| 301. | Notch's Son Plays Repentance! | 66 | | The Binding of Isaac: Rebirth
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| 302. | Singing Rick and Morty to Isaac’s Mom until she puts down the knife #Shorts | 66 | | The Binding of Isaac: Rebirth
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| 303. | Multimillionaire Reveals Secret To Success | 66 | |
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| 304. | Tainted Cain in a Nutshell | 65 | | The Binding of Isaac: Rebirth
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| 305. | Pica Run: The Coolest Repentance Challenge? | 65 | | The Binding of Isaac: Rebirth
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| 306. | The Eraser Makes The Matriarch a JOKE | 65 | | The Binding of Isaac: Rebirth
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| 307. | Playing Friday Night Funkin for the First Time EVER | 65 | | Friday Night Funkin'
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| 308. | Every Game Made By The Annoying Orange | 65 | | PewDiePie: Legend of the Brofist
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| 309. | PETA's Smash Bros Campaign | 64 | |
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| 310. | Low Damage Beast Fights are INTENSE | 64 | | The Binding of Isaac: Rebirth
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| 311. | Exploring the Home Floor In First Person | 64 | | The Binding of Isaac: Rebirth
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| 312. | ONE T JACOB RUN WITH NEW CHAIR | 63 | | The Binding of Isaac: Rebirth
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| 313. | Stitches + Tainted Forgotten is a MUST! | 63 | | The Binding of Isaac: Rebirth
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| 314. | Tainted Eve in a Nutshell | 62 | | The Binding of Isaac: Rebirth
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| 315. | What 1,000 Hours in Isaac Looks like | 62 | | The Binding of Isaac: Rebirth
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| 316. | New Greedier Bosses! | 62 | | The Binding of Isaac: Rebirth
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| 317. | ALL HAIL THE STAIRWAY | 62 | | The Binding of Isaac: Rebirth
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| 318. | Revisiting Wrath of the Lamb! | 61 | | The Binding of Isaac: Rebirth
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| 319. | New Planetarium Themed Character! - Andromeda | 61 | | The Binding of Isaac: Rebirth
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| 320. | Two VERY Lucky Ultra Secret Rooms Back to Back #Shorts | 61 | | The Binding of Isaac: Rebirth
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| 321. | I Want More of This Repentance Challenge: Cantripped! | 61 | | The Binding of Isaac: Rebirth
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| 322. | If Hush Was a Character | 61 | | The Binding of Isaac: Rebirth
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| 323. | World's Spiciest Isaac Memes | 61 | | The Binding of Isaac: Rebirth
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| 324. | Summoning Isaac Merch From Hell | 60 | | The Binding of Isaac: Rebirth
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| 325. | Non-Isaac Players Choose Items for me on the Ascent! | 60 | | The Binding of Isaac: Rebirth
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| 326. | Samson Before He Was Homeless | 60 | | The Binding of Isaac: Rebirth
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| 327. | Isaac on Mobile: Is it Better With a Controller? | 60 | | The Binding of Isaac: Rebirth
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| 328. | Very Weird Mother Glitch | 60 | | The Binding of Isaac: Rebirth
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| 329. | HELP ME | 60 | Let's Play | Minecraft
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| 330. | DEAD ESTATE HAS A DRESS UP GAME | 59 | | Dead Estate
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| 331. | What Happens if You Spam Wavy Cap? | 59 | | The Binding of Isaac: Rebirth
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| 332. | PETA's Bunny Raiders | 59 | |
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| 333. | Very Blessed Tainted Forgotten Run | 58 | | The Binding of Isaac: Rebirth
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| 334. | Flip is a Game Changer! | 58 | | The Binding of Isaac: Rebirth
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| 335. | Tainted Apollyon FLIES ONLY CHALLENGE | 57 | | The Binding of Isaac: Rebirth
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| 336. | Local Child Shoots Demon Fetus out of Her Stomach | 57 | | The Binding of Isaac: Rebirth
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| 337. | The Worst Way to Lose a Holy Mantle Shield | 57 | | The Binding of Isaac: Rebirth
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| 338. | Surprisingly Strategic Challenge: Red Redemption | 57 | | The Binding of Isaac: Rebirth
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| 339. | This Repentance Challenge Makes Me Anxious: Hot Potato | 57 | | The Binding of Isaac: Rebirth
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| 340. | I am Now the Best Jacob and Esau Player | 57 | | The Binding of Isaac: Rebirth
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| 341. | Does React Content Help Small YouTubers? | 57 | |
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| 342. | One Hour of Silence Broken Only by Blasphemy Against the Holy Spirit | 56 | | The Binding of Isaac: Rebirth
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| 343. | The BEST Defense in Isaac! | 56 | | The Binding of Isaac: Rebirth
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| 344. | Baby-Bender is AMAZING With Bethany | 56 | | The Binding of Isaac: Rebirth
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| 345. | Tainted Jacob is the Hardest Repentance Character Confirmed | 55 | | The Binding of Isaac: Rebirth
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| 346. | A Very Isaac Christmas! | 55 | | The Binding of Isaac: Rebirth
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| 347. | My First Ever Reaction to Hollow Knight!!! | 55 | | Hollow Knight
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| 348. | Weird Ragman Glitch | 55 | | The Binding of Isaac: Rebirth
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| 349. | When You've Been Playing T. Jacob for Way too Long | 54 | | The Binding of Isaac: Rebirth
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| 350. | The Luckiest Error Room Escape Ever!!! | 54 | | The Binding of Isaac: Rebirth
