| 4-D Warriors (1985) | 10,643 | 82 |
| 4-Player Bowling Alley (1979) | 5,098 | 12 |
| 40 Winks (1999) | 2,030,043 | 1,068 |
| 404Sight (2015) | 123,698 | 117 |
| 41 Hours (2021) | 122,551 | 320 |
| 428: Shibuya Scramble (2008) | 3,472,244 | 6,707 |
| 44 Minutes in Nightmare (2021) | 4,701,593 | 406 |
| 47 HEROINES (2019) | 99,042 | 27 |
| 4D Prince of Persia (1994) | 108,693 | 18 |
| 4D Sports Boxing (1991) | 107,872 | 118 |
| 4D Sports Tennis (1990) | 9,163 | 22 |
| 4DSnake (2019) | 44 | 3 |
| 4P Ping-Pong (2012) | 335 | 2 |
| 4Prot (2021) | 0 | 0 |
| 4Sight (2019) | 31,724 | 8 |
| The 4th Coming (1999) | 36,006 | 60 |
| 4th Generation Warfare (2022) | 187,399 | 97 |
| 4th Super Robot Wars (1995) | 5,777,723 | 3,683 |
| 4x4 Evo (2000) | 331,265 | 354 |
| 4x4 Evo 2 (2001) | 692,631 | 530 |
| 4x4 Hummer (2009) | 1,638,858 | 74 |
| 4x4 Off-Road Racing (1987) | 340,145 | 169 |
| 5 A Day Adventures (1993) | 500 | 5 |
| 5 Days a Stranger (2003) | 2,818,928 | 508 |
| 5 in 1 Solitaire (2010) | 2,201 | 19 |
| 5 Spots (2003) | 10,815 | 45 |
| 5 Spots II (2003) | 8,416 | 5 |
| 5 Spots Party (2009) | 19,927 | 17 |
| 5 Star Fishy (2026) | 0 | 0 |
| 5 Star Miami Resort (2019) | 8,900 | 11 |
| 5 Star Rio Resort (2017) | 10,505 | 23 |
| 5-in-1 Arcade Hits (2010) | 18,804 | 21 |
| 5-Letter-Kruiswoord (1990) | 163 | 1 |
| 50 Cent: Blood on the Sand (2009) | 17,435,048 | 1,790 |
| 50 Cent: Bulletproof (2005) | 12,847,001 | 1,521 |
| 50 Classic Games (2009) | 20,364 | 41 |
| 50 Mission Crush (1984) | 15,087 | 54 |
| 500 cc Grand Prix (1986) | 306,219 | 37 |
| 505 Tangram (2011) | 655 | 2 |
| 51:22:51 (2023) | 394 | 3 |
| 5D Chess with Multiverse Time Travel (2020) | 10,496,648 | 852 |
| 5th Fleet (1994) | 5,847 | 12 |
| 5th Gear (1988) | 185,381 | 73 |
| 6 Feet Behind (2021) | 54 | 4 |
| 6 Inch My Darling (1998) | 33,609 | 16 |
| 6 Seasons and a Game (2021) | 37,247 | 54 |
| 6-in-1 IQ Scale Bundle (2018) | 398,093 | 184 |
| 6-Pak (1995) | 78,110 | 99 |
| 60 Parsecs! (2018) | 127,231,127 | 3,909 |
| 60 Seconds! (2015) | 1,212,247,516 | 12,674 |
| 60 Seconds! Reatomized (2019) | 272,982,160 | 6,439 |
| 6180 the moon (2014) | 73,416 | 140 |
| 64 de Hakken!! Tamagotchi: Minna de Tamagotchi World (1997) | 452,113 | 240 |
| 64 Hanafuda: Tenshi no Yakusoku (1999) | 72,194 | 28 |
| 64 Trump Collection: Alice no Waku Waku Trump World (1998) | 3,965 | 9 |
| 64.0 (2017) | 2,741,905 | 698 |
| 64th Street: A Detective Story (1991) | 412,894 | 744 |
| 688 Attack Sub (1989) | 141,846 | 111 |
| 69 Summon Succubus (2022) | 0 | 0 |
| 7 Billion Humans (2018) | 6,413,041 | 1,379 |
| 7 Blades (2000) | 154,028 | 252 |
| 7 Colors (1991) | 137,538 | 74 |
| 7 Days a Skeptic (2004) | 2,006,437 | 292 |
| 7 Days to Die (2013) | 2,319,808,177 | 870,791 |
| 7 Days To Save The World (2022) | 80 | 1 |
| 7 Dni a 7 noci (1994) | 1,763 | 1 |
| 7 Sins : Lost in Labyrinth (2023) | 55,038 | 38 |
| 7 Wonders 2 (2007) | 150,590 | 56 |
| 7 Wonders II (2008) | 82,223 | 51 |
| 7 Wonders of the Ancient World (2006) | 6,134,408 | 327 |
| 7 Wonders: Ancient Alien Makeover (2012) | 75,320 | 142 |
| 7 Wonders: Magical Mystery Tour (2011) | 63,015 | 49 |
| 7 Wonders: Treasures of Seven (2008) | 135,380 | 95 |
| 7 Years From Now (2017) | 779,274 | 2,236 |
| 7'scarlet (2016) | 892,290 | 544 |
