| 1. |  GameGrumps | Maniac Mansion: Slinking in the Kitchen - PART 1 - Game Grumps | 863,474 | |
| 2. | Cinemassacre | Maniac Mansion (NES) James & Mike Mondays | 852,968 | |
| 3. | GameGrumps | Maniac Mansion: Tentacle Trouble - PART 2 - Game Grumps | 557,668 | |
| 4. | GameGrumps | Maniac Mansion: New Kid - PART 3 - Game Grumps | 489,568 | |
| 5. | GameGrumps | Maniac Mansion: Special Delivery - PART 4 - Game Grumps | 455,650 | |
| 6. | GameGrumps | Maniac Mansion: Finale - PART 5 - Game Grumps | 435,303 | |
| 7. |  Censored Gaming | 8 Weird Ways Nintendo Forgot To Censor NES Games | 388,048 | |
| 8. | IGN | This New NES Game Is for Adults Only | 336,813 | |
| 9. | Let's Play With Brigands | Let's Play Maniac Mansion (Full Playthrough) | 307,940 | Let's Play |
| 10. | KarmaJolt | Cheat to avoid capture in Maniac Mansion (NES) - A Wild Glitch Appears! #shorts | 284,388 | |
| 11. | X | NES Maniac Mansion - exploding hamster & Ed kills Syd | 183,725 | |
| 12. | Stan's Previously Owned Soundtracks | Monkey Island 2: LeChuck's Revenge - Full Soundtrack | 179,230 | |
| 13. | U Can Beat Video Games | #ManiacMansion Maniac Mansion NES - ULTIMATE GUIDE - ALL Endings, ANY Characters, SO MANY SECRETS! | 175,532 | Guide |
| 14. | World of Longplays | PC Longplay - Maniac Mansion (OLD RECORDING) | 167,071 | |
| 15. |  TheVR Gaming+ | Maniac Mansion: Day of the Tentacle || RETRO HÓNAP - 01.19. | 154,891 | |
| 16. | PushingUpRoses | Maniac Mansion: The Most Influential Game with Disembodied Tentacles | 154,796 | Review |
| 17. |  Halt and Catch Fire | Lucasfilm Games Historie – Wie die Macht der Adventures erwachte | 129,216 | |
| 18. |  Уютный подвальчик | Разве Dendy не компьютер?! | 118,603 | |
| 19. | Adventure Treff | Night of the Meteor Trailer | 116,035 | Preview |
| 20. | The Game Station | Adventures in Nintendo Censorship: Maniac Mansion - TGS | 112,999 | |
| 21. | World of Longplays | NES Longplay [252] Maniac Mansion | 112,890 | |
| 22. | Stan's Previously Owned Soundtracks | The Dig OST - Full Official Soundtrack | 107,507 | |
| 23. | PushingUpRoses | Wayne's World DOS Game? Shyeah Right. | 99,853 | Review |
| 24. | Rocket Beans Gaming | Maniac Mansion C64 (Training) Speedrun in 01:06:49 von Gregor | Speedrundale | 99,822 | |
| 25. | GameTrailers | Pop Fiction: Season 4: Episode 42: Maniac Mansion Hamster | 98,219 | Show |
| 26. | Syntactus | Maniac Mansion Intro | 86,362 | |
| 27. | wc10k | Let's Play Maniac Mansion (Nes) Part 1 | 82,883 | Let's Play |
| 28. | onaretrotip | 20 Essential DOS Adventure Games (ft. The Game Show) | 79,475 | Show |
| 29. | GameSpot | EFMS - History of Point and Click Adventures | 78,012 | |
| 30. |  slobulus | Nintendo NES - Recuerdos de la infancia y clásicos olvidados - Español | 75,314 | |
| 31. | CinnamonToastKen | Maniac Mansion - Tentacle Love! | 74,245 | |
| 32. | SayMaxWell | SayMaxWell - Maniac Mansion Theme [Remix] | 74,183 | |
| 33. | Rocket Beans Gaming | Sind meine Lieblingsspiele aus der Kindheit scheiße? | Retro Klub | 71,703 | |
