| 1. |  OfficialNerdCubed | Nerd³ Plays... The Binding of Isaac | 893,392 | Let's Play |
| 2. | Eurogamer | Let's Play The Binding of Isaac - Late to the Party | 28,198 | Let's Play |
| 3. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #1) 'Until Rebirth' | 15,442 | Let's Play |
| 4. | Dan Does | How to Sculpt a Tiny Isaac (The Binding of Isaac) | 11,103 | Let's Play |
| 5. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Episode 13 [REAL Large Marge] | 9,154 | Let's Play |
| 6. | Storpey | Steve plays The Binding of Isaac (Storpey's Steam Stuff) | 8,781 | Let's Play |
| 7. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #2) 'Wind Trumpet' | 8,145 | Let's Play |
| 8. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #7) 'Angelic' | 7,999 | Let's Play |
| 9. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #3) 'Adventures In The Womb' | 7,825 | Let's Play |
| 10. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #4) 'The Guppy Effect' | 7,782 | Let's Play |
| 11. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #5) 'The Garden Of Eve' | 7,406 | Let's Play |
| 12. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #41) 'Deja-Vu' | 7,256 | Let's Play |
| 13. | Millbeeful | The Binding Of Isaac :: Let's Play Live (Episode #12) 'So Tense!' | 6,732 | Let's Play |
| 14. | Millbeeful | The Binding Of Isaac :: Let's Play Live (Episode #9) 'Coming To You Live!' | 6,731 | Let's Play |
| 15. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #50) 'Dead Lust' | 6,720 | Let's Play |
| 16. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #40) 'Knife Cyclops' | 6,580 | Let's Play |
| 17. | MrAndersonLP | Let's Play The Binding of Isaac Community Remix Mod [Episode 1] - Ludovico Technique | 6,562 | Let's Play |
| 18. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #44) 'Cain You Believe It?' | 6,361 | Let's Play |
| 19. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #54) 'Brimstone Spider' | 6,357 | Let's Play |
| 20. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #47) 'Devil's Reflection' | 6,329 | Let's Play |
| 21. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #60) 'Spirit Of Dr Fetus' | 6,301 | Let's Play |
| 22. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #45) 'Burning Knife' | 6,211 | Let's Play |
| 23. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #46) 'Prayer Lust' | 6,152 | Let's Play |
| 24. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #42) 'The Chest' | 6,021 | Let's Play |
| 25. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #39) ' The Eternal Meat Lord' | 5,986 | Let's Play |
| 26. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #55) 'Loki's Whore' | 5,775 | Let's Play |
| 27. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #49) 'Candle Poop' | 5,744 | Let's Play |
| 28. | Millbeeful | The Binding Of Isaac :: Let's Play Live (Episode #13) 'Nails & Hearts' | 5,720 | Let's Play |
| 29. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #37) 'Such a Win!' | 5,641 | Let's Play |
| 30. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #33) 'Tank Dance' | 5,353 | Let's Play |
| 31. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #53) 'Redemption' | 5,345 | Let's Play |
| 32. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #57) 'Nun's Nail' | 5,311 | Let's Play |
| 33. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #38) 'Flying Laser Cat' | 5,301 | Let's Play |
| 34. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #48) 'Peepers Cat' | 5,256 | Let's Play |
| 35. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #6) 'High Risk Strategy' | 5,241 | Let's Play |
| 36. | Millbeeful | The Binding Of Isaac :: Let's Play Live (Episode #14) 'In Search Of Rambo' | 5,231 | Let's Play |
| 37. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #58) 'Dad's Spirit' | 5,230 | Let's Play |
| 38. | Millbeeful | The Binding Of Isaac :: Let's Play Live (Episode #10) 'The Breaking Of Isaac' | 5,179 | Let's Play |
| 39. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #8) 'Judas The Glass Cannon' | 5,136 | Let's Play |
| 40. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #51) 'No Knife Squad' | 5,014 | Let's Play |
| 41. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #52) 'Fez Demon' | 4,905 | Let's Play |
| 42. | Chawesy | THE CAT MURDERED MY MOM | Cat Evolution : Alpaca Zombie! | Gameplay, Reaction | 4,788 | Let's Play |
| 43. | Dan Does | How to Sculpt The Hollow (The Binding of Isaac) | 4,787 | Let's Play |
| 44. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #43) 'Hard Hitting Choke' | 4,765 | Let's Play |
| 45. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #56) 'Goofball Run' | 4,749 | Let's Play |
| 46. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #59) 'Isaac Was Good Today' | 4,746 | Let's Play |
| 47. | Millbeeful | The Binding Of Isaac :: Let's Play Live (Episode #11) 'Cain's Luck Runs Out' | 4,719 | Let's Play |
| 48. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #36) 'Explosive Fetus Head' | 4,686 | Let's Play |
| 49. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #35) 'Knife Cat' | 4,290 | Let's Play |
| 50. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #34) 'Sleepless In Isaac' | 4,288 | Let's Play |
| 51. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #31) 'Epic Eve' | 4,007 | Let's Play |
| 52. | Millbeeful | The Binding Of Isaac :: Let's Play (Episode #32) 'Pro Skills' | 3,693 | Let's Play |
