| 1. |  GameGrumps | Maniac Mansion: Slinking in the Kitchen - PART 1 - Game Grumps | 1,581 | |
| 2. | Cinemassacre | Maniac Mansion (NES) James & Mike Mondays | 1,447 | |
| 3. | U Can Beat Video Games | #ManiacMansion Maniac Mansion NES - ULTIMATE GUIDE - ALL Endings, ANY Characters, SO MANY SECRETS! | 1,032 | Guide |
| 4. | GameGrumps | Maniac Mansion: Finale - PART 5 - Game Grumps | 826 | |
| 5. | PushingUpRoses | Maniac Mansion: The Most Influential Game with Disembodied Tentacles | 657 | Review |
| 6. |  Censored Gaming | 8 Weird Ways Nintendo Forgot To Censor NES Games | 633 | |
| 7. | GameGrumps | Maniac Mansion: New Kid - PART 3 - Game Grumps | 621 | |
| 8. | GameGrumps | Maniac Mansion: Tentacle Trouble - PART 2 - Game Grumps | 614 | |
| 9. | GameGrumps | Maniac Mansion: Special Delivery - PART 4 - Game Grumps | 552 | |
| 10. | Let's Play With Brigands | Let's Play Maniac Mansion (Full Playthrough) | 484 | Let's Play |
| 11. | Stan's Previously Owned Soundtracks | The Dig OST - Full Official Soundtrack | 314 | |
| 12. | The Game Station | Adventures in Nintendo Censorship: Maniac Mansion - TGS | 312 | |
| 13. |  Уютный подвальчик | Разве Dendy не компьютер?! | 292 | |
| 14. |  gTV_DE | Was war eigentlich das allererste Point & Click Adventure? | FIRSTS #29 mit David Hain | gTV | 281 | |
| 15. | onaretrotip | 20 Essential DOS Adventure Games (ft. The Game Show) | 279 | Show |
| 16. | IGN | This New NES Game Is for Adults Only | 262 | |
| 17. |  slobulus | Nintendo NES - Recuerdos de la infancia y clásicos olvidados - Español | 230 | |
| 18. | GameSpot | EFMS - History of Point and Click Adventures | 221 | |
| 19. | Stan's Previously Owned Soundtracks | Monkey Island 2: LeChuck's Revenge - Full Soundtrack | 215 | |
| 20. | Rocket Beans Gaming | Sind meine Lieblingsspiele aus der Kindheit scheiße? | Retro Klub | 208 | |
| 21. |  Cannot be Tamed | Maniac Mansion (NES) - Retro Gaming Review | 203 | Review |
| 22. | Old Style Gaming | The 20 Best Commodore 64 Horror Games | 199 | |
| 23. | Valcanal | MI historia de los VIDEOJUEGOS 1 (1 de 2) | 196 | |
| 24. | PodcastOGRU | Золотой Период Адвенчур - Квесты начала 90-х - Old-Games.RU Podcast №75 | 194 | Show |
| 25. | wc10k | Let's Play Maniac Mansion (Nes) Part 1 | 187 | Let's Play |
| 26. | PushingUpRoses | Wayne's World DOS Game? Shyeah Right. | 181 | Review |
| 27. | NRWBoy18 | Lets Play - Maniac Mansion (Deutsch) [Teil 1] | 177 | Let's Play |
| 28. | TheParappa | Der bunte 90er Jahre-Teenage-Werbespiel Retro Check (14 Jahre TheParappa auf YouTube) | 177 | |
| 29. | MrVenom1974 | Maniac Mansion (C64/1987) {GERMAN} Part 1 - Ein ehrenwertes Haus [Let's Play] | 167 | Let's Play |
| 30. | Niko's 8BitStereo | Maniac Mansion (NES) Soundtrack - 8BitStereo | 159 | |
| 31. | Adventure Treff | Night of the Meteor Trailer | 159 | Preview |
| 32. | gamervision | Maniac Mansion Trailer | 155 | Preview |
| 33. | onaretrotip | The Forgotten MANIAC MANSION Sitcom | 153 | |
| 34. | JARM | La ÉLITE de LUCASARTS - Sus 20 mejores juegos [1 por saga] | 146 | |
