The brass wand really wrecks Dredmor. The "dazed" effect it inflicts is considered to be a buff rather than a debuff; the practical effect of being a "buff" is that monsters don't get a chance to resist it. Even if they are the final boss.
If I didn't find a brass wand, the backup plan was to trick Dredmor into stepping on an antimagic trap that I picked up from level 1.
00:00 hello intertubers
00:57 back to real world
03:30 Level 9
07:57 A sad realization
08:25 Dungeon level 10!
11:57 Dredmor can't open doors
13:55 Bolts of mass destruction can't open doors either
14:12 PARANORMAL INVESTIGATOR
14:50 Boss fight begins
16:53 ...and he's dead.
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