| 1. |  OfficialNerdCubed | Nerd³ Plays... The Binding of Isaac - Afterbirth+ | 696 | Let's Play |
| 2. | Mr Samuel Streamer | Tutorial/Introduction to the Binding of Isaac (ft God Awful Run) | Binding of Isaac: Repentance #1 | 219 | Let's Play |
| 3. | TearofGrace | WITCHER 3/GERALT MOD (a whole new playstyle) | The Binding of Isaac: AFTERBIRTH PLUS | 214 | Let's Play |
| 4. | Mr Samuel Streamer | Keys, Bombs, and Hearts + Moving Channels! | Binding of Isaac: Repentance #4 | 196 | Let's Play |
| 5. | Millbeeful | The Binding Of Isaac: Rebirth :: The Start (Episode #1) {Let's Play} | 133 | Let's Play |
| 6. | Mr Samuel Streamer | Crying My Way Through New Content | Binding of Isaac: Repentance #2 | 126 | Let's Play |
| 7. | Pedguin | Afterbirth Seed: Mage Playthrough | 112 | Let's Play |
| 8. | Neo Rambler | Let's Play The Binding Of Isaac (Rebirth) Blind (PC): Part 1 | 65 | Let's Play |
| 9. | Mr Samuel Streamer | New Final Boss? What ARE You? | Binding of Isaac: Repentance #3 | 61 | Let's Play |
| 10. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 2 (With Chat) | 60 | Let's Play |
| 11. | Millbeeful | Absolute Power | The Binding of Isaac: Afterbirth+ - Millbee Plays [Episode 44] | 59 | Let's Play |
| 12. | TheTurtleMelon | REPENTANCE IS HERE!! - Let's Play The Binding of Isaac Repentance - Part 1 | 59 | Let's Play |
| 13. | TheTurtleMelon | 100s OF NEW ITEMS, ROOMS AND ENEMIES! - Mega Modded The Binding of Isaac Repentance - Part 1 | 58 | Let's Play |
| 14. | TheTurtleMelon | What is The Binding of Isaac Nuzlocke? (Introduction and First Run) | 57 | Let's Play |
| 15. | Neo Rambler | Let's Play The Binding Of Isaac Afterbirth Blind (PC): Part 3 | 57 | Let's Play |
| 16. | Evanz111 | evunz plays binding of isaac rebirth | 56 | Let's Play |
| 17. | YetiHype | Binding of Isaac: Rebirth - sheol setseed Speedrun in 9:39 - Azazel Former WR | 56 | Let's Play |
| 18. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 1 (With Chat) | 55 | Let's Play |
| 19. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Episode 1 [Beginnings] | 55 | Let's Play |
| 20. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Episode 3 [Satan] | 53 | Let's Play |
| 21. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 18 (With Chat) | 52 | Let's Play |
| 22. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 15 (With Chat) | 51 | Let's Play |
| 23. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 17 (With Chat) | 50 | Let's Play |
| 24. | Millbeeful | The Binding Of Isaac: Afterbirth - Millbee Plays - Episode 25 [Lilith] | 48 | Let's Play |
| 25. | Millbeeful | The Binding Of Isaac: Afterbirth - Millbee Plays - Episode 32 [Skull Face] | 48 | Let's Play |
| 26. | TheTurtleMelon | THREE ROWS OF HEALTH??? - Mega Modded The Binding of Isaac Repentance - Part 9 | 48 | Let's Play |
| 27. | Flik's Gaming Stuff | The Binding of Isaac: Antibirth | Guest Episode | GrinningOwl | 46 | Let's Play |
| 28. | TheTurtleMelon | SO MUCH PAIN! - Let's Play The Binding of Isaac Repentance - Part 102 | 44 | Let's Play |
| 29. | TheTurtleMelon | Just....Damage....I Dont Even Know..... | 44 | Let's Play |
| 30. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 22 (With Chat) | 43 | Let's Play |
| 31. | Neo Rambler | Let's Play The Binding Of Isaac Afterbirth Blind (PC): Part 4 | 43 | Let's Play |
| 32. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 20 (With Chat) | 43 | Let's Play |
| 33. | Neo Rambler | Let's Play The Binding Of Isaac Afterbirth Blind (PC): Part 9 | 43 | Let's Play |
| 34. | TheTurtleMelon | THE CLOSEST BOSS RUSH EVER! - Let's Play The Binding of Isaac Repentance - Part 65 | 42 | Let's Play |
| 35. | apqLIVE | It's finally time for HARD MODE! (send help pls) | The Binding of Isaac: Repentance | 42 | Let's Play |