| 34. | NRWBoy18 | Lets Play - Maniac Mansion (Deutsch) [Teil 1] | 71,034 | Let's Play |
| 35. | gTV_DE | Was war eigentlich das allererste Point & Click Adventure? | FIRSTS #29 mit David Hain | gTV | 70,684 | |
| 36. | gamervision | Maniac Mansion Trailer | 69,394 | Preview |
| 37. | PushingUpRoses | The Cave Review with PushingUpRoses | 64,960 | Review |
| 38. |  GlobiGame JDR | Le Fond De L'Affaire - Monkey Island | 60,970 | |
| 39. | PlayWithKate | NUTZLOSESTE Nerv-Items in Games | 60,389 | |
| 40. | Niko's 8BitStereo | Maniac Mansion (NES) Soundtrack - 8BitStereo | 60,072 | |
| 41. | Greg's RPG HeaveN | LET'S PLAY Maniac Mansion C64 // KOMPLETT 💿 Pack den Hamster in die Mikrowelle! (Deutsch) | 59,915 | Let's Play |
| 42. | PodcastOGRU | Золотой Период Адвенчур - Квесты начала 90-х - Old-Games.RU Podcast №75 | 59,249 | Show |
| 43. | Censored Gaming | Maniac Mansion Censorship - Censored Gaming Ft. Gnoggin | 55,422 | |
| 44. | NintendoCult | Maniac Mansion (Final Boss) -NES- | 51,157 | |
| 45. | Valcanal | MI historia de los VIDEOJUEGOS 1 (1 de 2) | 47,692 | |
| 46. | La Caverna del Gamer | 10 VIDEOJUEGOS estilo POINT & CLICK que son IMPRESCINDIBLES | 47,335 | |
| 47. |  arhn.eu | Jak powstawało Maniac Mansion -- Retro Ex | 46,260 | |
| 48. | nesguide | Maniac Mansion - NES Gameplay | 45,973 | |
| 49. | PushingUpRoses | Let's Play: Maniac Mansion [part 1] With Roo from Clan Of the Gray Wolf | 45,307 | Let's Play |
| 50. | MrVenom1974 | Maniac Mansion (C64/1987) {GERMAN} Part 1 - Ein ehrenwertes Haus [Let's Play] | 45,277 | Let's Play |
| 51. | CinnamonToastKen | Getting Pumped - Maniac Mansion | 44,195 | |
| 52. | CinnamonToastKen | Bernard NOOOOO! - Maniac Mansion | 43,918 | |
| 53. | CGRundertow | CGR Undertow - STICK IT TO THE MAN review for PlayStation 3 | 43,343 | Review |
| 54. | CinnamonToastKen | Meteor Police - Maniac Mansion | 38,955 | |
| 55. | GameSpot | Classic Studio Postmortem: Lucasfilm Games | 37,435 | |
| 56. | mailhunter | Maniac Mansion - INTRO | 37,420 | |
| 57. | Gaming History Source | Let's Compare ( Maniac Mansion ) | 37,317 | |
| 58. | Phil | Hamster + Mikrowelle = ? - Maniac Mansion | 35,555 | |
| 59. | Greg's RPG HeaveN | LET'S PLAY Sam & Max Hit the Road // KOMPLETT 💿 LucasArts durchgeknalltes Grafik-Adventure (Deutsch) | 33,697 | Let's Play |
| 60. | Anachon | Let's Play Indiana Jones und der letzte Kreuzzug (Deutsch) #01 - Das nächste Abenteuer! | 33,490 | Let's Play |
| 61. | Lyra | MANIAC MANSION: Alle Charaktere, Enden, Tode, Explosionen | Walkthrough | Deutsch | 31,871 | Walkthrough |
| 62. | GeraldD1985 | Maniac Mansion Nes Speedrun | 30,220 | |
| 63. | At0mium - Archives | RELOAD - Ep.3 : Maniac Mansion | 29,789 | |
| 64. | Rocket Beans Gaming | Einer der größten Games Klassiker aller Zeiten | Maniac Mansion mit Dennis | 29,449 | |
| 65. | NRWBoy18 | Lets Play - Indiana Jones und der letzte Kreuzzug [Teil 1] | 29,053 | Let's Play |
