| 201. | This New Cyborg Transformation Is Literally BROKEN! | 2,588 | | The Binding of Isaac: Rebirth
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| 202. | After A Year Of Asking... I FINALLY FOUND IT! | 2,585 | | The Binding of Isaac: Rebirth
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| 203. | This Trinket Adds Unique Effects For Every Character! | 2,584 | |
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| 204. | This New Item Almost Broke My Game! | 2,583 | |
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| 205. | This New Planetarium Transformation In Isaac Is AMAZING! | 2,573 | | The Binding of Isaac: Rebirth
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| 206. | Isaac Will Never Be The Same Again... | 2,573 | | The Binding of Isaac: Rebirth
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| 207. | Isaac Online Is Finally Out! Getting New Achievements & More! | 2,561 | | The Binding of Isaac: Rebirth
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| 208. | I Finally Unlocked Tarnished Keeper! The Luckiest 120 Fire Rate Greedier! | 2,555 | | The Binding of Isaac: Rebirth
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| 209. | I Found New Broken Godhead! It's INSANE! | 2,544 | |
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| 210. | This New Crooked Penny Is Too Risky... | 2,542 | |
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| 211. | This New Pepper Item Is Absolutely BROKEN! | 2,541 | | The Binding of Isaac: Rebirth
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| 212. | Is It Possible To Win Isaac Run Without ANY Kills? | 2,537 | | The Binding of Isaac: Rebirth
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| 213. | This New Character Can Create Familiars! Tainted Siren Gameplay! | 2,531 | | The Binding of Isaac: Rebirth
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| 214. | This New Tainted Character Can Evolve! | 2,522 | | The Binding of Isaac: Rebirth
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| 215. | This New Upgraded Sacred Orb Is INSANE! | 2,512 | |
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| 216. | I Finally Got ALL Achievements In Isaac And It's INSANE! | 2,506 | | The Binding of Isaac: Rebirth
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| 217. | I Played The Hardest Isaac Challenge Ever... | 2,506 | | The Binding of Isaac: Rebirth
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| 218. | This New Characters Controls Flies! The Hollow Gameplay! | 2,505 | | The Binding of Isaac: Rebirth
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| 219. | The Most Powerful Character Ever Made! Godhead Gameplay! | 2,486 | | The Binding of Isaac: Rebirth
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| 220. | With This Shovel You Can Find Secret Isaac Items! | 2,474 | | The Binding of Isaac: Rebirth
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| 221. | This New Item Gave Me The Most Chaotic Tears Ever! | 2,459 | |
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| 222. | I Got The Best Items For Tarnished Judas! 11 Shadows Madness! | 2,457 | | The Binding of Isaac: Rebirth
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| 223. | Early Version Of Tainted Eden Is Extremely Glitched... | 2,449 | |
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| 224. | Champion Cain Gets Quality 4 Items For Free! | 2,442 | | The Binding of Isaac: Rebirth
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| 225. | They Added A New Spider Character! It's Extremely Cute! | 2,440 | | The Binding of Isaac: Rebirth
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| 226. | The Most Unexpected Gamebreak In Isaac History... | 2,437 | | The Binding of Isaac: Rebirth
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| 227. | They Added A New Upgradable Meat Boy! It's Extremely Cute! | 2,429 | | The Binding of Isaac: Rebirth
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| 228. | Isaac, But He's Addicted To 'Sugar'... | 2,427 | | The Binding of Isaac: Rebirth
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| 229. | Playable Santa Is Insanely Overpowered! | 2,424 | |
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| 230. | I Finally Got The Best Item For Tainted Samael! | 2,415 | | The Binding of Isaac: Rebirth
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| 231. | Fall From Grace Got Updated! Grotto Floor Release! | 2,413 | | The Binding of Isaac: Rebirth
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| 232. | This New Character Has The Craziest Synergies! | 2,412 | | The Binding of Isaac: Rebirth
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| 233. | How I Got 25 Damage Multiplier? Tainted Isaac Godlike Run! | 2,403 | | The Binding of Isaac: Rebirth
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| 234. | The Cutest Demon Character Ever Made! Baphomet Gameplay! | 2,402 | | The Binding of Isaac: Rebirth