| 36. | Flik's Gaming Stuff | The Binding of Isaac: Antibirth | Part 17 | "Isaac's Awakening" | 42 | Let's Play |
| 37. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 13 (With Chat) | 42 | Let's Play |
| 38. | TheTurtleMelon | SANGUINE BOND IS GOOD NOW??? - Mega Modded The Binding of Isaac Repentance - Part 24 | 41 | Let's Play |
| 39. | TheTurtleMelon | TAKING RISKS I CANNOT BE TAKING!! - Modlocke Practice The Binding of Isaac Repentance - Part 1 | 41 | Let's Play |
| 40. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 3 (With Chat) | 41 | Let's Play |
| 41. | TheTurtleMelon | LET THE RANDOM STREAKS BEGIN....KINDA...- Random Streaking The Binding of Isaac Repentance - Part 1 | 41 | Let's Play |
| 42. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Episode 7 [Big Man] | 40 | Let's Play |
| 43. | Neo Rambler | Let's Play The Binding Of Isaac Afterbirth Blind (PC): Part 5 | 40 | Let's Play |
| 44. | TheTurtleMelon | HOLY DIAMOND IPECAC!! - Let's Play The Binding of Isaac Repentance - Part 107 | 40 | Let's Play |
| 45. | 2 old 4 gaming | Binding of Isaac PSVita Physical Copy Discovered and History of Nicalis PS Vita Physical Releases | 39 | Let's Play |
| 46. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Episode 5 [Distraction] | 39 | Let's Play |
| 47. | TheTurtleMelon | DEAD GOD ACHIEVED!! - Let's Play The Binding of Isaac Repentance | 38 | Let's Play |
| 48. | TheTurtleMelon | THE BEST START TO A SERIES IN HISTORY - Dead God Plus: A Tale of Two Lukes - Part 1 | 38 | Let's Play |
| 49. | TheTurtleMelon | The Binding of Isaac Afterbirth+ - Part 1 - [Basement] | 38 | Let's Play |
| 50. | TheTurtleMelon | 2 LEFT THUMBS CO-OP GOD RUN!! - Let's CO-OP The Binding of Isaac Repentance - Part 3 | 37 | Let's Play |
| 51. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Episode 2 [Greed] | 37 | Let's Play |
| 52. | TheTurtleMelon | THE BEST START TO A RUN!?- Let's Play The Binding of Isaac Repentance - Part 55 | 37 | Let's Play |
| 53. | TheTurtleMelon | TURTLEMELON WANT COIN!!! - Let's Play The Binding of Isaac Repentance - Part 49 | 37 | Let's Play |
| 54. | TheTurtleMelon | FETUS WITH A SWORD?!?!? - Let's Play The Binding of Isaac Repentance - Part 70 | 36 | Let's Play |
| 55. | TheTurtleMelon | (Stream VOD) WAKA WAKA - The Binding of Isaac Nuzlocke - Stream 1 (starts at 19:38) | 36 | Let's Play |
| 56. | TheTurtleMelon | CRAFTING AGAIN BUT NOW I KNOW HOW TO DO IT! - Let's Play The Binding of Isaac Repentance - Part 46 | 36 | Let's Play |
| 57. | Millbeeful | Millbee explains Shrinks | The Binding of Isaac: Afterbirth+ - Episode 6 | 36 | Let's Play |
| 58. | TheTurtleMelon | UNLEASHING GLYPH'S HIDDEN POWER! - Let's Play The Binding of Isaac Repentance - Part 81 | 36 | Let's Play |
| 59. | TheTurtleMelon | BREAKING DARK ESAU! - Let's Play The Binding of Isaac Repentance - Part 80 | 36 | Let's Play |
| 60. | TheTurtleMelon | OH NO WHAT DID I DO - Let's Play The Binding of Isaac Repentance - Part 72 | 35 | Let's Play |
| 61. | TheTurtleMelon | FLY BOY! - Mega Modded The Binding of Isaac Repentance - Part 11 | 35 | Let's Play |
| 62. | TheTurtleMelon | I MADE A MOD! - Rare Secret Rooms! - Mod Showcase | 35 | Let's Play |
| 63. | TheTurtleMelon | THE CRAZIEST CHARACTER IN THE GAME! - Let's Play The Binding of Isaac Repentance - Part 42 | 34 | Let's Play |
| 64. | MrAndersonLP | Let's Play The Binding of Isaac: Rebirth [Episode 4] - Eden | 34 | Let's Play |
| 65. | TheTurtleMelon | IPECAC COMMUNITY MOD! - Mega Modded The Binding of Isaac Repentance - Part 4 | 34 | Let's Play |
| 66. | TheTurtleMelon | THE HARDEST CHARACTER IN REPENTANCE! - Let's Play The Binding of Isaac Repentance - Part 48 | 34 | Let's Play |
| 67. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Episode 6 [Raining Steve] | 34 | Let's Play |
