| 1. |  OfficialNerdCubed | NerdΒ³ Plays... The Binding of Isaac - Afterbirth+ | 308,933 | Let's Play |
| 2. | TearofGrace | WITCHER 3/GERALT MOD (a whole new playstyle) | The Binding of Isaac: AFTERBIRTH PLUS | 199,554 | Let's Play |
| 3. | Millbeeful | The Binding Of Isaac: Rebirth :: The Start (Episode #1) {Let's Play} | 74,743 | Let's Play |
| 4. | Pedguin | Afterbirth Seed: Mage Playthrough | 60,061 | Let's Play |
| 5. | Mr Samuel Streamer | Tutorial/Introduction to the Binding of Isaac (ft God Awful Run) | Binding of Isaac: Repentance #1 | 56,782 | Let's Play |
| 6. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 1 (With Chat) | 25,758 | Let's Play |
| 7. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 2 (With Chat) | 22,507 | Let's Play |
| 8. | YetiHype | Binding of Isaac: Rebirth - sheol setseed Speedrun in 9:39 - Azazel Former WR | 21,304 | Let's Play |
| 9. | Unofficial Nerdcubed Live! - Livestream Archive | NerdΒ³ Plays Isaac At 5am - Binding of Isaac Afterbirth+ - 18th September 2017 | 20,836 | Let's Play |
| 10. | TVR | The House in Fata Morgana / Chapter 3 (PS Vita Gameplay) | 20,534 | Let's Play |
| 11. | TheTurtleMelon | REPENTANCE IS HERE!! - Let's Play The Binding of Isaac Repentance - Part 1 | 18,825 | Let's Play |
| 12. | Mr Samuel Streamer | Crying My Way Through New Content | Binding of Isaac: Repentance #2 | 18,083 | Let's Play |
| 13. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Episode 1 [Beginnings] | 14,655 | Let's Play |
| 14. | Mr Samuel Streamer | New Final Boss? What ARE You? | Binding of Isaac: Repentance #3 | 14,375 | Let's Play |
| 15. | Mr Samuel Streamer | Keys, Bombs, and Hearts + Moving Channels! | Binding of Isaac: Repentance #4 | 13,857 | Let's Play |
| 16. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 3 (With Chat) | 12,197 | Let's Play |
| 17. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Episode 2 [Greed] | 9,509 | Let's Play |
| 18. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 4 (With Chat) | 9,507 | Let's Play |
| 19. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Episode 3 [Satan] | 8,879 | Let's Play |
| 20. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 7 (With Chat) | 8,448 | Let's Play |
| 21. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 6 (With Chat) | 7,972 | Let's Play |
| 22. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 10 (With Chat) | 7,376 | Let's Play |
| 23. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 9 (With Chat) | 7,292 | Let's Play |
| 24. | TheTurtleMelon | 100s OF NEW ITEMS, ROOMS AND ENEMIES! - Mega Modded The Binding of Isaac Repentance - Part 1 | 6,911 | Let's Play |
| 25. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 8 (With Chat) | 6,789 | Let's Play |
| 26. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Episode 4 [Microscopic] | 6,769 | Let's Play |
| 27. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Episode 6 [Raining Steve] | 6,648 | Let's Play |
| 28. | Millbeeful | Millbee has his first run | The Binding of Isaac: Afterbirth+ | 6,543 | Let's Play |
| 29. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 20 (With Chat) | 6,490 | Let's Play |
| 30. | Flik's Gaming Stuff | Flik Plays The Binding of Isaac Afterbirth+ | #1 | "G-Rank Theory" | 6,425 | Let's Play |
| 31. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Episode 5 [Distraction] | 6,421 | Let's Play |
| 32. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 17 (With Chat) | 6,363 | Let's Play |
| 33. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 5 (With Chat) | 6,248 | Let's Play |
| 34. | RedGamingTech | Playstation 4 Playgo Caching System & Game Installation Process Details - 500GB Enough? - Analysis | 6,232 | Let's Play |
