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| 3. |  jacksepticeye | SATURDAY NIGHT AT THE MOVIES | Destroy All Humans #4 | 3,573 | |
| 4. |  theRadBrad | DESTROY ALL HUMANS REMAKE Walkthrough Gameplay Part 1 - INTRO (2020) | 3,062 | Walkthrough |
| 5. |  ARIA KEOXER | اگه من آدم فضایی بودم 😂 | 2,878 | |
| 6. | GameSpot | Destroy All Humans Remake - 15 Minutes Of Cinematics And Extended Gameplay Demo | E3 2019 | 2,781 | |
| 7. |  8-BitRyan | THIS ALIEN GAME IS COMPLETELY OUTRAGEOUS (& hilarious) - Destroy All Humans! | 2,633 | |
| 8. |  Cycu1 | Destroy All Humans Remake vs Original Early Graphics Comparison [ E3 2019 ] | 2,628 | |
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| 10. | gameranx | Destroy All Humans - Before You Buy | 2,044 | |
| 11. | GameClips | DESTROY ALL HUMANS REMAKE Ending Final Boss Fight | 1,957 | |
| 12. |  KeysJore | Destroy All Humans Remake Gameplay Deutsch #01 - Aliens an die Macht | 1,937 | |
| 13. |  HandOfBlood | Menschheit HOBS genommen | Destroy All Humans | 1,781 | |
| 14. | Jim Sterling | Destroy All Humans - A Great Remake Of A Fun, Unfunny Game (Jimpressions) | 1,672 | |
| 15. |  GmanLives | Destroy All Humans Review - One Giant Leap For Remakes | 1,587 | Review |
| 16. | IGN | Destroy All Humans! Remake - Official Release Date Trailer | 1,456 | Preview |
| 17. | Call Me Kevin | destroy all humans remaster | 1,416 | |
| 18. |  Doctor Misho | فضائى هدفه تدمير البشر !! 😈 | 1,357 | |
| 19. | AngryJoeShow | Angry Joe Destroys All Humans! | 1,342 | |
| 20. | Nick930 | Destroy All Humans Remake vs Original | Direct Comparison | 1,340 | |
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| 22. |  SpyCakes | I Became an Alien & Destroyed Everything! - Destroy All Humans Remake Gameplay | 1,141 | |
| 23. | penguinz0 | Moist Meter | Destroy All Humans Remake | 1,115 | |
| 24. | TearofGrace | DESTROY ALL HUMANS, But the Physics Don't Work | 1,113 | |
| 25. | KeysJore | Destroy All Humans Remake Gameplay Deutsch #02 - Aliens sind unter uns | 1,100 | |
| 26. | MKIceAndFire | DESTROY ALL HUMANS REMAKE Gameplay Walkthrough Part 1 FULL DEMO [4K 60FPS PC] - No Commentary | 1,051 | Walkthrough |
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| 28. | Wow Such Gaming | Why You Wouldn't Survive Destroy All Humans' Furon Invasion (Remake) | 1,017 | |
| 29. | Godenot | O BILU QUER DESTRUIR A TERRA - Destroy All Humans! | 1,016 | |
| 30. | GamersPrey | Destroy All Humans! Remake - E3 2019 Gameplay Demo [HD 1080P] | 997 | |
| 31. | TheLoneGamer | AIUTIAMO GLI ALIENI A CONQUISTARE LA TERRA NEGLI ANNI 50 | Destroy all humans - ep. 01 | 971 | |
| 32. | IGN | 13 Minutes of Destroy All Humans! Remake Gameplay | 901 | |
| 33. | KeysJore | Destroy All Humans Remake Gameplay Deutsch #03 - Der Alien Clown | 880 | |
| 34. | KeysJore | Destroy All Humans Remake Gameplay Deutsch #04 - Sonde von hinten | 839 | |
| 35. | TmarTn2 | They FINALLY remade this game after 15 years.. | 777 | |
