| 401. | They Added Playable Donation Machine To The Game! It Was A Mistake. | 174 | |
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| 402. | This New Spoon Bender Brings Homing To The Next Level! | 229 | |
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| 403. | This New Keeper Challenge Is Extremely Hard! | 161 | | The Binding of Isaac: Rebirth
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| 404. | This New Item Gave Me Infinite Tears! | 143 | |
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| 405. | This New Item Turns Isaac Into Scariest Boss! | 115 | | The Binding of Isaac: Rebirth
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| 406. | This New Golden Mushroom Gives INSANE Stats! | 178 | | The Binding of Isaac: Rebirth
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| 407. | This New Modded Character Creates Insane Items! | 91 | |
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| 408. | This New Transformation Is Too Horrifying! Epiphany Challenge #10 | 130 | |
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| 409. | This New Golden Keeper Is Extremely Greedy! | 124 | |
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| 410. | This New Isaac Transformation Is Literally CURSED! | 74 | | The Binding of Isaac: Rebirth
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| 411. | Tainted Lost Double Brimstone Run | 90 | | Brimstone
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| 412. | I Finally Achieved Giga Luck In Isaac! | 97 | | The Binding of Isaac: Rebirth
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| 413. | This New Satan's Contract Gave Me Unlimited Power! | 123 | | The Binding of Isaac: Rebirth
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| 414. | This New Item Gave Me Every Quality 4 Possible! | 80 | |
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| 415. | This New Quality 4 Gives You The Best Items In The Game! | 141 | |
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| 416. | This New Dice Literally Broke My Game! | 70 | | The Binding of Isaac
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| 417. | This New Item Gave Me Insane Damage! | 133 | | The Binding of Isaac: Rebirth
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| 418. | The Painful Truth About Tarnished Lost... | 149 | |
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| 419. | Isaac, But Every Enemy Is Also Isaac | 172 | | The Binding of Isaac: Rebirth
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| 420. | I Broke World Record And Became The Richest Isaac Player! | 113 | | The Binding of Isaac: Rebirth
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| 421. | I Faced The Hardest Secret Boss In Isaac History! | 133 | | The Binding of Isaac: Rebirth
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| 422. | This New Dice Completely Broke My Game! | 113 | |
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| 423. | This New Item Gives You Super Homing Tears! | 180 | |
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| 424. | This New Playable Dead Isaac Is Insane! | 198 | | The Binding of Isaac: Rebirth
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| 425. | These New Sacrifice Rooms Are Completely Broken! | 94 | |
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| 426. | Isaac Online Is Finally Out! Getting New Achievements & More! | 92 | | The Binding of Isaac: Rebirth
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| 427. | They Turned Crane Game Into A Character! It's BROKEN! | 183 | |
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| 428. | This Trinket Adds Unique Effects For Every Character! | 113 | |
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| 429. | These New Isaac Unlocks Are INSANE! | 158 | | The Binding of Isaac: Rebirth
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| 430. | This New Spider Character Is Too Toxic! | 105 | |
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| 431. | New Way Of Unlocking Tarnished Judas Is Too Scary! | 104 | |
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| 432. | Money=Power Got A Huge Upgrade! It Gives Insane Damage! | 84 | |
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| 433. | Tainted Sin Is Extremely Broken! (0.01% Gamebreak) | 107 | | The Binding of Isaac: Rebirth
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| 434. | THIS Will Give You Every Angel Item In The Game! | 122 | |
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| 435. | Isaac Run, But Every Item Is A Golden Horse Pill... | 217 | | The Binding of Isaac: Rebirth
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| 436. | All Isaac Transformations In One Run! | 115 | | The Binding of Isaac: Rebirth
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| 437. | This Reworked Golden Razor Gives Insane Damage! | 95 | |
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| 438. | This New Item Gave Me The Best Familiars! | 74 | |
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| 439. | This New Item Is Better Than Homing! Isaac With Aimbot! | 117 | | The Binding of Isaac: Rebirth
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| 440. | I Got The Best Familiar Upgrade EVER! | 142 | | The Binding of Isaac: Rebirth
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| 441. | The Luckiest Isaac Run I've Ever Had! | 69 | | The Binding of Isaac: Rebirth
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| 442. | Isaac Run, But Every Room I Get A New Character! | 79 | | The Binding of Isaac: Rebirth
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| 443. | This New Character Has Crazy Abilities! Sin Gameplay! | 142 | | SiN
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| 444. | This New Character Has Electric Brimstone! Zoe Gameplay! | 149 | | Brimstone
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| 445. | These Alternative Horsemen Bosses Are Extremely Hard! | 109 | |
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| 446. | Isaac, But He's Addicted To 'Sugar'... | 122 | | The Binding of Isaac: Rebirth
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| 447. | This New Character Has Craziest Items! Researcher Gameplay! | 201 | |
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| 448. | Early Version Of Tainted Eden Is Extremely Glitched... | 124 | |
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| 449. | They Added A New Beggar To The Game! He's Hilarious! | 168 | |
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| 450. | The Craziest Character I've Ever Played! Tainted Zoe Gameplay! | 126 | |