| 35. | Charlotte & Zeke | Let's Play The Binding of Isaac TRUE CO-OP MOD EPISODE 3 | Double Brimstone!? | 6,219 | Let's Play |
| 36. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 13 (With Chat) | 6,152 | Let's Play |
| 37. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 14 (With Chat) | 6,130 | Let's Play |
| 38. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 15 (With Chat) | 6,073 | Let's Play |
| 39. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Episode 13 [Rainbows] | 5,985 | Let's Play |
| 40. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 18 (With Chat) | 5,836 | Let's Play |
| 41. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Episode 8 [Hush] | 5,829 | Let's Play |
| 42. | Millbeeful | The Binding Of Isaac: Afterbirth - Millbee Plays - Episode 25 [Lilith] | 5,797 | Let's Play |
| 43. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 19 (With Chat) | 5,756 | Let's Play |
| 44. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Episode 9 [Pretty] | 5,754 | Let's Play |
| 45. | Flik's Gaming Stuff | The Binding of Isaac: Antibirth | Part 4 | "One Punch" | 5,636 | Let's Play |
| 46. | TheTurtleMelon | BUILDING THE KNIFE - Let's Play The Binding of Isaac Repentance - Part 2 | 5,634 | Let's Play |
| 47. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Daily Challenge | 5,596 | Let's Play |
| 48. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 11 (With Chat) | 5,530 | Let's Play |
| 49. | Neo Rambler | Let's Play The Binding Of Isaac (Rebirth) Blind (PC): Part 1 | 5,450 | Let's Play |
| 50. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Episode 11 [Cat Paw Lollipop] | 5,393 | Let's Play |
| 51. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Episode 7 [Big Man] | 5,298 | Let's Play |
| 52. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 21 (With Chat) | 5,295 | Let's Play |
| 53. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Episode 10 [Dunce] | 5,187 | Let's Play |
| 54. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 22 (With Chat) | 5,137 | Let's Play |
| 55. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Episode 14 [Holy] | 4,980 | Let's Play |
| 56. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Episode 15 [Missing Hud] | 4,882 | Let's Play |
| 57. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Episode 17 [Traction] | 4,843 | Let's Play |
| 58. | Millbeeful | The Binding Of Isaac: Afterbirth - Millbee Plays - Episode 43 [Split] | 4,780 | Let's Play |
| 59. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Episode 16 [Gate] | 4,765 | Let's Play |
| 60. | Millbeeful | The Binding Of Isaac: Afterbirth - Millbee Plays - Episode 30 [Hollowed Pin] | 4,714 | Let's Play |
| 61. | Stylosa | The Binding of Isaac: Rebirth Co-op - PlayStation 4 Gameplay - Baby Ghost! | 4,696 | Let's Play |
| 62. | TheTurtleMelon | NEW ALT PATH BOSS!! - Let's Play The Binding of Isaac Repentance - Part 3 | 4,687 | Let's Play |
| 63. | Millbeeful | The Binding Of Isaac: Afterbirth - Millbee Plays - Episode 28 [Sacrifice] | 4,611 | Let's Play |
| 64. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Episode 12 [Skull Face] | 4,599 | Let's Play |
| 65. | Millbeeful | The Binding Of Isaac: Afterbirth - Millbee Plays - Episode 37 [Ring From Above] | 4,580 | Let's Play |
| 66. | Millbeeful | The Binding Of Isaac: Afterbirth - Millbee Plays - Episode 41 [Glitched] | 4,579 | Let's Play |
| 67. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 12 (With Chat) | 4,483 | Let's Play |
| 68. | Flik's Gaming Stuff | The Binding of Isaac: Antibirth | Part 6 | "Piece of the Puzzle" | 4,463 | Let's Play |
