| 4 Soccer Simulators (1988) | 5,021 | 32 |
| 4 The Elements (2023) | 22,982 | 40 |
| 4 Travellers: Play French (2010) | 27 | 1 |
| 4 Travellers: Play Spanish (2010) | 0 | 0 |
| 4 Wheel Thunder (2000) | 80,078 | 193 |
| 4-D Warriors (1985) | 13,006 | 98 |
| 4-Player Bowling Alley (1979) | 5,091 | 10 |
| 40 Winks (1999) | 2,001,171 | 1,162 |
| 404Sight (2015) | 124,219 | 113 |
| 408 - The Forbidden Room (2021) | 30,083 | 13 |
| 41 Hours (2021) | 127,594 | 325 |
| 428: Shibuya Scramble (2008) | 3,442,364 | 7,499 |
| 44 Hidden Naomis (2025) | 0 | 0 |
| 44 Minutes in Nightmare (2021) | 4,683,014 | 407 |
| 44 The Jail (2024) | 20 | 3 |
| 47 HEROINES (2019) | 99,064 | 26 |
| 49 Keys (2024) | 1,967 | 18 |
| 4D Golf (2024) | 348,275 | 113 |
| 4D Prince of Persia (1994) | 108,511 | 17 |
| 4D Sports Boxing (1991) | 106,637 | 123 |
| 4D Sports Tennis (1990) | 8,588 | 19 |
| 4DSnake (2019) | 11 | 2 |
| 4P Ping-Pong (2012) | 336 | 2 |
| 4Prot (2021) | 0 | 0 |
| 4Sight (2019) | 28,261 | 5 |
| 4Tacos (2023) | 16 | 2 |
| The 4th Coming (1999) | 50,458 | 67 |
| 4th Era - The RuneChild (2025) | 0 | 0 |
| 4th Generation Warfare (2022) | 348,974 | 114 |
| 4th Super Robot Wars (1995) | 7,141,739 | 4,574 |
| 4x4 Evo (2000) | 288,513 | 346 |
| 4x4 Evo 2 (2001) | 714,742 | 537 |
| 4x4 Hummer (2009) | 644,054 | 106 |
| 4x4 Off-Road Racing (1987) | 324,512 | 162 |
| 5 A Day Adventures (1993) | 11,730 | 21 |
| 5 Days a Stranger (2003) | 2,917,407 | 528 |
| 5 Dice (2025) | 9,126 | 6 |
| 5 in 1 Solitaire (2010) | 2,504 | 16 |
| 5 Spots (2003) | 21,216 | 47 |
| 5 Spots II (2003) | 10,005 | 10 |
| 5 Spots Party (2009) | 20,965 | 17 |
| 5 Star Fishy (2026) | 0 | 0 |
| 5 Star Miami Resort (2019) | 8,923 | 10 |
| 5 Star Rio Resort (2017) | 10,320 | 23 |
| 5-in-1 Arcade Hits (2010) | 18,830 | 21 |
| 5-Letter-Kruiswoord (1990) | 163 | 1 |
| 50 Cent: Blood on the Sand (2009) | 19,068,641 | 2,059 |
| 50 Cent: Bulletproof (2005) | 12,018,366 | 1,718 |
| 50 Classic Games (2009) | 23,870 | 47 |
| 50 Mission Crush (1984) | 17,052 | 60 |
| 50 Pinch Barrage!! (2024) | 19,604 | 23 |
| 500 CALIBER CONTRACTZ (2025) | 22,731 | 36 |
| 500 cc Grand Prix (1986) | 24,636 | 32 |
| 505 Tangram (2011) | 729 | 3 |
| 51:22:51 (2023) | 394 | 3 |
| 5D Chess with Multiverse Time Travel (2020) | 9,841,897 | 898 |
| 5th Fleet (1994) | 4,725 | 10 |
| 5th Gear (1988) | 12,104 | 49 |
| 6 Feet Behind (2021) | 54 | 4 |
| 6 Inch My Darling (1998) | 14,296 | 12 |
| 6 Seasons and a Game (2021) | 37,141 | 49 |
| 6-in-1 IQ Scale Bundle (2018) | 16,145 | 23 |
| 6-Mon Adventure (2022) | 1,400 | 20 |
| 6-Pak (1995) | 73,091 | 86 |
| 6-Sided Stories (2024) | 177 | 5 |
| 60 Parsecs! (2018) | 129,347,366 | 3,954 |
| 60 Seconds! (2015) | 1,186,019,455 | 12,449 |
| 60 Seconds! Reatomized (2019) | 266,916,292 | 6,833 |
| 6180 the moon (2014) | 131,133 | 150 |
| 63 Days (2024) | 267,349 | 287 |
| 64 de Hakken!! Tamagotchi: Minna de Tamagotchi World (1997) | 461,475 | 295 |
| 64 Hanafuda: Tenshi no Yakusoku (1999) | 72,340 | 32 |
| 64 Trump Collection: Alice no Waku Waku Trump World (1998) | 5,043 | 13 |
| 64.0 (2017) | 3,454,372 | 717 |
| 64th Street: A Detective Story (1991) | 519,587 | 856 |