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| 351. | I Made a Harder Jacob and Esau! | 54 | | The Binding of Isaac: Rebirth
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| 352. | How Many Dark Esaus Can There Be at Once? | 54 | | The Binding of Isaac: Rebirth
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| 353. | mega blast +4.5 volt | 53 | | The Binding of Isaac: Rebirth
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| 354. | Artists Recreate Isaac Transformations! | 53 | | The Binding of Isaac: Rebirth
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| 355. | Top 10 Smoke Spots in Deltarune | 53 | | Deltarune
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| 356. | Mobile Games Seriously Need To Be Stopped | 53 | |
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| 357. | The Most Bizarre Visual Novel Ever | 53 | | The Pizza Delivery Boy Who Saved the World
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| 358. | A Game About Unlocking Achievements | 53 | | Achievement Unlocked
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| 359. | Mr. Beast Breaks a YouTube Record | 53 | |
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| 360. | Homing Creep is SO GOOD - Tainted Forgotten Greedier | 52 | | The Binding of Isaac: Rebirth
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| 361. | New Mysterious Character - Lairub | 52 | | The Binding of Isaac: Rebirth
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| 362. | Beware of Spear of Destiny! | 52 | | The Binding of Isaac: Rebirth
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| 363. | JoJo in The Binding of Isaac! | 51 | | The Binding of Isaac: Rebirth
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| 364. | Pokémon Drug Bust | 51 | |
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| 365. | Tainted Eve's Hidden Mechanic | 51 | | The Binding of Isaac: Rebirth
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| 366. | Baby Plum Reads Isaac a Bedtime Story | 51 | | The Binding of Isaac: Rebirth
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| 367. | TMTRAINER As a Playable Character! | 51 | | The Binding of Isaac: Rebirth
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| 368. | Edmund Blessed This Daily! - Day 2 | 51 | | The Binding of Isaac: Rebirth
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| 369. | T. Lost but I Shock Myself Every Time I Die | 50 | | The Binding of Isaac: Rebirth
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| 370. | My Life Sucks | 50 | |
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| 371. | We Failed... | 50 | |
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| 372. | An AI Insults Edmund McMillen | 50 | | The Binding of Isaac: Rebirth
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| 373. | Does Akinator Know The Binding of Isaac? | 50 | | The Binding of Isaac: Rebirth
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| 374. | OP Run With New Modded Character Job! | 50 | | The Binding of Isaac: Rebirth
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| 375. | Isaac Simps for Goth GF | 49 | | The Binding of Isaac: Rebirth
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| 376. | How Good is the Isaac New Grounds Demo? | 48 | | The Binding of Isaac: Rebirth
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| 377. | An AI watched 1,000 hours of Keelvin videos and here's what happened | 48 | | The Binding of Isaac: Rebirth
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| 378. | YouTube Now Has Video Games | 48 | |
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| 379. | Steamed Hams But its The Ascent in Isaac | 48 | | The Binding of Isaac: Rebirth
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| 380. | ACTUAL Dream Luck in Isaac! | 47 | | The Binding of Isaac: Rebirth
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| 381. | How Jaw Bone Can RUIN Your Run! | 47 | | The Binding of Isaac: Rebirth
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| 382. | Click for Epicness!!!! | 47 | | The Binding of Isaac: Rebirth
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| 383. | Are Pinhead's Chains Too Much? New Dead by Daylight Killer! | 47 | | Dead by Daylight
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| 384. | What's the New Tainted Cain Meta? | 47 | | The Binding of Isaac: Rebirth
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| 385. | THE NEW TAINTED LAZARUS IS AMAZING | 46 | | The Binding of Isaac: Rebirth
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| 386. | Here Comes the Boy | 46 | | The Binding of Isaac: Rebirth
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| 387. | Baby Plum Keeps Getting More Cursed... | 46 | | The Binding of Isaac: Rebirth
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| 388. | Blood Puppy is OVER POWERED | 46 | | The Binding of Isaac: Rebirth
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| 389. | Very Disturbing yet Very Fun Secret Repentance Character | 46 | | The Binding of Isaac: Rebirth
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| 390. | Solitar #162 | 46 | |
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| 391. | Opening Ed's Secret Package - The Unboxing of Isaac | 46 | | The Binding of Isaac: Rebirth
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| 392. | Crooked Penny + Car Battery Challenge is INSANE! | 46 | | The Binding of Isaac: Rebirth
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| 393. | Cursed Binding of Isaac Knock Off Games! | 45 | | The Binding of Isaac: Rebirth
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| 394. | Binding of Isaac Player Plays Enter The Gungeon For the First Time! | 45 | | Enter the Gungeon
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| 395. | Edmund Made an NFT? | 45 | | The Binding of Isaac: Rebirth
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| 396. | Try to Guess What This Mobile Game is About | 45 | | Five Nights at Freddy's
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| 397. | My MOST PATHETIC Tainted Lost Deaths | 45 | | The Binding of Isaac: Rebirth
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| 398. | The BEST Isaac Fan Game I've Ever Played - I.Rule | 45 | | The Binding of Isaac: Rebirth
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| 399. | Give Up (Good Ending) | 44 | |
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| 400. | Every Item is Lil Dumpy! | 44 | | The Binding of Isaac: Rebirth
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