| 301. | This New Void Item Is Literally BROKEN! | 1,911 | | The Binding of Isaac: Rebirth
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| 302. | I Finally Achieved Giga Luck In Isaac! | 1,910 | | The Binding of Isaac: Rebirth
|
| 303. | This New Character Is LITERALLY Immortal! Chamuel Gameplay! | 1,903 | | The Binding of Isaac: Rebirth
|
| 304. | New Maggy Is Extremely Cute! | 1,877 | | The Binding of Isaac: Rebirth
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| 305. | This New Quality 4 Item Gives You Insane Tears! | 1,875 | | The Binding of Isaac: Rebirth
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| 306. | This New Spider Character Is Too Toxic! | 1,852 | |
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| 307. | Rock Bottom Start Using New Blighted Dice! Luckiest Tarnished Isaac Run! | 1,850 | | The Binding of Isaac: Rebirth
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| 308. | I Finally Found The Perfect Gambling Character! | 1,837 | |
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| 309. | This New Character Hits The CRAZIEST Rerolls! | 1,833 | |
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| 310. | This New Item Gave Me Every Quality 4 Possible! | 1,832 | |
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| 311. | They Added New Technology Item! It's Extremely Powerful! | 1,817 | |
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| 312. | I Got The Most Powerful Bag Synergy Ever! | 1,815 | | The Binding of Isaac: Rebirth
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| 313. | This New Character Has The Craziest Synergies! | 1,813 | |
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| 314. | I Think I Got The Rarest Drop In Isaac... | 1,798 | | The Binding of Isaac: Rebirth
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| 315. | This Synergy Almost Destroyed My PC! The Most Satisfying Lost Run! | 1,778 | | The Binding of Isaac: Rebirth
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| 316. | This Mod Adds New Planetariums With Bosses! | 1,777 | | The Binding of Isaac: Rebirth
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| 317. | This Brimstone Synergy Will One Shot Every Boss! Insane Tarnished Maggy Gamebreak! | 1,775 | | The Binding of Isaac: Rebirth
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| 318. | This New Modded Character Creates Insane Items! | 1,735 | |
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| 319. | Tainted Lost Gamebreak.exe | 1,735 | | The Binding of Isaac: Rebirth
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| 320. | Tainted Lost Double Brimstone Run | 1,734 | | Brimstone
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| 321. | These New Greedier Bosses Are Absolutely Incredible! | 1,730 | |
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| 322. | This New Item Gives You Infinite Stats! | 1,724 | | The Binding of Isaac: Rebirth
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| 323. | This New Character Has The Most Powerful Abilities! | 1,723 | |
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| 324. | This New Angel Quality 4 Item Is INSANE! | 1,718 | | The Binding of Isaac: Rebirth
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| 325. | They Turned Steven Boss Into A Character! | 1,715 | | The Binding of Isaac: Rebirth
|
| 326. | This Run Was Rigged From The Start! 10X Eden's Blessing Madness! | 1,700 | | The Binding of Isaac: Rebirth
|
| 327. | This New Magic Cube Gives The Best Items Possible! | 1,697 | | The Binding of Isaac: Rebirth
|
| 328. | Can I Survive With Isaac's Heart As Tainted Lost? | 1,690 | | The Binding of Isaac: Rebirth
|
| 329. | I Created My Own Immortal Mini Isaac Army! | 1,668 | | The Binding of Isaac: Rebirth
|
| 330. | This New Character Turns Enemies Into Stats! Peter Gameplay! | 1,659 | | The Binding of Isaac: Rebirth
|
| 331. | Champion Lost Is Extremely Hard... | 1,657 | | The Binding of Isaac: Rebirth
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| 332. | The Luckiest Isaac Run I've Ever Had! | 1,644 | | The Binding of Isaac: Rebirth
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| 333. | I Played The Most Unpleasant Isaac Challenge Ever... | 1,639 | | The Binding of Isaac: Rebirth
|
| 334. | I Did It Again! Double Death Certificate First Floor! | 1,638 | | The Binding of Isaac: Rebirth
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| 335. | This New Isaac Transformation Is Literally CURSED! | 1,627 | | The Binding of Isaac: Rebirth
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| 336. | The New Character, That Protects His Own Heart! Tainted Chamuel Gameplay! | 1,613 | | The Binding of Isaac: Rebirth
