3D Structure of Rabbit ACE2 and Its Comparison with Human ACE2: Insights into Structural Biology
0Rabbit Angiotensin converting Enzyme2: 3D Structural Reconstruction and Comparison with its Human Analog
Layman Abstract : This research focuses on a protein called ACE2, which plays an important role in controlling blood pressure and is also known for being the entry point the coronavirus uses to infect human cells. Scientists wanted to understand how this protein works in rabbits, since rabbits are often used in medical research. To do this, they compared the rabbit version of the ACE2 protein with the human version. The two proteins are very similar, sharing 85% of the same building blocks (amino acids). Using computer modeling, researchers created a 3D structure of the rabbit protein based on the human one. They found that the overall shapes of the two proteins are almost the same, especially in the parts that are structured like coils (called alphahelices). Although there were a few small differences in some unstructured regions, the rabbit protein was actually a bit more stable. Because of this strong similarity in both shape and behavior, the study supports using rabbits as a good model for studying how the coronavirus infects cells and how ACE2 helps regulate blood pressure in ways that are relevant to humans.
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#ACE2 #rACE2 #hACE2 #ProteinStructure #3DProteinModeling #MolecularBiology #StructuralBiology #ProteinAlignment #Bioinformatics #ThermodynamicStability #COVID19Research #CoronavirusReceptor #SProtein #ViralEntryMechanism #ZoonoticDiseases #AnimalModelResearch #RabbitModel #ComparativeGenomics #TranslationalResearch #BiomedicalResearch #PreclinicalModels #BloodPressureRegulation #ReninAngiotensinSystem #CardiovascularResearch
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