biosights: December 4 2017 - Adult neuroblasts DOCK into position

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Published on ● Video Link: https://www.youtube.com/watch?v=0EOCm3LycRI


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In the post-natal/adult brain, interneuron precursors, or neuroblasts, migrate along the rostral migratory stream by undergoing cycles of leading process extension followed by somal translocation. Nakamuta et al. reveal that the Rac/Cdc42 guanine nucleotide exchange factor DOCK7 coordinates this migratory cycle by regulating both Rac-dependent leading process extension and p116Rip-dependent actin assembly at the cell rear. This biosights episode presents the paper by Nakamuta et al. from the December 4th, 2017, issue of The Journal of Cell Biology and includes an interview with the paper’s senior author, Linda Van Aelst (Cold Spring Harbor Laboratory, NY). Produced by Caitlin Sedwick and Ben Short. See the associated paper (https://doi.org/10.1083/jcb.201704157) in JCB for details on the funding provided to support this original research.



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Tags:
DOCK180 family
ventricular-subventricular zone neuroblasts
tangential migration
leading process extension
nucleokinesis
cytoskeletal remodeling
somal translocation
neuronal migration
neurogenesis
DOCK7
actin
microtubules
rostral migratory stream
neurobiology
cell biology