| 66. |  Marukatu! Retro games | FC『マニアックマンション』クリア-219本目【MANIAC MANSION】 | 28,702 | |
| 67. | Old Style Gaming | The 20 Best Commodore 64 Horror Games | 28,620 | |
| 68. | wc10k | Let's Play Maniac Mansion (Nes) Part 2 | 26,266 | Let's Play |
| 69. | ladygilwen | Let's Play Maniac Mansion Deluxe - Part 1: The Mansion | 26,100 | Let's Play |
| 70. | MON | SCHOCKTOBER: Maniac Mansion meets Stranger Things! - Unusual Findings - komplettes Playthrough | 26,058 | |
| 71. | JARM | La ÉLITE de LUCASARTS - Sus 20 mejores juegos [1 por saga] | 25,227 | |
| 72. | Винсент Хаябуса | AVGN in Maniac Mansion | 24,787 | |
| 73. | PushingUpRoses | Let's Play: Maniac Mansion [part 2] With Roo | 24,496 | Let's Play |
| 74. | James killer | Maniac mansion Ending 3 - Meteor-eater plant | 22,366 | |
| 75. |  Cannot be Tamed | Maniac Mansion (NES) - Retro Gaming Review | 21,948 | Review |
| 76. | NRWBoy18 | Lets Play - Maniac Mansion (Deutsch) [Teil 2] | 21,641 | Let's Play |
| 77. | Mike Shade | Maniac Mansion walkthrough | 21,528 | Walkthrough |
| 78. | ゆうしゃ | #1【実況】衝撃の迷作ホラー！？FCマニアックマンション実況【でいぶ】 | 21,328 | |
| 79. | PushingUpRoses | Let's Play Maniac Mansion [part 3] With Roo | 20,851 | Let's Play |
| 80. | PushingUpRoses | Let's Play: Maniac Mansion [Part 4] With Roo | 20,287 | Let's Play |
| 81. | wc10k | Let's Play Maniac Mansion (Nes) Part 3 | 20,283 | Let's Play |
| 82. | UntilWeWinChannel | Until We Win - Top 10 Hardest Adventure Games | 18,955 | |
| 83. | Le Jeu C'est Sérieux | Maniac Mansion Deluxe en français sur PC (1 de 5) | 18,875 | |
| 84. | JamesInDigital | Maniac Mansion Intro | 18,424 | |
| 85. | CuteFloor | Maniac Mansion | 18,400 | |
| 86. |  Julian Fortunato | Scooby-Doo Mystery Intro Ha Ha Carnival Sega Genesis | 18,167 | |
| 87. | wc10k | Let's Play Maniac Mansion (Nes) Part 4 | 17,674 | Let's Play |
| 88. | Justin credible | Day Of The Tentacle Remastered, Maniac Mansion | 17,661 | |
| 89. | Pat the NES Punk | Maniac Mansion (PC, 1987) Feat. brentalfloss - Video Games History | 17,394 | |
| 90. | James killer | Maniac mansion Ending 1 - Homemade space travel | 17,350 | |
| 91. | James killer | Maniac mansion Ending 2 - How to get rid of your boyfriend | 16,959 | Guide |
| 92. | Arcus | Maniac Mansion NES speedrun in 9:15 by Arcus | 16,948 | |
| 93. | PushingUpRoses | Let's Play: Maniac Mansion [Part 5] with Roo | 16,929 | Let's Play |
| 94. | MegaBubble's VGM+ B-) | Maniac Mansion (NES) - Dave's Theme Music | 16,863 | |
| 95. | NRWBoy18 | Lets Play - Maniac Mansion (Deutsch) [Teil 3] | 16,519 | Let's Play |
| 96. | GameSpot | Cave Diving with Ron Gilbert - Interview | 16,436 | |
| 97. | MrKravin | OH, IT'S CHRISTMAS? - Indie Horror Game | 16,401 | |
| 98. | Insert Coin | Maniac Mansion Spanish Version | 16,220 | |
| 99. | TheParappa | Der bunte 90er Jahre-Teenage-Werbespiel Retro Check (14 Jahre TheParappa auf YouTube) | 16,092 | |
| 100. | Pat the NES Punk | Maniac Mansion Boogie - Classic 4th Annual NES Marathon Moment | 15,742 | |