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| 235. | I Unlocked The Craziest Tainted Character In The Game... | 2,400 | | The Binding of Isaac: Rebirth
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| 236. | These Tainted Planetarium Items Are Completely CURSED! | 2,380 | | The Binding of Isaac: Rebirth
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| 237. | Champion Tainted Jacob Is Extremely Hard... | 2,379 | | The Binding of Isaac: Rebirth
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| 238. | The Most Broken Character Ever Made! Bandit Gameplay! | 2,365 | | Bandits
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| 239. | This New Item Has The Craziest Synergies! | 2,365 | |
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| 240. | I Broke World Record And Became The Richest Isaac Player! | 2,363 | | The Binding of Isaac: Rebirth
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| 241. | Tainted Sin Is Extremely Broken! (0.01% Gamebreak) | 2,362 | | The Binding of Isaac: Rebirth
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| 242. | This New Alabaster Box Gives You ALL Angel Items! | 2,351 | |
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| 243. | New Character In Repentance??? Chaotic Tears Run! | 2,333 | | The Binding of Isaac: Rebirth
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| 244. | This New Item Literally Broke My Game! | 2,326 | |
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| 245. | These New Akeldama Synergies Are Absolutely BROKEN! | 2,325 | |
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| 246. | I Finally Unlocked Tarnished ???/Blue Baby! It's AMAZING! | 2,320 | |
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| 247. | This New Candle Transformation Is Absolutely Incredible! | 2,316 | | The Binding of Isaac: Rebirth
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| 248. | These New Sacrifice Rooms Are Completely Broken! | 2,303 | |
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| 249. | What Happens If Azazel Gets Birthright, Double Brimstone And Tech X? | 2,301 | | The Binding of Isaac: Rebirth
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| 250. | I Finally Unlocked Tarnished Cain! (The New Way) | 2,296 | | The Binding of Isaac: Rebirth
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| 251. | They Made A Playable Miniboss And It's Amazing! | 2,292 | | The Binding of Isaac: Rebirth
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| 252. | Angel Items Everyone Wants To See! Ultra Lucky Tainted Lost! | 2,281 | | The Binding of Isaac: Rebirth
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| 253. | This New Item Literally Destroyed My Shops! | 2,280 | |
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| 254. | This New Character Almost Broke My Game! Reap And Tear Gameplay! | 2,274 | | The Binding of Isaac: Rebirth
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| 255. | This New Demon Character Is INSANE! David Gameplay! | 2,271 | | The Binding of Isaac: Rebirth
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| 256. | This New Future Floor Is INSANE! | 2,261 | | The Binding of Isaac: Rebirth
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| 257. | This New Item Instantly Breaks The Game! | 2,259 | | The Binding of Isaac: Rebirth
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| 258. | This New Character Has Cursed Items! Bael Gameplay! | 2,248 | | The Binding of Isaac: Rebirth
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| 259. | They Added New Portals To Isaac. It's Amazing! | 2,242 | | The Binding of Isaac: Rebirth
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| 260. | This Reworked Golden Razor Gives Insane Damage! | 2,238 | |
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| 261. | This New Character Gets The WORST Items Only! Tainted Bandit Gameplay! | 2,230 | | Bandits
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| 262. | This New Character Has The Craziest Tears! | 2,216 | | The Binding of Isaac: Rebirth
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| 263. | What Happens If Replace Every Item With Mystery Gift? Craziest Judas Run? | 2,216 | | The Binding of Isaac: Rebirth
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| 264. | This New Technology Item Almost Crashed My Game! | 2,204 | |
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| 265. | This New Planetarium Boss Is IMPOSSIBLE To Defeat! | 2,191 | | The Binding of Isaac: Rebirth
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| 266. | This New Character Has 11 Broken Hearts?! Tainted Leah Gameplay! | 2,188 | | The Binding of Isaac: Rebirth
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| 267. | This New Upgradable Item Is Literally INSANE! | 2,184 | | The Binding of Isaac: Rebirth