| 68. | TheTurtleMelon | NEW CHARACTER RANDOMISER TO DELIRIUM!! - Let's Play The Binding of Isaac Repentance - Part 145 | 34 | Let's Play |
| 69. | TheTurtleMelon | SO MANY COOL AF SYNERGIES!! - Let's Play The Binding of Isaac Repentance - Part 89 | 33 | Let's Play |
| 70. | TVR | The House in Fata Morgana / Chapter 3 (PS Vita Gameplay) | 33 | Let's Play |
| 71. | TheTurtleMelon | MEGA MODDED CO-OP! ft. @bd1pLP | 33 | Let's Play |
| 72. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Episode 8 [Hush] | 33 | Let's Play |
| 73. | Millbeeful | The Binding Of Isaac: Afterbirth - Millbee Plays - Episode 28 [Sacrifice] | 33 | Let's Play |
| 74. | Millbeeful | The Binding Of Isaac: Afterbirth - Millbee Plays - Episode 45 [Fecal Static] | 33 | Let's Play |
| 75. | MrAndersonLP | I BROKE THE GAME! ALL ITEMS - The Binding of Isaac: Afterbirth LIVE Let's Play [Episode 4] | 32 | Let's Play |
| 76. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 5 (With Chat) | 32 | Let's Play |
| 77. | Commodore Grayum | R KEY TO THE WITNESS | The Binding of Isaac ANTIBIRTH | Ep 79 | Modded let's play | 32 | Let's Play |
| 78. | Flik's Gaming Stuff | The Binding of Isaac: Antibirth | Part 36 | "Don't Acknowledge The Bin" | 32 | Let's Play |
| 79. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 16 | 32 | Let's Play |
| 80. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 19 (With Chat) | 32 | Let's Play |
| 81. | MrAndersonLP | Let's Play The Binding of Isaac: Rebirth [Episode 19] - Foreshadow | 32 | Let's Play |
| 82. | TheTurtleMelon | RUN RUN HECKIN RUN! - Let's Play The Binding of Isaac Repentance - Part 56 | 32 | Let's Play |
| 83. | TheTurtleMelon | WHO IS MASTEMA? - Repentance Modded Character Showcase | 32 | Let's Play |
| 84. | Unofficial Nerdcubed Live! - Livestream Archive | Nerd³ Plays Isaac At 5am - Binding of Isaac Afterbirth+ - 18th September 2017 | 32 | Let's Play |
| 85. | Flik's Gaming Stuff | The Binding of Isaac: Antibirth | Part 28 | "The Sweet Saga of Maggy IV" | 32 | Let's Play |
| 86. | MrAndersonLP | Let's Play The Binding of Isaac: Rebirth [Episode 17] - The Golden Door | 32 | Let's Play |
| 87. | TheTurtleMelon | INSANE DPS!! - Random Streaking The Binding of Isaac Repentance - Part 11 | 31 | Let's Play |
| 88. | TheTurtleMelon | SUPER OP MOD COMBO! - Mega Modded The Binding of Isaac Repentance - Part 13 | 31 | Let's Play |
| 89. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 4 (With Chat) | 31 | Let's Play |
| 90. | Foreman Plays Stuff | He's A Bleeder! | The Binding Of Isaac - Foreman Plays Stuff | 31 | Let's Play |
| 91. | Millbeeful | The Binding Of Isaac: Afterbirth - Millbee Plays - Episode 39 [Fecality] | 31 | Let's Play |
| 92. | TheTurtleMelon | BUILDING THE KNIFE - Let's Play The Binding of Isaac Repentance - Part 2 | 31 | Let's Play |
| 93. | Flik's Gaming Stuff | The Binding of Isaac: Antibirth | Part 37 | "Worth The Wait" | 31 | Let's Play |
| 94. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Episode 24 [Cardiovascular] | 31 | Let's Play |
| 95. | Neo Rambler | Let's Play The Binding Of Isaac (Afterbirth) Blind (PC): Part 2 | 31 | Let's Play |
| 96. | TheTurtleMelon | SUPLEX!!!!!!! - Let's Play The Binding of Isaac Repentance - Part 58 | 30 | Let's Play |
| 97. | TheTurtleMelon | MONEY RAIN! - Mega Modded The Binding of Isaac Repentance - Part 5 | 30 | Let's Play |
| 98. | TheTurtleMelon | BETHANY SOO FUN! - Let's Play The Binding of Isaac Repentance - Part 5 | 30 | Let's Play |
| 99. | TheTurtleMelon | ABSOLUTE HAVOC!! - Mega Modded The Binding of Isaac Repentance - Part 115 | 30 | Let's Play |
| 100. | TheTurtleMelon | R KEY FINALLLY!!!! - Let's Play The Binding of Isaac Repentance - Part 157 | 30 | Let's Play |
