| 4 Wheel Thunder (2000) | 79,099 | 177 |
| 4-D Warriors (1985) | 10,948 | 88 |
| 4-Player Bowling Alley (1979) | 5,091 | 10 |
| 40 Winks (1999) | 1,984,856 | 1,125 |
| 404Sight (2015) | 124,212 | 113 |
| 408 - The Forbidden Room (2021) | 30,083 | 13 |
| 41 Hours (2021) | 127,466 | 324 |
| 428: Shibuya Scramble (2008) | 3,405,674 | 7,219 |
| 44 Minutes in Nightmare (2021) | 4,682,594 | 399 |
| 44 The Jail (2024) | 20 | 3 |
| 47 HEROINES (2019) | 99,064 | 26 |
| 49 Keys (2024) | 1,415 | 15 |
| 4D Golf (2024) | 344,825 | 100 |
| 4D Prince of Persia (1994) | 108,511 | 17 |
| 4D Sports Boxing (1991) | 106,415 | 120 |
| 4D Sports Tennis (1990) | 8,588 | 19 |
| 4DSnake (2019) | 11 | 2 |
| 4P Ping-Pong (2012) | 336 | 2 |
| 4Prot (2021) | 0 | 0 |
| 4Sight (2019) | 28,231 | 5 |
| 4Tacos (2023) | 16 | 2 |
| The 4th Coming (1999) | 49,253 | 65 |
| 4th Generation Warfare (2022) | 344,745 | 108 |
| 4th Super Robot Wars (1995) | 6,580,975 | 4,312 |
| 4x4 Evo (2000) | 287,887 | 331 |
| 4x4 Evo 2 (2001) | 713,081 | 518 |
| 4x4 Hummer (2009) | 643,727 | 105 |
| 4x4 Off-Road Racing (1987) | 324,240 | 141 |
| 5 A Day Adventures (1993) | 8,695 | 20 |
| 5 Days a Stranger (2003) | 2,882,122 | 520 |
| 5 Dice (2025) | 9,068 | 6 |
| 5 in 1 Solitaire (2010) | 2,499 | 16 |
| 5 Spots (2003) | 21,190 | 46 |
| 5 Spots II (2003) | 10,005 | 10 |
| 5 Spots Party (2009) | 20,945 | 17 |
| 5 Star Fishy (2026) | 0 | 0 |
| 5 Star Miami Resort (2019) | 8,923 | 10 |
| 5 Star Rio Resort (2017) | 10,319 | 22 |
| 5-in-1 Arcade Hits (2010) | 18,813 | 21 |
| 5-Letter-Kruiswoord (1990) | 163 | 1 |
| 50 Cent: Blood on the Sand (2009) | 18,896,376 | 1,962 |
| 50 Cent: Bulletproof (2005) | 11,928,610 | 1,553 |
| 50 Classic Games (2009) | 19,738 | 43 |
| 50 Mission Crush (1984) | 17,052 | 60 |
| 50 Pinch Barrage!! (2024) | 19,602 | 22 |
| 500 CALIBER CONTRACTZ (2025) | 7,679 | 31 |
| 500 cc Grand Prix (1986) | 23,606 | 29 |
| 505 Tangram (2011) | 729 | 3 |
| 51:22:51 (2023) | 394 | 3 |
| 5D Chess with Multiverse Time Travel (2020) | 9,426,552 | 895 |
| 5th Fleet (1994) | 4,665 | 9 |
| 5th Gear (1988) | 11,988 | 48 |
| 6 Feet Behind (2021) | 54 | 4 |
| 6 Inch My Darling (1998) | 14,296 | 12 |
| 6 Seasons and a Game (2021) | 37,141 | 49 |
| 6-in-1 IQ Scale Bundle (2018) | 16,138 | 23 |
| 6-Mon Adventure (2022) | 1,400 | 20 |
| 6-Pak (1995) | 71,769 | 79 |
| 6-Sided Stories (2024) | 177 | 5 |
| 60 Parsecs! (2018) | 128,808,830 | 3,791 |
| 60 Seconds! (2015) | 1,174,798,967 | 12,267 |
| 60 Seconds! Reatomized (2019) | 265,477,006 | 6,645 |
| 6180 the moon (2014) | 131,130 | 150 |
| 63 Days (2024) | 265,384 | 284 |
| 64 de Hakken!! Tamagotchi: Minna de Tamagotchi World (1997) | 374,530 | 289 |
| 64 Hanafuda: Tenshi no Yakusoku (1999) | 72,340 | 32 |
| 64 Trump Collection: Alice no Waku Waku Trump World (1998) | 4,889 | 12 |
| 64.0 (2017) | 3,395,621 | 668 |
| 64th Street: A Detective Story (1991) | 448,092 | 805 |
| 688 Attack Sub (1989) | 146,277 | 108 |
| 69 Summon Succubus (2022) | 0 | 0 |
| 7 Billion Humans (2018) | 5,121,959 | 1,417 |
| 7 Blades (2000) | 146,505 | 263 |
| 7 Colors (1991) | 316,858 | 39 |
| 7 Days a Skeptic (2004) | 1,895,534 | 297 |