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| 451. | This New Character Gets Stats For Every Kill! | 124 | |
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| 452. | This New Character Can't Take ANY Items! | 131 | |
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| 453. | This New Item Changes Your Tears With Giant Brimstone! | 111 | | The Binding of Isaac: Rebirth
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| 454. | They Made Delirious Isaac. He's literally BROKEN! | 149 | | The Binding of Isaac: Rebirth
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| 455. | Alcoholic Catgirl Is Ridiculously Drunk! | 140 | |
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| 456. | These New Akeldama Synergies Are Absolutely BROKEN! | 123 | |
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| 457. | This New Item Turns Everything Into GOLD! | 125 | | The Binding of Isaac: Rebirth
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| 458. | Playing New Pure Isaac Is Extremely Fun! | 194 | | The Binding of Isaac: Rebirth
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| 459. | I Tried The Darkest Challenge In Isaac! | 74 | | The Binding of Isaac: Rebirth
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| 460. | These New Alternative Final Bosses Are Crazy Hard! | 125 | | The Binding of Isaac: Rebirth
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| 461. | This New Item Turns You Into True Werewolf! | 56 | |
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| 462. | They Added New Technology Item! It's Extremely Powerful! | 80 | |
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| 463. | This New Technology Item Has Insane Synergies! | 128 | |
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| 464. | Jacob And Esau Run, But Only One Takes All The Items! | 60 | |
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| 465. | This New Item Literally Destroyed My Shops! | 84 | |
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| 466. | This New Character Can Create Isaac Army! | 118 | | The Binding of Isaac: Rebirth
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| 467. | This New Item Has The Craziest Synergies! | 109 | |
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| 468. | Pure Maggy Is Extremely Cute! | 209 | |
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| 469. | I Tried Best Multishot Item In The Game! It's CRAZY! | 86 | |
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| 470. | Tainted Delirium Is Insanely Hard... | 267 | |
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| 471. | This New Character Can Spawn Army Of Zombies! | 164 | | The Binding of Isaac: Rebirth
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| 472. | I Finally Unlocked Tarnished ???/Blue Baby! It's AMAZING! | 105 | |
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| 473. | This New Rock Bottom Almost Destroyed My PC! | 308 | | The Binding of Isaac: Rebirth
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| 474. | This New Character Gets The WORST Items Only! Tainted Bandit Gameplay! | 114 | | Bandits
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| 475. | This New Cyborg Transformation Is Literally BROKEN! | 126 | | The Binding of Isaac: Rebirth
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| 476. | This New Dice Hits The Luckiest Rerolls Ever! | 79 | |
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| 477. | I Finally Got ALL Achievements In Isaac And It's INSANE! | 87 | | The Binding of Isaac: Rebirth
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| 478. | This New Technology Gives You The Biggest Laser Shot EVER! | 190 | |
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| 479. | This New Cursed Room Gave Me The Best Items! | 115 | |
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| 480. | They Turned The Entire Solar System Into A Character! It's INSANE! | 215 | |
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| 481. | New Upgraded Mutant Spider Is Extremely Powerful! | 157 | |
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| 482. | This New Character Has The Most Powerful Abilities! | 82 | |
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| 483. | This New Quality 4 Gives You Every Item Possible! | 127 | | The Binding of Isaac: Rebirth
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| 484. | This New Tainted Character Is Extremely Hard... | 164 | |
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| 485. | This New Item Gave Me The Most Chaotic Tears Ever! | 122 | |
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| 486. | This New Item Almost Crashed My Game! | 158 | |
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| 487. | This New Item Literally Broke My Game! | 104 | |
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| 488. | The Secret Character From Godmode Achieved! The Sign Gameplay! | 191 | |
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| 489. | This New Quality 4 Item Gives INSANE Damage! | 139 | |
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| 490. | I Finally Played As Pure Judas! He's Completely BROKEN! | 293 | |
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| 491. | Can I Survive With Isaac's Heart As Tainted Lost? | 80 | | The Binding of Isaac: Rebirth
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| 492. | Playable Fortune Telling Machine Is Hilarious! | 154 | |
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| 493. | This Devil Deal Literally Broke My Game! | 71 | |
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| 494. | I Found The Easiest Way To Get Into All Rooms In Isaac! | 57 | | The Binding of Isaac: Rebirth
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| 495. | New Reworked Tarnished Judas Is INSANE! | 160 | |
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| 496. | This New Lilith Has Insane LUCK! | 119 | |
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| 497. | This New Crooked Penny Is Too Risky... | 97 | |
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| 498. | Isaac, But Every Time I Die I Get More Stats! | 62 | | The Binding of Isaac: Rebirth
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| 499. | This New Item Turns Isaac Into Scariest Demonic Creature! | 160 | | The Binding of Isaac: Rebirth
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| 500. | This New Secret Miniboss Is Too Horrifying! | 175 | |
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