| 35. | La Caverna del Gamer | 10 VIDEOJUEGOS estilo POINT & CLICK que son IMPRESCINDIBLES | 137 | |
| 36. | World of Longplays | NES Longplay [252] Maniac Mansion | 134 | |
| 37. | Rocket Beans Gaming | Maniac Mansion C64 (Training) Speedrun in 01:06:49 von Gregor | Speedrundale | 124 | |
| 38. | MrVenom1974 | Das 1.000-Abo Special - Die Vorstellung - {GERMAN} | 123 | |
| 39. | PushingUpRoses | Let's Play: Maniac Mansion [part 1] With Roo from Clan Of the Gray Wolf | 122 | Let's Play |
| 40. | At0mium - Archives | RELOAD - Ep.3 : Maniac Mansion | 121 | |
| 41. | CinnamonToastKen | Maniac Mansion - Tentacle Love! | 117 | |
| 42. | JARM | Las sorprendentes AVENTURAS GRÁFICAS de NES | 117 | |
| 43. | World of Longplays | PC Longplay - Maniac Mansion (OLD RECORDING) | 115 | |
| 44. | KarmaJolt | Cheat to avoid capture in Maniac Mansion (NES) - A Wild Glitch Appears! #shorts | 110 | |
| 45. | PushingUpRoses | The Cave Review with PushingUpRoses | 108 | Review |
| 46. | MrVenom1974 | Maniac Mansion ReVisited #4: Hamster - Brust oder Keule /w. WiihawkLP [Let's Play] {GERMAN} | 107 | Let's Play |
| 47. | Greg's RPG HeaveN | LET'S PLAY Maniac Mansion C64 // KOMPLETT 💿 Pack den Hamster in die Mikrowelle! (Deutsch) | 106 | Let's Play |
| 48. | Halt and Catch Fire | Lucasfilm Games Historie – Wie die Macht der Adventures erwachte | 104 | |
| 49. |  arhn.eu | Jak powstawało Maniac Mansion -- Retro Ex | 102 | |
| 50. | slobulus | COMMODORE 64: Especial 30º Aniversario | 99 | |
| 51. | GameTrailers | Pop Fiction: Season 4: Episode 42: Maniac Mansion Hamster | 99 | Show |
| 52. | Hungry Goriya | #shorts NES Music Gone Wrong - Maniac Mansion Dave's Theme | hungrygoriya | 99 | |
| 53. | SayMaxWell | SayMaxWell - Maniac Mansion Theme [Remix] | 94 | |
| 54. | NintendoComplete | Maniac Mansion (NES) Playthrough | 91 | Let's Play |
| 55. | OS GAMES10 | Maniac Mansion - EU JOGO #396 | 91 | |
| 56. | Gaming History Source | Let's Compare ( Maniac Mansion ) | 89 | |
| 57. | Censored Gaming | Maniac Mansion Censorship - Censored Gaming Ft. Gnoggin | 88 | |
| 58. | Lame Genie - Video Game Music Covers | Maniac Mansion (Dave's Theme) - Cover | 86 | |
| 59. | PushingUpRoses | Let's Play: Maniac Mansion [part 2] With Roo | 85 | Let's Play |
| 60. | MrVenom1974 | MrVenom1974 | Five Fucking Thousand | 5.000 Abo-Special (oder so ähnlich) | 84 | |
| 61. | Arcus | Maniac Mansion NES speedrun in 9:15 by Arcus | 83 | |
| 62. | PlayWithKate | NUTZLOSESTE Nerv-Items in Games | 80 | |
| 63. | BitHead1000 | UNEXPECTED WALLET BUSTER!!!COMPLETE NES COLLECTION!! | 79 | |
| 64. | PushingUpRoses | Let's Play: Maniac Mansion [Part 4] With Roo | 78 | Let's Play |
| 65. |  Lord Paddle | Maniac Mansion (Amiga) - 18 - Les Aventures du Paddle (SUB FR/ENG) | 78 | |
| 66. | RetroCheats | (Maniac Mansion) Play as the Villians - Game Genie & Ram Cheat Codes | 77 | |
| 67. | ladygilwen | Let's Play Maniac Mansion Deluxe - Part 1: The Mansion | 73 | Let's Play |
