buena partida, pero a que precio (The Binding Of Isaac: Repertance) | 43 | |
| 59. | Amarovski | matando a megasatan el padre de t- judas | 39 | |
| 60. | ivangamer_ tnt | | The Binding of Isaac | Intentando sacarme hush o desbloquear polaroid. | 39 | |
| 61. | LUCHO | The binding of isaac - todos los finales | 37 | |
| 62. | RebelDYTR | the binding of isaac | 37 | |
| 63. | Palteitor | The Binding of Isaac Wrath of the Lamb (La Viuda) | 35 | |
| 64. | Smokedani el guardia | The binding of isaac primera vez con Corderito | Guardia Vtuber | 35 | |
| 65. | LUCHO | The binding of isaac - isaac #3 (FINAL) | 35 | |
| 66. | ElStickman | The Binding Of Isaac | MAMA PORQUE! | Parte 1# | #StickProGames en español | 35 | |
| 67. | Temis | LA LISTA DE EMINEM | Temis | 33 | |
| 68. | Smokedani el guardia | Corde me enseña a jugar The binding of isaac primera vez | Guardia Vtuber | 32 | |
| 69. | IXIDoctorIXI | The Binding of Isaac:A+ Live - Una cosa rara tras otra | 30 | |
| 70. | KrakerPaladio | Jugando a The binding of isaac (Espero que youtube no me lo elimine :p) | 30 | |
| 71. | Masuku Batsu | 5 Consejos para The Binding of Isaac / Directo al grano | 29 | |
| 72. | donk | The blind of isaac rebirth Capitulo 9 (Shaggy Online) | 28 | |
| 73. | D3im0ns | the binding of isaac aftervert + capitulo 1 | 27 | |
| 74. | IXIDoctorIXI | La run mas corta de la vida - Run diaria 4 - The binding of Isaac | 25 | |
| 75. | ivangamer_ tnt | Jugando al The Binding of Isaac de chil mientras estoy afk en una granja | 24 | |
| 76. | abysac | Una partida de locos con Azazel (The Binding Of Isaac Repertance) | 24 | |
| 77. | MiguelDSouls | 2 horas de Issac donde no logro nada | 23 | |
| 78. | BrainSupremo | The Binding Of Isaac Aftherbirth - Ahora si empezamos bien-Cap1 | 23 | |
| 79. | abysac | Primera partida con Azazel en harcore ( The Binding Of Isaac: Repertence) | 23 | |
| 80. | Martox Thekiller | Hablando Sobre "Los Soldados Caídos" Mientras Juego The Binding Of Isaac Repetence | 22 | |
| 81. | abysac | The Binding Of Isaac: Repertence is life is love :,3 | 22 | |
| 82. | ElRetorMasCSM | Completando The Binding Of Isaac (depues de 3 intentos XDD) | 21 | |
| 83. | Ju3qu8n | The binding of isaac aftherbirth plus - modo greedier | 21 | |
| 84. | neurot | The Binding of Isaac es un videojuego independiente diseñado por Edmund McMillen | 21 | |
| 85. | HyperShadic31 | jugando the binding of isaac (sin voz xD) | 20 | |
| 86. | Ju3qu8n | The binding of Isaac aftherbirth plus - sotano | 20 | |
| 87. | Mariovegano | isaac-ng - Acceso directo PASANDO EN HARD | 19 | |
| 88. | KrakerPaladio | Top 5 de mis personajes Favoritos del The binding of isaac | 19 | |
| 89. | ElRetorMasCSM | The Binding Of Isaac #2 I devuelta al nivel 1 F :( | 19 | |
| 90. | 😁 Rad the slime 😁 | Jugando the binding of isaac en directo | #1 | Rad | 19 | |
| 91. | HeySeken | El Inicio de Isaac / The Binding of Isaac Aferbirth | 19 | |
| 92. | RebelDYTR | the binding of isaac repentence capitulo 3 | 18 | |
| 93. | abysac | Increible run con Blue Baby Gran enfrentamiento al final ( The Binding Of Isaac: Repertance) | 18 | |
| 94. | IXIDoctorIXI | Mi historica run :o - RD 7 - The binding of Isaac | 18 | |
| 95. | KrakerPaladio | Volvemos a jugar a este Juegazo - The binding of isaac Repetence (#4) | 17 | |
| 96. | IXIDoctorIXI | Doble Run :3 - The Binding Of Isaac | 17 | |
| 97. | drakul332 | El niño lagrima -- the binding of Isaac | 17 | |
| 98. | Piña Live | The Ultimate Binding of Brawhalla | Popurrí #2 (PiñaLive) | 16 | |
| 99. | Ju3qu8n | The binding of isaac aftherbirth plus - segunda partida | 16 | |
| 100. | Hoy Juego | HOY JUEGO THE BINDING OF ISAAC | 16 | |