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| 337. | This New Revelations Character Gets The Best Angel Items! | 1,612 | | The Binding of Isaac: Rebirth
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| 338. | This New D6 Gave Me Every Angel Item Possible! | 1,612 | | The Binding of Isaac: Rebirth
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| 339. | Isaac Run, But Every Room I Get A New Character! | 1,601 | | The Binding of Isaac: Rebirth
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| 340. | This New Tainted Soy Milk Just Broke My Brimstone! | 1,595 | | The Binding of Isaac: Rebirth
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| 341. | This New Character Has CRAZY Synergies! Sheriff Gameplay! | 1,579 | | Sheriff
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| 342. | One Secret Room Reroll To Break The Run! All Tarnished Isaac Unlocks! | 1,565 | | The Binding of Isaac: Rebirth
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| 343. | I Played The Hardest Isaac Challenge Ever Created! | 1,558 | | The Binding of Isaac: Rebirth
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| 344. | This Challenge Has 13 New Bosses! Boss Butch Mod! | 1,548 | | The Binding of Isaac: Rebirth
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| 345. | I Finally Unlocked Secret Samael Ending In Isaac! | 1,543 | | The Binding of Isaac: Rebirth
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| 346. | Money=Power Got A Huge Upgrade! It Gives Insane Damage! | 1,530 | |
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| 347. | They Turned Guppy Into A Playable Character! | 1,525 | | The Binding of Isaac: Rebirth
|
| 348. | This Reworked First Page Is Insane! Playing As 4 Characters At Once! | 1,514 | | The Binding of Isaac: Rebirth
|
| 349. | This New Rune Gives Craziest Stats Ever! | 1,513 | | The Binding of Isaac: Rebirth
|
| 350. | This New Dice Literally Broke My Game! | 1,506 | | The Binding of Isaac
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| 351. | Angel Or Devil? The Balance of Tainted Azazel! | 1,505 | | The Binding of Isaac: Rebirth
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| 352. | I Found The Most Broken Room In Isaac History! | 1,504 | | The Binding of Isaac: Rebirth
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| 353. | Fiend Folio Damage Multipliers Are Actually Better? Insane 200 IQ Rerolls! | 1,494 | | The Binding of Isaac: Rebirth
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| 354. | This New Item Makes You Literally Immortal! | 1,479 | | The Binding of Isaac: Rebirth
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| 355. | I Played The Weirdest Challenge In Isaac... | 1,476 | | The Binding of Isaac: Rebirth
|
| 356. | Can Tarnished Cain Win Without His Bag?! Epiphany Challenge #3 | 1,474 | | The Binding of Isaac: Rebirth
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| 357. | This New Challenge Turned Me Into A God! Epiphany Challenge #8 | 1,474 | | The Binding of Isaac: Rebirth
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| 358. | The Biggest Damage Multiplier So Far! The Lost Deals Real Damage! | 1,470 | | The Binding of Isaac: Rebirth
|
| 359. | I Finally Found The BEST Item In The Entire Game! | 1,468 | | The Binding of Isaac: Rebirth
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| 360. | This Devil Deal Literally Broke My Game! | 1,468 | |
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| 361. | No Way I Got All Of These! The Luckiest Tainted Lost Run! | 1,457 | | The Binding of Isaac: Rebirth
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| 362. | I Tried The Most Epic Lazarus Challenge! | 1,442 | | The Binding of Isaac: Rebirth
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| 363. | These New Revelations Minibosses Are Amazing! | 1,433 | | The Binding of Isaac: Rebirth
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| 364. | Tainted Eden Run, But It's 100 Times More Random! | 1,433 | | The Binding of Isaac: Rebirth
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| 365. | I Finally Found New D6! It's Too Evil... | 1,419 | |
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| 366. | This New Champion Isaac Is Completely BROKEN! | 1,410 | | The Binding of Isaac: Rebirth
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| 367. | I Tried The Darkest Challenge In Isaac! | 1,404 | | The Binding of Isaac: Rebirth
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| 368. | I'll Never Get This Lucky Again... Retribution Challenge #11 | 1,394 | | The Binding of Isaac: Rebirth
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| 369. | What Happens If 11 Tarnished Judases Fight Ultra Greed?! | 1,388 | | The Binding of Isaac: Rebirth
