| 4 Travellers: Play French (2010) | 27 | 1 |
| 4 Travellers: Play Spanish (2010) | 0 | 0 |
| 4 Wheel Thunder (2000) | 79,862 | 190 |
| 4-D Warriors (1985) | 11,208 | 93 |
| 4-Player Bowling Alley (1979) | 5,091 | 10 |
| 40 Winks (1999) | 1,987,673 | 1,137 |
| 404Sight (2015) | 124,214 | 113 |
| 408 - The Forbidden Room (2021) | 30,083 | 13 |
| 41 Hours (2021) | 127,594 | 325 |
| 428: Shibuya Scramble (2008) | 3,417,209 | 7,356 |
| 44 Hidden Naomis (2025) | 0 | 0 |
| 44 Minutes in Nightmare (2021) | 4,682,684 | 400 |
| 44 The Jail (2024) | 20 | 3 |
| 47 HEROINES (2019) | 99,064 | 26 |
| 49 Keys (2024) | 1,967 | 18 |
| 4D Golf (2024) | 346,243 | 108 |
| 4D Prince of Persia (1994) | 108,511 | 17 |
| 4D Sports Boxing (1991) | 106,541 | 121 |
| 4D Sports Tennis (1990) | 8,588 | 19 |
| 4DSnake (2019) | 11 | 2 |
| 4P Ping-Pong (2012) | 336 | 2 |
| 4Prot (2021) | 0 | 0 |
| 4Sight (2019) | 28,248 | 5 |
| 4Tacos (2023) | 16 | 2 |
| The 4th Coming (1999) | 49,253 | 65 |
| 4th Era - The RuneChild (2025) | 0 | 0 |
| 4th Generation Warfare (2022) | 346,018 | 113 |
| 4th Super Robot Wars (1995) | 6,948,640 | 4,453 |
| 4x4 Evo (2000) | 288,249 | 338 |
| 4x4 Evo 2 (2001) | 713,890 | 528 |
| 4x4 Hummer (2009) | 643,727 | 105 |
| 4x4 Off-Road Racing (1987) | 324,486 | 156 |
| 5 A Day Adventures (1993) | 8,695 | 20 |
| 5 Days a Stranger (2003) | 2,882,152 | 522 |
| 5 Dice (2025) | 9,080 | 6 |
| 5 in 1 Solitaire (2010) | 2,499 | 16 |
| 5 Spots (2003) | 21,216 | 47 |
| 5 Spots II (2003) | 10,005 | 10 |
| 5 Spots Party (2009) | 20,945 | 17 |
| 5 Star Fishy (2026) | 0 | 0 |
| 5 Star Miami Resort (2019) | 8,923 | 10 |
| 5 Star Rio Resort (2017) | 10,320 | 23 |
| 5-in-1 Arcade Hits (2010) | 18,813 | 21 |
| 5-Letter-Kruiswoord (1990) | 163 | 1 |
| 50 Cent: Blood on the Sand (2009) | 19,000,763 | 2,002 |
| 50 Cent: Bulletproof (2005) | 11,952,471 | 1,624 |
| 50 Classic Games (2009) | 23,830 | 47 |
| 50 Mission Crush (1984) | 17,052 | 60 |
| 50 Pinch Barrage!! (2024) | 19,604 | 23 |
| 500 CALIBER CONTRACTZ (2025) | 9,800 | 35 |
| 500 cc Grand Prix (1986) | 24,305 | 30 |
| 505 Tangram (2011) | 729 | 3 |
| 51:22:51 (2023) | 394 | 3 |
| 5D Chess with Multiverse Time Travel (2020) | 9,668,916 | 896 |
| 5th Fleet (1994) | 4,724 | 10 |
| 5th Gear (1988) | 11,999 | 48 |
| 6 Feet Behind (2021) | 54 | 4 |
| 6 Inch My Darling (1998) | 14,296 | 12 |
| 6 Seasons and a Game (2021) | 37,141 | 49 |
| 6-in-1 IQ Scale Bundle (2018) | 16,145 | 23 |
| 6-Mon Adventure (2022) | 1,400 | 20 |
| 6-Pak (1995) | 72,519 | 83 |
| 6-Sided Stories (2024) | 177 | 5 |
| 60 Parsecs! (2018) | 129,162,642 | 3,878 |
| 60 Seconds! (2015) | 1,176,092,089 | 12,362 |
| 60 Seconds! Reatomized (2019) | 266,499,433 | 6,748 |
| 6180 the moon (2014) | 131,130 | 150 |
| 63 Days (2024) | 265,831 | 285 |
| 64 de Hakken!! Tamagotchi: Minna de Tamagotchi World (1997) | 451,204 | 292 |
| 64 Hanafuda: Tenshi no Yakusoku (1999) | 72,340 | 32 |
| 64 Trump Collection: Alice no Waku Waku Trump World (1998) | 4,892 | 12 |
| 64.0 (2017) | 3,426,822 | 702 |
| 64th Street: A Detective Story (1991) | 450,211 | 829 |
| 688 Attack Sub (1989) | 146,335 | 111 |
| 69 Summon Succubus (2022) | 0 | 0 |
