biosights: February 5 2018 - Cytotoxic T cells use Flower power

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Rockefeller University Press

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Published on February 5, 2018 2:18:27 PM ● Video Link: https://www.youtube.com/watch?v=31nqEQ-x02k

Duration: 7:20

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In order to efficiently kill multiple target cells, cytotoxic T lymphocytes must endocytose and recycle cytotoxic granule membrane components from the immunological synapse. Chang et al. reveal that a protein called Flower facilitates granule endocytosis in a calcium-dependent manner. This biosights episode presents the paper by Chang et al. from the February 5th, 2018, issue of the Journal of Cell Biology and includes an interview with one of the paper’s senior authors, Jens Rettig (Saarland University, Germany). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB (https://doi.org/10.1083/jcb.201706053) for details on the funding provided to support this original research.