| 1. |  YOGSCAST Kim | 6,503,643 | TACOMA: Compliance [ENDING] #5 | 38:44 |
| 2. |  Shenpai | 1,377,728 | An Easily Frightened Person Plays Alien: Isolation | 28:56 |
| 3. |  Gab Smolders | 1,175,814 | I beat Alien: Isolation on NIGHTMARE MODE | 1:10:12 |
| 4. |  Girls Play | 890,062 | FUNNY MOMENTS | Part 2 | Alien: Isolation | 14:31 |
| 5. |  Shizuka Rin Official | 653,382 | ありえん５ | 6:57:25 |
| 6. | TheRPGMinx | 298,946 | MAIZE + ALIENS ISOLATION! | 2:04 |
| 7. | Clare Siobhán | 141,773 | MY SCREAM BROKE THE MICROPHONE! - Alien Isolation - Survival Mode | 8:13 |
| 8. | Lomadiah | 128,459 | The Forest Co-op (with Sips) #5 - No Thanks, Spiders! | 17:18 |
| 9. |  Meghan Yeah | 119,112 | Another Underrated Spooky Horror Game? | VISAGE | 4:21:28 |
| 10. |  8 Bites | 108,130 | ALIEN ISOLATION BONUS EPISODE - Last Survivor | 20:23 |
| 11. | 39daph vods | 103,519 | 39daph Plays Alien: Isolation - Part 2 (Final) | 7:41:48 |
| 12. | Pandorya | 96,728 | NARCOSIS #03 - Die GEISTER die ich rief.. ● Let's Play Narcosis | 28:50 |
| 13. | Lavinia | 49,686 | The End -Ep 41 Let's Play: Alien Isolation | 22:26 |
| 14. | PressHeartToContinue | 43,793 | ALIEN ISOLATION HIGHLIGHTS: Spoopy Stream! | 9:35 |
| 15. | Geek Remix | 37,411 | ENDING - Womz Play Observations Part 6 | 55:29 |
| 16. | Eneija | 33,548 | Let's Play Alien: Isolation EP55 // STAIRWAY TO HAPPINESS [FINALE] | 26:41 |
| 17. | 有栖マナAlice mana | 30,899 | 【Alien: Isolation】#5 そろそろ終わらせてください | 4:44:53 |
| 18. |  Jana Gamer | 25,817 | BARATAS GIGANTES - JOGO DE TERROR - The Roach Apartment | 5:08 |
| 19. | Liera | 22,703 | ENDING - Playing Alien Isolation For the First Time l Hard Mode - Pt.14 | 59:36 |
| 20. |  Loserfruit | 17,070 | ALIEN ISOLATION SCREAM HIGHLIGHTS! | 3:04 |
| 21. |  Caiyth | 16,814 | CAN'T FIND THE BUTTON - ALIEN ISOLATION #17 | 12:00 |
| 22. | Liara Gaming | 11,432 | Running from the androids in Alien Isolation #shorts | 0:53 |
| 23. | InquisitorMaster | 11,111 | ONE MINUTE SPEEDRUN!! | Alien Isolation Survival Mode | 4:14 |
| 24. | Eversor Fatalis | 10,565 | FEET | 0:43 |
| 25. | GamerJoob | 7,631 | Alien Isolation Part: 8 Finale (Spooky with Jade) | 25:43 |
| 26. | Dandifying Gaming | 7,558 | SOMA Reaction Compilation | 12:29 |
| 27. | GamerKat09 | 6,131 | (P17 FINAL) Let's Play - Alien: Isolation [BLIND] - Verlaine?? | 1:10:00 |
| 28. | Ashley Mariee | 5,521 | Alien: Isolation | THE BEGINNING | Ep 1 w/ AshleyMariee | 15:42 |
| 29. | GirlFromAus | 4,950 | Alien Isolation Playthrough Part 11 - An Insane Ending | 1:18:39 |
| 30. | More2Me 4Life | 4,115 | Chat Controls Me | Alien Isolation Congregation Lite Modded | 10:26:35 |
| 31. |  Lexycutable | 4,049 | Syndrome - Take That Jimmy!!! | Part 16 *Final* | 45:39 |
| 32. | Angel Alyx | 3,686 | HAPPY LATE HALLOWEEN | Alien Isolation LIVE | 3:40:04 |
| 33. | OneRandomDolly | 2,947 | Alien Pen Drawing: Live Stream Alien Isolation | 3:01 |
| 34. | Fiaura The Tank Girl | 2,658 | Fiaura Alien Isolation Highlights | 37:18 |
| 35. |  Hai Halo Epel! | 2,480 | Senam Jantung Tidak Sehat【Alien: Isolation ft. @ReynardBlanc 】 | 2:58:35 |
| 36. | Connie K | 2,456 | Alien: Isolation | So we meet... | Part 3 | Connie Kuroi | 24:17 |
