| 1. |  OfficialNerdCubed | Nerd³ Plays... The Binding of Isaac | 1,634 | Let's Play |
| 2. | Dan Does | How to Sculpt a Tiny Isaac (The Binding of Isaac) | 300 | Let's Play |
| 3. | Dan Does | How to Sculpt The Hollow (The Binding of Isaac) | 149 | Let's Play |
| 4. | Evanz111 | The Random Commentaries: Binding of Isaac | 129 | Let's Play |
| 5. | PyroJoe | PyroJoe Plays: The Binding Of Isaac! #2 | 125 | Let's Play |
| 6. | Storpey | Steve plays The Binding of Isaac (Storpey's Steam Stuff) | 123 | Let's Play |
| 7. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #1) 'Until Rebirth' | 108 | Let's Play |
| 8. | Dan Does | How to Make Lots of The Binding of Isaac Sculpts! | 88 | Let's Play |
| 9. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #35) 'Knife Cat' | 44 | Let's Play |
| 10. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #54) 'Brimstone Spider' | 43 | Let's Play |
| 11. | Eurogamer | Let's Play The Binding of Isaac - Late to the Party | 42 | Let's Play |
| 12. | Millbeeful | The Binding Of Isaac :: Let's Play Live (Episode #10) 'The Breaking Of Isaac' | 41 | Let's Play |
| 13. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #47) 'Devil's Reflection' | 40 | Let's Play |
| 14. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #41) 'Deja-Vu' | 37 | Let's Play |
| 15. | Millbeeful | The Binding Of Isaac :: Let's Play Live (Episode #9) 'Coming To You Live!' | 37 | Let's Play |
| 16. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #7) 'Angelic' | 36 | Let's Play |
| 17. | MrAndersonLP | The Binding of Isaac: Wrath of the Lamb Episode 0 - [Crapular] | 36 | Let's Play |
| 18. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #45) 'Burning Knife' | 33 | Let's Play |
| 19. | MrAndersonLP | Let's Play The Binding of Isaac Community Remix Mod [Episode 1] - Ludovico Technique | 32 | Let's Play |
| 20. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #42) 'The Chest' | 32 | Let's Play |
| 21. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #40) 'Knife Cyclops' | 32 | Let's Play |
| 22. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #37) 'Such a Win!' | 30 | Let's Play |
| 23. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #57) 'Nun's Nail' | 30 | Let's Play |
| 24. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Season 2 Episode 1 [Starting Over] | 30 | Let's Play |
| 25. | MrAndersonLP | Let's Play The Binding of Isaac Again [Episode 1] - TOM CRUISE | 30 | Let's Play |
| 26. | ParkyGames | Parky's Shorts - The Binding of Isaac - Part 1 - Slightly Disturbing | 29 | Let's Play |
| 27. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #51) 'No Knife Squad' | 29 | Let's Play |
| 28. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #39) ' The Eternal Meat Lord' | 28 | Let's Play |
| 29. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #55) 'Loki's Whore' | 27 | Let's Play |
| 30. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #52) 'Fez Demon' | 27 | Let's Play |
| 31. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #59) 'Isaac Was Good Today' | 27 | Let's Play |
| 32. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #46) 'Prayer Lust' | 26 | Let's Play |
| 33. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb [Episode 27] - GIANT PEE LASERS OF JUSTICE! | 25 | Let's Play |
| 34. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #60) 'Spirit Of Dr Fetus' | 25 | Let's Play |
| 35. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Season 2 Episode 7 [The Doctor's Revenge] | 25 | Let's Play |
| 36. | ParkyGames | Parky's Shorts - Wrath of The Lamb - Part 1 - Let's Do This! | 25 | Let's Play |
| 37. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #53) 'Redemption' | 25 | Let's Play |
| 38. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #44) 'Cain You Believe It?' | 24 | Let's Play |
| 39. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #3) 'Adventures In The Womb' | 24 | Let's Play |
| 40. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Episode 9 [Meat 4 Evar] | 24 | Let's Play |
| 41. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #2) 'Wind Trumpet' | 23 | Let's Play |
| 42. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Episode 21 [Yippee-Ki-Yay MotherFu**er] | 23 | Let's Play |
| 43. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #50) 'Dead Lust' | 23 | Let's Play |
| 44. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #38) 'Flying Laser Cat' | 22 | Let's Play |
| 45. | MrAndersonLP | Let's Play The Binding of Isaac Community Remix Mod [Episode 2] - Temptation | 22 | Let's Play |
| 46. | MrAndersonLP | Let's Play The Binding of Isaac Community Remix Mod [Episode 4] - My Luckiest Run Ever? | 22 | Let's Play |
| 47. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #5) 'The Garden Of Eve' | 21 | Let's Play |
| 48. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #6) 'High Risk Strategy' | 20 | Let's Play |
| 49. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #4) 'The Guppy Effect' | 20 | Let's Play |
| 50. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #58) 'Dad's Spirit' | 20 | Let's Play |
| 51. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #43) 'Hard Hitting Choke' | 19 | Let's Play |
| 52. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #56) 'Goofball Run' | 19 | Let's Play |