| 68. | Lame Genie - Video Game Music Covers | Maniac Mansion (Edison Family's Theme) - Full Band Cover by Lame Genie | 73 | |
| 69. | Lyra | MANIAC MANSION: Alle Charaktere, Enden, Tode, Explosionen | Walkthrough | Deutsch | 72 | Walkthrough |
| 70. | BeatEmUps | Maniac Mansion Review - Quickie With Wood | 72 | Review |
| 71. | PushingUpRoses | Let's Play: Maniac Mansion [Part 5] with Roo | 71 | Let's Play |
| 72. | Pat the NES Punk | Maniac Mansion Boogie - Classic 4th Annual NES Marathon Moment | 69 | |
| 73. | Sinaloe | Let's Play Maniac Mansion - Episode 1 [deutsch german] | 69 | |
| 74. | TuberViejuner | Novedades para la semana que viene desde mi 486 ( por escrito ¡estoy sin voz :S! ) | 67 | |
| 75. | GeraldD1985 | Maniac Mansion Nes Speedrun | 67 | |
| 76. | PushingUpRoses | Let's Play: Maniac Mansion [Part 9] with Roo (BAD ENDING) | 66 | Let's Play |
| 77. | Rocket Beans Gaming | Einer der größten Games Klassiker aller Zeiten | Maniac Mansion mit Dennis | 65 | |
| 78. |  Central Pandora | Maniac Mansion - Retrogames | 64 | |
| 79. | GameTube | Unsere Lieblings-Entwickler: LucasArts - GT-Talk #19 | 63 | |
| 80. | PushingUpRoses | Let's Play: Maniac Mansion [part 10] with Roo (GOOD ENDING) | 63 | Let's Play |
| 81. | Smash JT | SCAM ALERT: Limited Run Games Manipulative Tactics EXPOSED! | 63 | |
| 82. | wc10k | Let's Play Maniac Mansion (Nes) Part 2 | 63 | Let's Play |
| 83. | Greg's RPG HeaveN | LET'S PLAY Sam & Max Hit the Road // KOMPLETT 💿 LucasArts durchgeknalltes Grafik-Adventure (Deutsch) | 62 | Let's Play |
| 84. | nfistfu | Maniac Mansion Nuclear Meltdown Version Comparison | 61 | |
| 85. | MON | SCHOCKTOBER: Maniac Mansion meets Stranger Things! - Unusual Findings - komplettes Playthrough | 61 | |
| 86. | X | NES Maniac Mansion - exploding hamster & Ed kills Syd | 61 | |
| 87. | wc10k | Let's Play Maniac Mansion (Nes) Part 11 Conclusion | 60 | Let's Play |
| 88. | Loading... | Maniac Mansion - jak powstała gra? | 59 | |
| 89. | CinnamonToastKen | Getting Pumped - Maniac Mansion | 59 | |
| 90. | Le Jeu C'est Sérieux | Maniac Mansion sur NES | 58 | |
| 91. | Cheeky Commodore Gamer | Commodore 64 | MANIAC MANSION (1987) | 57 | |
| 92. | slobulus | Maniac Mansion (NES) || IGN España (Análisis / Review) || Arqueología con Slobulus #32 | 57 | Review |
| 93. | CGRundertow | CGR Undertow - STICK IT TO THE MAN review for PlayStation 3 | 56 | Review |
| 94. | mailhunter | Maniac Mansion - INTRO | 56 | |
| 95. | Eponine Plays | Maneras de Morir... en Maniac Mansion | 53 | |
| 96. | MrVenom1974 | Maniac Mansion (NES/1990) {GERMAN} Part 1 - Viel Lärm um Nichts [Let's Play] | 52 | Let's Play |
| 97. | Gerion79 | Maniac Mansion (Amiga) "Schau ma mal" Quickie | 52 | |
| 98. | UntilWeWinChannel | Until We Win - Top 10 Hardest Adventure Games | 52 | |
| 99. | MrVenom1974 | Maniac Mansion (C64/1987) {GERMAN} Part 5 - Fast wie eine wilde Pool-Party [Let's Play] | 51 | Let's Play |
| 100. | MrVenom1974 | Maniac Mansion ReVisited #2: Schrei vor Glück /w. WiihawkLP [Let's Play] {GERMAN} | 51 | Let's Play |
