biosights: September 4 2017 - A new aspect on ASC specks

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United States Rockefeller University Press
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Published on ● Video Link: https://www.youtube.com/watch?v=R4AOA4oxBAY


Duration: 7:58
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Invading pathogens or other toxic agents can trigger the assembly of the inflammasome adaptor ASC into large, intracellular specks that activate caspase-1 to initiate a proinflammatory cell death called pyroptosis. Kuri et al. follow the dynamics of ASC speck formation in live zebrafish, revealing their lethal effects on epidermal keratinocytes and their subsequent engulfment and degradation by macrophages. This biosights episode presents the paper by Kuri et al. from the September 4th, 2017, issue of The Journal of Cell Biology and includes an interview with two of the paper’s authors, Paola Kuri and Maria Leptin (EMBL). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB (http://jcb.rupress.org/content/216/9/2891) for details on the funding provided to support this original research.



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Tags:
NLR
Caspa
epidermal extrusion
phagocytosis
caspase
zebrafish
inflammasome
ASC
pyroptosis
CRISPR/Cas9
innate immunity
cell biology