| 53. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Episode 22 [E3 2013 Talk] | 19 | Let's Play |
| 54. | RobinLSL | Let's Play The Binding of Isaac - 1 - Discovery | 19 | Let's Play |
| 55. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Episode 17 [Pussinator] | 18 | Let's Play |
| 56. | Chawesy | THE CAT MURDERED MY MOM | Cat Evolution : Alpaca Zombie! | Gameplay, Reaction | 18 | Let's Play |
| 57. | Millbeeful | The Binding Of Isaac :: Let's Play Live (Episode #13) 'Nails & Hearts' | 17 | Let's Play |
| 58. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb (Custom Challenges) - Episode 8 [Sick Cat] | 17 | Let's Play |
| 59. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #32) 'Pro Skills' | 17 | Let's Play |
| 60. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Season 2 Episode 2 [Isaac VS Moms Heart] | 17 | Let's Play |
| 61. | Millbeeful | The Binding Of Isaac :: Let's Play Live (Episode #14) 'In Search Of Rambo' | 17 | Let's Play |
| 62. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #49) 'Candle Poop' | 16 | Let's Play |
| 63. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #48) 'Peepers Cat' | 15 | Let's Play |
| 64. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #34) 'Sleepless In Isaac' | 15 | Let's Play |
| 65. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Season 2 Episode 6 [29 Seconds] | 15 | Let's Play |
| 66. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Episode 13 [REAL Large Marge] | 15 | Let's Play |
| 67. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #33) 'Tank Dance' | 15 | Let's Play |
| 68. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb [Episode 28] - THANKS PHIL! | 15 | Let's Play |
| 69. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #36) 'Explosive Fetus Head' | 14 | Let's Play |
| 70. | TrU3Ta1ent | Let's play The Binding of Isaac with hilarious commentary [part 1] FIRST RUN! | 14 | Let's Play |
| 71. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #31) 'Epic Eve' | 14 | Let's Play |
| 72. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Episode 16 [Quest for The Polaroid] | 14 | Let's Play |
| 73. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Episode 18 [Insert Witty Title Here] | 14 | Let's Play |
| 74. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb [Episode 25] - Cain Is OP | 13 | Let's Play |
| 75. | MrAndersonLP | Let's Play The Binding of Isaac Again [Episode 10] - Mr Freeze | 13 | Let's Play |
| 76. | Millbeeful | The Binding Of Isaac :: Let's Play Live (Episode #12) 'So Tense!' | 13 | Let's Play |
| 77. | MrAndersonLP | Let's Play The Binding of Isaac Community Remix Mod [Episode 5] - Blue Man Group | 13 | Let's Play |
| 78. | Millbeeful | The Binding Of Isaac | SHAKE OFF THE RUST - Millbee's Playthrough Part 46 | 12 | Let's Play |
| 79. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #8) 'Judas The Glass Cannon' | 12 | Let's Play |
| 80. | MrAndersonLP | Let's Play The Binding of Isaac: New Save File (Gameplay/Walkthrough) [Part 2] | 12 | Let's Play |
| 81. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb (Custom Challenges) - Episode 10 [John Lennon] | 11 | Let's Play |
| 82. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb [Episode 24] - 9 Deaths | 11 | Let's Play |
| 83. | Steejo | 100%ing The Binding of Isaac With Steejo - Episode 1 | 10 | Let's Play |
| 84. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Season 2 Episode 5 [Spider-Boy] | 10 | Let's Play |
| 85. | MrAndersonLP | Let's Play The Binding of Isaac Again [Episode 2] - MISSION IMPROBABLE | 10 | Let's Play |
| 86. | MrAndersonLP | Let's Play The Binding of Isaac Again [Episode 9] - Undone | 10 | Let's Play |
| 87. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Episode 11 [Judas vs The Cathedral] | 10 | Let's Play |
| 88. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Season 2 Episode 4 [Maggy VS Sheol] | 9 | Let's Play |
| 89. | MrAndersonLP | Let's Play The Binding of Isaac Again [Episode 3] - BROCK LESNAR | 9 | Let's Play |
| 90. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb [Episode 23] - Sacred Balls | 9 | Let's Play |
| 91. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Episode 14 [7 Years Bad Luck] | 9 | Let's Play |
| 92. | MrAndersonLP | Let's Play The Binding of Isaac Again [Episode 12] - Quest | 9 | Let's Play |
| 93. | Millbeeful | The Binding Of Isaac :: Let's Play Live (Episode #11) 'Cain's Luck Runs Out' | 8 | Let's Play |
| 94. | MrAndersonLP | Let's Play The Binding of Isaac Again [Episode 6] - MY MOST POWERFUL RUN EVER? | 8 | Let's Play |
| 95. | MrAndersonLP | Let's Play The Binding of Isaac Again [Episode 5] - BLUE BASTARD | 8 | Let's Play |
| 96. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Episode 20 [Wife Beater] | 8 | Let's Play |
| 97. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Episode 15 [Cain vs The Cathedral] | 8 | Let's Play |
| 98. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Season 2 Episode 3 [Dark Was The Night] | 8 | Let's Play |
| 99. | MrAndersonLP | Let's Play The Binding of Isaac Community Remix Mod [Episode 3] - Tiny Planet 1/2 | 8 | Let's Play |
| 100. | ParkyGames | An Evening Playing: The Binding of Isaac | 8 | Let's Play |