| 36. | The Completionist | Destroy All Humans: The All-American Alien | 775 | Review |
| 37. |  牛沢 | 伝説の作品が蘇る【デストロイオールヒューマンズ！ リメイク版】 | 755 | |
| 38. | IGN | Destroy All Humans! - Official Gameplay Trailer | 753 | Preview |
| 39. | DublandoCoisas | Área 51 - Fbi Invadiu Casa Do Dono Do Ataque! | 735 | |
| 40. | PlayStation | Destroy All Humans! (2020) - Release Trailer | PS4 | 703 | |
| 41. | Sir Swag | This week's news without the bullshit (Week 23 2019) | 700 | |
| 42. | Paveł | Destroy All Humans Gameplay PL [#3] SONDA w PUPĘ! CZŁOWIEKI Uciekają! | 688 | |
| 43. |  FavijTV | ALIEN SIMULATOR! | 686 | |
| 44. | MKIceAndFire | DESTROY ALL HUMANS REMAKE Gameplay Walkthrough Part 1 [1080p HD 60FPS PC] No Commentary (FULL GAME) | 665 | Walkthrough |
| 45. | OneyPlays | DESTROYING MORE HUMANS! | 657 | Let's Play |
| 46. | WhatCulture Gaming | 10 Video Games That Punish You For Being Smart | 653 | |
| 47. | BaronVonGames | DESTROY ALL HUMANS is Back! Destroy All Humans Gameplay Part 1 | 624 | |
| 48. | Febatista | SIMULADOR DE ALIEN! DESTRUA A HUMANIDADE | 607 | |
| 49. | IGN | Destroy All Humans! Review | 604 | Review |
| 50. | ACG | Destroy All Humans Review "Buy, Wait for Sale, Rent, Never Touch?" | 594 | Review |
| 51. | PlayStation | Destroy All Humans! - Cryptosporidium-137 presents: Fun with Guns | PS4 | 593 | |
| 52. | Godenot | BILU ABDUZ A MULHER MAIS BONITA DA CIDADE - Destroy All Humans! | 579 | |
| 53. | KeysJore | Destroy All Humans Remake Gameplay Deutsch #06 - Zombie Teenager Aliens | 576 | |
| 54. | Hollow | Destroy All Humans Remake - Part 1 - THIS GAME IS HILARIOUS 😂 | 573 | Walkthrough |
| 55. | KeysJore | Destroy All Humans Remake Gameplay Deutsch #05 - Muh-Kuh Terror | 570 | |
| 56. | GameClips | Crypto Finds Another Alien On Earth Scene - Destroy All Humans Remake | 560 | |
| 57. | TmarTn2 | Destroy All Humans - Part 1 - The Beginning | 557 | |
| 58. | MessYourself Gaming | DESTROY ALL HUMANS ...and cows | 553 | |
| 59. | Lusty | NE JOUEZ PAS A DESTROY ALL HUMANS 2020 !! | 547 | |
| 60. | KeysJore | Destroy All Humans Remake Gameplay Deutsch #07 - King of Rock and Roll | 544 | |
| 61. | IGN | Destroy All Humans! Remake: Full Demo Gameplay | 540 | |
| 62. | Ultimate Gamerz | Destroy All Humans Remake Vs Original Graphics Comparison (Extended Version) | 540 | |
| 63. | IGN | Destroy All Humans: What the Remake Changes and Improves - Gamescom 2019 | 539 | |
| 64. | Digital Foundry | Destroy All Humans! 2020 Remake vs 2005 Original - An Unreal Transformation! [Sponsored] | 534 | |
| 65. |  iXBT games | Тупо. Весело. Бесчеловечно. Обзор Destroy All Humans! | 533 | |
| 66. | xQc | DESTROY ALL HUMANS! - xQcOW Full Playthrough | xQcOW | 516 | Let's Play |
| 67. | MattShea | Abducting a Human so I can... Probe Her ( ͡° ͜ʖ ͡°) (Destroy All Humans) | 506 | |
| 68. | TheLoneGamer | BATTAGLIA FINALE CONTRO IL ROBO-PRESIDENTE ED IL CAPO DEI MEN IN BLACK | Destroy all humans - ep. 09 | 501 | |