| 37. | My Cinnamon Phoe | 1,650 | Phoephoe FAILS to play Alien: Isolation Nightmare - I give up | 4:20 |
| 38. | Nerdlette Gaming | 1,579 | Alien: Isolation | Laney vs Alien Part 5 | 3:43:16 |
| 39. | ★WishingTikal★ | 1,533 | Detached PSVR Gameplay (PS4 VR) | 23:29 |
| 40. | Celina VODs | 1,303 | Will I Survive This? - Alien: Isolation (Full Playthrough Part 6) | 6:12:01 |
| 41. | GamerGirls | 1,218 | Alien Isolation Episode 44 - Back to the Beginning | 34:43 |
| 42. | Virgo4u | 1,178 | Alien Isolation | Part 23 | OH BOY!!! | 18:00 |
| 43. | DoubleDamsels | 1,136 | Double Damsels Play | Alien: Isolation | Part 8 | Two Weeks From Retirement | 10:23 |
| 44. | Kureha Kurono 黒乃くれは | 1,023 | 【 Horror 】Alien Isolation【 悲鳴 】#Vuber #JPVtuber | 3:18:56 |
| 45. |  AyinMaiden | 718 | My Alien Isolation Twitch Clips Compilation | 7:53 |
| 46. | The RPG Chick | 623 | Let's Play Tacoma (Blind), Part 1 of 12: Docked! | 28:31 |
| 47. |  KITSUNEKON | 599 | 《Alien: Isolation / 異形：孤立》和最喜歡的異形一起玩躲貓貓！【KITSUNEKON｜Gaming】 | 2:08:00 |
| 48. | lilly waters | 550 | Get'er Done Lets Play: Alien Isolation Part 38 reloaded | 19:06 |
| 49. | Nashtya Newb | 536 | Nash survives to the end in ALIEN: ISOLATION | Final | 57:35 |
| 50. |  BRM | 517 | Умный Чужой, хакеры и медитация | Alien: Isolation | Good MOMents | 20:57 |
| 51. | AssassinGlasgow | 428 | A Couple Let's Plays: Alien Isolation | ALIENS, ANDROIDS, NOOOOO [Pt. 3] | 15:04 |
| 52. | MsCarsonelle | 395 | Let's Try Alien Isolation (Starring My Brother!) | 22:16 |
| 53. | Unbealievable | 368 | Livestream Archive \\ Let's Play Alien: Isolation w/ My Girlfriend Janome \\ STOP BREATHING #3 | 1:32:16 |
| 54. | WTFSexyHeadphones | 273 | SOMA #13 Loud noies are bad noises | 27:56 |
| 55. | Riona Ch. EnVtuber | 230 | Alien Isolation - I WILL BE BRAVE THIS TIME. I WILL SHOW YOU GUYS I'M AFRAID OF NOTHING | 5:56:28 |
| 56. | DarkRubberNeck | 228 | I think I may have self destructed my pc lol - Alien Isolation Last Survivor - 02 | 14:32 |
| 57. | A Gallows | 152 | SO. MUCH. PRESSURE. | Alien Isolation | Part 3 | 56:23 |
| 58. | spookibree | 147 | livestreaming to convince myself not to quit youtube | 41:42 |
| 59. | くのいち子のちゃんねる | 146 | 【VISAGE #4】くのいち子は叫ばない2021 feat.ウパルマン殿(2021.10.11） | 2:59:33 |
| 60. | KTris Ch. | 118 | Twitch Stream- Alien Isolation (Full Edited Ver.) | 31:52 |
| 61. | Usagisquared Plays | 108 | Usagisquared Plays Alien: Isolation - Ep 32 | 29:41 |
| 62. | Tani | 107 | 👨🏻🚀Alien Isolation🔥 #09 Mit Feuer gegen das Alien | 3:09:51 |
| 63. | LadyTenjoin | 85 | Narcosis (First Person Horror Game) | Into the depths of the unknown...how fun | 43:03 |
| 64. | Mykal Marie Gameplays | 77 | SOMA - Part 2 - The Demons Have Arrived | 17:27 |
| 65. | Classy Katie | 77 | So dead! | 0:40 |
| 66. | mcrKirei | 42 | Alien: Isolation | Stream 2/21/16 | 2:38:28 |
| 67. | JezdaGames | 37 | The Forest -8- EEEEKKKK!!!! | 20:04 |
| 68. | KrimsonKitty | 14 | Couch Co-op with Mucs and Alien Isolation VR! Sub goal reward stream! | 3:43:02 |
| 69. | Nyxira | 14 | Something's Wrong with Emma!! | OBSERVATION | 4:18:54 |
| 70. | Mena Angelfire | 13 | Halloween Nights Day 17 Alien Isolation By Lady Amena | 27:30 |