| 53. | Dan Does | How to Make Lots of The Binding of Isaac Sculpts! | 3,404 | Let's Play |
| 54. | MrAndersonLP | Let's Play The Binding of Isaac Again [Episode 1] - TOM CRUISE | 2,410 | Let's Play |
| 55. | Millbeeful | The Binding Of Isaac | SHAKE OFF THE RUST - Millbee's Playthrough Part 46 | 2,360 | Let's Play |
| 56. | Evanz111 | The Random Commentaries: Binding of Isaac | 2,249 | Let's Play |
| 57. | MrAndersonLP | The Binding of Isaac: Wrath of the Lamb Episode 0 - [Crapular] | 2,130 | Let's Play |
| 58. | ParkyGames | Parky's Shorts - The Binding of Isaac - Part 1 - Slightly Disturbing | 1,886 | Let's Play |
| 59. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Season 2 Episode 1 [Starting Over] | 1,872 | Let's Play |
| 60. | PyroJoe | PyroJoe Plays: The Binding Of Isaac! #2 | 1,735 | Let's Play |
| 61. | Steejo | 100%ing The Binding of Isaac With Steejo - Episode 1 | 1,600 | Let's Play |
| 62. | ParkyGames | Parky's Shorts - Wrath of The Lamb - Part 1 - Let's Do This! | 1,389 | Let's Play |
| 63. | TrU3Ta1ent | Let's play The Binding of Isaac with hilarious commentary [part 1] FIRST RUN! | 1,353 | Let's Play |
| 64. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Season 2 Episode 2 [Isaac VS Moms Heart] | 1,221 | Let's Play |
| 65. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb (Custom Challenges) - Episode 10 [John Lennon] | 1,148 | Let's Play |
| 66. | MrAndersonLP | Let's Play The Binding of Isaac Again [Episode 2] - MISSION IMPROBABLE | 1,138 | Let's Play |
| 67. | MrAndersonLP | Let's Play The Binding of Isaac: New Save File (Gameplay/Walkthrough) [Part 1] | 1,099 | Let's Play |
| 68. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Episode 14 [7 Years Bad Luck] | 988 | Let's Play |
| 69. | MrAndersonLP | Let's Play The Binding of Isaac Community Remix Mod [Episode 2] - Temptation | 981 | Let's Play |
| 70. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Season 2 Episode 7 [The Doctor's Revenge] | 976 | Let's Play |
| 71. | MrAndersonLP | Let's Play The Binding of Isaac Again [Episode 6] - MY MOST POWERFUL RUN EVER? | 930 | Let's Play |
| 72. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb (Custom Challenges) - Episode 8 [Sick Cat] | 903 | Let's Play |
| 73. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Season 2 Episode 4 [Maggy VS Sheol] | 896 | Let's Play |
| 74. | MrAndersonLP | Let's Play The Binding of Isaac Again [Episode 4] - ONE SHOT | 895 | Let's Play |
| 75. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Episode 12 [Blue Baby vs The Cathedral] | 864 | Let's Play |
| 76. | MrAndersonLP | Let's Play The Binding of Isaac Again [Episode 3] - BROCK LESNAR | 849 | Let's Play |
| 77. | MrAndersonLP | Let's Play The Binding of Isaac Community Remix Mod [Episode 4] - My Luckiest Run Ever? | 840 | Let's Play |
| 78. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Season 2 Episode 6 [29 Seconds] | 839 | Let's Play |
| 79. | MrAndersonLP | Let's Play The Binding of Isaac Again [Episode 7] - ACE OF SPADES | 823 | Let's Play |
| 80. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Season 2 Episode 3 [Dark Was The Night] | 822 | Let's Play |
| 81. | MrAndersonLP | Let's Play The Binding of Isaac Community Remix Mod [Episode 3] - Tiny Planet 2/2 | 816 | Let's Play |
| 82. | MrAndersonLP | Let's Play The Binding of Isaac Again [Episode 5] - BLUE BASTARD | 804 | Let's Play |
| 83. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Episode 11 [Judas vs The Cathedral] | 776 | Let's Play |
| 84. | RobinLSL | Let's Play The Binding of Isaac - 1 - Discovery | 766 | Let's Play |
| 85. | MrAndersonLP | Let's Play The Binding of Isaac Community Remix Mod [Episode 3] - Tiny Planet 1/2 | 755 | Let's Play |
| 86. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Episode 15 [Cain vs The Cathedral] | 736 | Let's Play |
| 87. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Season 2 Episode 5 [Spider-Boy] | 733 | Let's Play |
| 88. | MrAndersonLP | Let's Play The Binding of Isaac Community Remix Mod [Episode 5] - Blue Man Group | 672 | Let's Play |
| 89. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Episode 9 [Meat 4 Evar] | 663 | Let's Play |
| 90. | MrAndersonLP | Let's Play The Binding of Isaac Again [Episode 8] - Rod Stewart | 661 | Let's Play |
| 91. | MrAndersonLP | Let's Play The Binding of Isaac Again [Episode 11] - Champions Challenge (Challenge Run) | 653 | Let's Play |
| 92. | MrAndersonLP | Let's Play The Binding of Isaac Again [Episode 10] - Mr Freeze | 653 | Let's Play |
| 93. | Jaru | TROLL ROOMS:The Binding of Isaac Let's Play w/Jaru Part 1 | 641 | Let's Play |
| 94. | MrAndersonLP | Let's Play The Binding of Isaac Again [Episode 9] - Undone | 632 | Let's Play |
| 95. | PieDragonPS | The Binding of Isaac [Glitch] - 9 Lives = Lots of Boss Items | 632 | Let's Play |
| 96. | MrAndersonLP | Let's Play The Binding of Isaac Again [Episode 12] - Quest | 631 | Let's Play |
| 97. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Episode 18 [Insert Witty Title Here] | 604 | Let's Play |
| 98. | JustRed | The Binding of Isaac | Wrath of the Lamb Playthrough | 600 | Let's Play |
| 99. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Episode 21 [Yippee-Ki-Yay MotherFu**er] | 583 | Let's Play |
| 100. | MrAndersonLP | Let's Play The Binding of Isaac: Wrath of the Lamb - Episode 20 [Wife Beater] | 547 | Let's Play |