| 69. | SoyUnNoobTV | Destruye a los Humanos | 484 | |
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| 71. | Godenot | BILU DESTRÓI FESTA NA PISCINA - Destroy All Humans! | 471 | |
| 72. | Worth A Buy | Destroy all Humans Review - (2020 remake) | 467 | Review |
| 73. | MrMattyPlays | Destroy All Humans REMAKE Is EXACTLY What It NEEDS To Be | 465 | |
| 74. | Nuba Player | Destroy All Humans 2020 ,АНАЛЬНЫЙ ЗОНД #2 !!!ЭЛВИС УБИВАЕТ!!! | 461 | |
| 75. | TheLoneGamer | MUCCHE ZOMBIE RADlOATTIVE, TESTE CHE ESPL0DONO E I MALVAGI MEN IN BLACK | Destroy all humans - ep.02 | 447 | |
| 76. | xChaseMoney2 | "Destroy All Humans" Remake Walkthrough Gameplay Part 1 - Intro (2020) | 447 | Walkthrough |
| 77. | ViteC ► Play | УНИЧТОЖИТЬ ВСЕХ ЧЕЛОВЕКОВ! ► Destroy All Humans | 443 | |
| 78. | MKIceAndFire | DESTROY ALL HUMANS REMAKE Gameplay Walkthrough Part 1 FULL GAME [4K 60FPS PC] - No Commentary | 441 | Walkthrough |
| 79. | MaxPalaro | DESTRUINDO A HUMANIDADE em Destroy All Humans | 437 | |
| 80. | LioN KoLLA | පිටසක්වලින් | Destory All Human 👽 | 428 | |
| 81. | Gamer's Little Playground | DESTROY ALL HUMANS REMAKE All Cutscenes (Game Movie) PC 4K 60FPS UltraHD | 424 | |
| 82. | KeysJore | Destroy All Humans Remake Gameplay Deutsch #10 - Crypto 136 | 423 | |
| 83. | Cvit | Destroy All Humans PS2 vs Remake: The Gold Standard Remake | 419 | |
| 84. |  THQ Nordic | Destroy All Humans! - Release Date Trailer | 415 | Preview |
| 85. | TheLoneGamer | SCOPRIAMO I SEGRETI DEI MEN IN BLACK CON LA NUOVA SONDA "RETRÒ" | Destroy all humans - ep. 03 | 413 | |
| 86. | GameNews PlayStation | PS4 - Destroy All Humans! Trailer (E3 2019) | 410 | Preview |
| 87. |  Wedry | ÚKOL: ZNIČIT CELÉ LIDSTVO!! | 410 | |
| 88. | Lucky Salamander | DESTROY ALL HUMANS REMAKE - Caçando a Humanidade!!! [ DEMO - PC Gameplay 4K ] | 408 | |
| 89. | KeysJore | Destroy All Humans Remake Gameplay Deutsch #11 - Rettung Crypto 136 | 403 | |
| 90. | TheProfessional | Destroy All Humans Remake Part 1- Landing On Earth | 401 | |
| 91. | TearofGrace | DESTROY ALL HUMANS But the Game Breaks Constantly... | 401 | |
| 92. |  PlayWithRega | ALIEN MENJAJAH BUMI VERSI REMAKENYA KEREN BANGET - DESTROY ALL HUMANS REMAKE INDONESIA | 395 | |
| 93. | HUEstation | Simulador de Comunista Alienígena - Destroy All Humans! | 388 | |
| 94. |  ElilobosMortal ヅ | Un juego de Aliens donde eres el ALIEN xddd - Destroy All Humans Remake (Mejores momentos) | 388 | |
| 95. | Drae | The Little Green Spacemen Are Back! - Destroy All Humans! Remake (Part 1) | 385 | |
| 96. | KeysJore | Destroy All Humans Remake Gameplay Deutsch #09 - Krieg der Welten | 371 | |
| 97. |  2BOF | להשמיד את כל בני האדם! | 370 | |
| 98. | Wolfy Playz | Destroying all Humans | 368 | |
| 99. | BereghostGames | COW TIPPING in DESTROY ALL HUMANS #1 | 367 | |
| 100. | Freequense | با فضایی ها همدست شدم - Destroy all humans | 367 | |