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| 370. | You Can Never Have Too Many Q4 Items! Perfect Tainted Lost Start! | 1,382 | | The Binding of Isaac: Rebirth
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| 371. | I Got All Tech X Synergies In One Run! | 1,367 | | The Binding of Isaac: Rebirth
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| 372. | This New Character Is Too Overpowered! Samael Gameplay! | 1,332 | | The Binding of Isaac: Rebirth
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| 373. | The Most Broken Character Ever Made! Tainted Samael Gameplay! | 1,331 | | The Binding of Isaac: Rebirth
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| 374. | This New Character Is A Guru Of Gambling! Zach Gameplay! | 1,326 | | The Binding of Isaac: Rebirth
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| 375. | You Won't Believe This First Floor! The Luckiest Forgotten Run Ever! | 1,311 | | The Binding of Isaac: Rebirth
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| 376. | HOW MUCH G FUEL CAN I GET? Isaac's Crazy G Fuel Challenge! | 1,308 | | The Binding of Isaac: Rebirth
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| 377. | Tainted Mastema Gets Broken Hearts For EVERY Item Taken! | 1,276 | | The Binding of Isaac: Rebirth
|
| 378. | What Happens If I Void Every Active Item In The Game?! | 1,266 | |
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| 379. | This Mod Changes Everyting! The Binding Of Isaac: Revelations! | 1,255 | | The Binding of Isaac: Rebirth
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| 380. | This New Death Certificate D6 Is BROKEN! | 1,252 | | The Binding of Isaac: Rebirth
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| 381. | This New Cube Turnes Enemies Into Items!? Epiphany Challenge #7 | 1,249 | | The Binding of Isaac: Rebirth
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| 382. | The Most BROKEN Character Ever! Mei Gameplay! | 1,245 | | The Binding of Isaac: Rebirth
|
| 383. | This New Boiler Floor Changes Everything! | 1,241 | | The Binding of Isaac: Rebirth
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| 384. | I Tried The Most Intense Challenge In Isaac History... | 1,203 | | The Binding of Isaac: Rebirth
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| 385. | They Added A New Alternative Angel Boss And It's Amazing! | 1,193 | | The Binding of Isaac: Rebirth
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| 386. | This New Character Has The Most Satisfying Synergies! Tainted Mei Gameplay! | 1,188 | | The Binding of Isaac: Rebirth
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| 387. | I Found The Easiest Way To Get Into All Rooms In Isaac! | 1,185 | | The Binding of Isaac: Rebirth
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| 388. | ONE ITEM GAME BREAK?! Tainted Isaac + Death Certificate! | 1,179 | | The Binding of Isaac: Rebirth
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| 389. | This New Item Gave Me The Best Familiars! | 1,166 | |
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| 390. | I Got New Tainted Samael Ending And It's INSANE! | 1,165 | | The Binding of Isaac: Rebirth
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| 391. | 2ND FILE MADNESS!! (ft. R Key start + RERUN unlock) | 1,144 | | The Binding of Isaac: Rebirth
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| 392. | Tainted Arachna Is Completely BROKEN! | 1,138 | | The Binding of Isaac: Rebirth
|
| 393. | This New Character Can Enchant Cards! Joseph Gameplay! | 1,136 | |
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| 394. | I Got The Luckiest Lost Soul Ever! | 1,126 | | The Binding of Isaac: Rebirth
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| 395. | This Is Why I Rig Every Run In Isaac! | 1,120 | | The Binding of Isaac: Rebirth
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| 396. | They Really Added Naruto In Isaac?! Epiphany Challenge #1 | 1,114 | | The Binding of Isaac: Rebirth
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| 397. | I Accidentally Became Satanic Mafia Boss In Isaac! | 1,095 | | The Binding of Isaac: Rebirth
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| 398. | The Deadliest Technology Synergy You Have Ever Seen! | 1,095 | Vlog | The Binding of Isaac: Rebirth
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| 399. | Can I Win With The Hardest Enemies Possible?! Retribution Challenge #2 | 1,093 | | Icarus
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| 400. | Isaac, But Every Time I Die I Get More Stats! | 1,091 | | The Binding of Isaac: Rebirth
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