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| 268. | These New Dice Give Every Devil Items Possible! | 2,155 | | The Binding of Isaac: Rebirth
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| 269. | These Alternative Horsemen Bosses Are Extremely Hard! | 2,153 | |
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| 270. | How I Got 120 Fire Rate! Forgotten 3 Hour Run! | 2,147 | | The Binding of Isaac: Rebirth
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| 271. | This New Character Can Create Isaac Army! | 2,143 | | The Binding of Isaac: Rebirth
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| 272. | They Made Playable Siren Boss! It's INSANE! | 2,142 | | The Binding of Isaac: Rebirth
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| 273. | Tainted David's Abilities Are Too Broken! | 2,142 | | The Binding of Isaac: Rebirth
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| 274. | I Finally Got My Luckiest Tainted Keeper Run Ever! | 2,098 | | The Binding of Isaac: Rebirth
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| 275. | I Got The Biggest Spirit Sword In The World! | 2,097 | | The Binding of Isaac: Rebirth
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| 276. | This New Silver Crown Gave Me Infinite Stats! | 2,086 | | The Binding of Isaac: Rebirth
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| 277. | This New Item Gives You Infinite Stats! | 2,082 | | The Binding of Isaac: Rebirth
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| 278. | I Got The Cheapest Gamebreak In Isaac History! | 2,081 | | The Binding of Isaac: Rebirth
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| 279. | I Got The Fastest Brimstone Ever! Luckiest Tarnished Eden Run! | 2,079 | | The Binding of Isaac: Rebirth
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| 280. | The Craziest Character Ever Made! Tarnished Blue Baby Gameplay! | 2,078 | |
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| 281. | I Found The Best Familiar In The Game! It's CRAZY! | 2,054 | | The Binding of Isaac: Rebirth
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| 282. | I Got Every Damage Multiplier Item In Isaac! | 2,040 | | The Binding of Isaac: Rebirth
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| 283. | I Finally Tried Spinup Dice! It's Even More Broken! | 2,028 | |
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| 284. | I Completely Broke This New Isaac Challenge! Epiphany Challenge #5 | 2,027 | | The Binding of Isaac: Rebirth
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| 285. | This New Guppy Transformation Changes Everything! | 2,016 | | The Binding of Isaac: Rebirth
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| 286. | They Made Devil Version Of Sacred Heart! It's INSANE! | 2,004 | | The Binding of Isaac: Rebirth
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| 287. | This New Item Turns Isaac Into A Cthulhu! | 1,997 | | The Binding of Isaac: Rebirth
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| 288. | You Need Only 2 Items To Win! Cain's Risky Run! | 1,991 | | The Binding of Isaac: Rebirth
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| 289. | These New Eternal Bosses Are Extremely Hard! | 1,983 | | The Binding of Isaac: Rebirth
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| 290. | This New Book Gives You Literally Everything! | 1,974 | | The Binding of Isaac: Rebirth
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| 291. | New Forgotten Is Absolutely Amazing! | 1,968 | | The Binding of Isaac: Rebirth
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| 292. | I Finally Got The Craziest Tainted Samael Synergy! | 1,962 | | The Binding of Isaac: Rebirth
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| 293. | How I Shot Giant Rockets As Tainted Lost! | 1,943 | |
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| 294. | These New Angel Bosses Are Insanely HARD! | 1,939 | | The Binding of Isaac: Rebirth
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| 295. | Playable Rainmaker Has The Most Satisfying Synergies! | 1,938 | | The Binding of Isaac: Rebirth
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| 296. | This New Book Gives You Infinite Damage! | 1,924 | | The Binding of Isaac: Rebirth
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| 297. | I Tried Best Multishot Item In The Game! It's CRAZY! | 1,923 | |
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| 298. | This New Dice Hits The Luckiest Rerolls Ever! | 1,919 | |
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| 299. | This New Upgradable Familiar Is Amazing! Retribution Challenge #4 | 1,919 | | The Binding of Isaac: Rebirth
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| 300. | This New Character Dies When The Time Runs Out! Chronos Gameplay! | 1,916 | | The Binding of Isaac: Rebirth
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