| 69. | Millbeeful | The Binding Of Isaac: Rebirth - #108 - Death's Reflection | 4,449 | Let's Play |
| 70. | 2 old 4 gaming | Binding of Isaac PSVita Physical Copy Discovered and History of Nicalis PS Vita Physical Releases | 4,427 | Let's Play |
| 71. | Millbeeful | The Binding Of Isaac: Afterbirth - Millbee Plays - Episode 31 [Blinded] | 4,381 | Let's Play |
| 72. | Millbeeful | Millbee feels greedier | The Binding of Isaac: Afterbirth+ - Episode 2 | 4,367 | Let's Play |
| 73. | Millbeeful | The Binding Of Isaac: Afterbirth - Millbee Plays - Episode 22 [Testament] | 4,362 | Let's Play |
| 74. | Millbeeful | The Binding Of Isaac: Afterbirth - Millbee Plays - Episode 39 [Fecality] | 4,353 | Let's Play |
| 75. | Millbeeful | The Binding Of Isaac: Afterbirth - Millbee Plays - Episode 26 [Samson] | 4,325 | Let's Play |
| 76. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Episode 24 [Cardiovascular] | 4,321 | Let's Play |
| 77. | Millbeeful | Millbee goes Boom | The Binding of Isaac: Afterbirth+ - Episode 3 | 4,294 | Let's Play |
| 78. | Millbeeful | The Binding Of Isaac: Afterbirth - Millbee Plays - Episode 32 [Skull Face] | 4,266 | Let's Play |
| 79. | MrAndersonLP | I BROKE THE GAME! ALL ITEMS - The Binding of Isaac: Afterbirth LIVE Let's Play [Episode 4] | 4,264 | Let's Play |
| 80. | Wilsonator | Wilsonator Plays: The Binding of Isaac - Rebirth | 4,238 | Let's Play |
| 81. | Millbeeful | The Binding Of Isaac: Afterbirth - Millbee Plays - Episode 38 [Colours] | 4,177 | Let's Play |
| 82. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Episode 19 [Depths of evil] | 4,153 | Let's Play |
| 83. | Flik's Gaming Stuff | The Binding of Isaac: Antibirth | Part 11 | "The Witness" | 4,133 | Let's Play |
| 84. | Millbeeful | Millbee eats the electric pizza slice | The Binding of Isaac: Afterbirth+ | 4,063 | Let's Play |
| 85. | Flik's Gaming Stuff | The Binding of Isaac: Antibirth | Part 7 | "Darkness Unchanged" | 4,058 | Let's Play |
| 86. | Millbeeful | The Binding Of Isaac: Afterbirth - Let's Play - Episode 18 [Formations] | 4,051 | Let's Play |
| 87. | Millbeeful | The Binding Of Isaac: Afterbirth - Millbee Plays - Episode 40 [Aqua] | 4,048 | Let's Play |
| 88. | Mikehyphenplays | Unlocking Azazel: The Binding of Issac #14 | 4,044 | Let's Play |
| 89. | TheTurtleMelon | What is The Binding of Isaac Nuzlocke? (Introduction and First Run) | 4,036 | Let's Play |
| 90. | Forsen Plays | Forsen Plays The Binding of Isaac: Repentance - Part 16 | 4,013 | Let's Play |
| 91. | Millbeeful | Millbee explains Shrinks | The Binding of Isaac: Afterbirth+ - Episode 6 | 3,951 | Let's Play |
| 92. | MrAndersonLP | D20 BREAKING GREED MODE - The Binding of Isaac: Afterbirth LIVE Let's Play [Episode 16] | 3,950 | Let's Play |
| 93. | Millbeeful | The Binding Of Isaac: Afterbirth - Millbee Plays - Episode 36 [Paperback] | 3,947 | Let's Play |
| 94. | Millbeeful | The Binding Of Isaac: Afterbirth - Millbee Plays - Episode 42 [Rusty] | 3,944 | Let's Play |
| 95. | Flik's Gaming Stuff | Flik Plays The Binding of Isaac Afterbirth+ | #2 | "Sccyytttthheess" | 3,942 | Let's Play |
| 96. | Millbeeful | The Binding Of Isaac: Rebirth - #109 - Coal Watch | 3,923 | Let's Play |
| 97. | TheTurtleMelon | BETHANY SOO FUN! - Let's Play The Binding of Isaac Repentance - Part 5 | 3,909 | Let's Play |
| 98. | Millbeeful | The Binding Of Isaac: Afterbirth - Millbee Plays - Episode 44 [Worm Master] | 3,900 | Let's Play |
| 99. | Flik's Gaming Stuff | The Binding of Isaac: Antibirth | Part 12 | "Jacob & Esau" | 3,849 | Let's Play |
| 100. | Millbeeful | The Binding Of Isaac: Afterbirth - Millbee Plays - Episode 33 [Bleeding Cellar] | 3,842 | Let's Play |
