| 1. |  Smooth McGroove | Mega Man 2 - Dr. Wily Stage Acapella | 12,978 | |
| 2. | Gamechamp3000 | VG Myths - Can You Beat Rockman 2 Without Getting Hit? | 5,966 | |
| 3. | GameGrumps | Mega Man 2: Ash Man - PART 3 - Game Grumps | 5,230 | |
| 4. | GameGrumps | Mega Man 2: Death By Bubble - PART 1 - Game Grumps | 4,350 | |
| 5. | Smosh Games | MEGA MAN (Honest Game Trailers) | 4,034 | Preview |
| 6. | GameGrumps | Mega Man 2: Blind Lava Jumps - PART 2 - Game Grumps | 2,880 | |
| 7. | brentalfloss | Mega Man 2 TITLE With Lyrics - brentalfloss | 2,789 | |
| 8. | GameGrumps | Mega Man 2: Heat Man the Series - PART 5 - Game Grumps | 2,716 | |
| 9. | Smooth McGroove | Mega Man 2 - Metal Man Acapella | 2,550 | |
| 10. | GameGrumps | Mega Man 2: Finale - PART 11 - Game Grumps | 2,412 | |
| 11. | GameGrumps | Mega Man 2: Dinosaur Loogie Fun - PART 6 - Game Grumps | 2,405 | |
| 12. | GameGrumps | Mega Man 2: Quickly, Now - PART 4 - Game Grumps | 2,175 | |
| 13. | GameGrumps | Mega Man 2: Wily's a Jerk - PART 7 - Game Grumps | 2,051 | |
| 14. | GameGrumps | Mega Man 2: Crash and Burn - PART 9 - Game Grumps | 1,978 | |
| 15. | GameGrumps | Mega Man 2: Too Many Graphics - PART 8 - Game Grumps | 1,859 | |
| 16. | ColdBrew697 | Bit Brigade performing Mega Man 2 at MAGFest X | 1,788 | |
| 17. | RetroSFX Mashups | 'Terminator 2' dubbed with MEGA MAN 2 game sounds! | RetroSFX Mashups | 1,692 | |
| 18. | GameGrumps | Mega Man 2: Tangerine Sunsets - PART 10 - Game Grumps | 1,663 | |
| 19. | Taylor Davis | Dr. Wily's Castle (Mega Man 2) - Violin Cover - Taylor Davis | 1,435 | |
| 20. | Cinemassacre | Mega Man 2 (NES Video Game) Part 2 - James & Mike Mondays | 1,350 | |
| 21. | chuggaaconroy | lets play megaman2 prat 1 (APRIL FOOLS) | 1,309 | |
| 22. | Cinemassacre | Mega Man Ultra (NES) James & Mike Mondays | 1,298 | |
| 23. | J's Reviews | Is Mega Man 2 Overrated? | 1,200 | |
| 24. | SomecallmeJohnny | Johnny vs. Mega Man 2 | 1,177 | |
| 25. | Cinemassacre | Mega Man 2 (NES Video Game) Part 1 - James & Mike Mondays | 1,157 | |
| 26. | xDEFCONx | Megaman 2 - Wood Man (xDEFCONx Remix / Remake) | 1,135 | |
| 27. | St1ka | The Brazilian Mega Man | St1ka's Retro Corner | 1,102 | |
| 28. | Nathaniel Bandy | How Mega Man 2 TRIGGERS You! | 1,089 | |
| 29. | Bumbles McFumbles | Robot Masters Vs Net Navis - Who Has The Better Design? [Bumbles McFumbles] | 972 | |
| 30. | Stop Skeletons From Fighting | Mega Man 2's Brilliant & Historic Ending | Gettin' Super Nerdy [SSFF] | 859 | |
| 31. | U Can Beat Video Games | #Megaman2 #MegaManII #RockMan2 #NES Mega Man 2 - NES - Ultimate Guide! (Normal, Zipless) | 814 | |
| 32. | Boundary Break | Off Camera Secrets | Mega Man Series - Boundary Break ft. GameXplain | 813 | |
| 33. | OverClocked ReMix: Video Game Music Community | OC ReMix #1702: Mega Man 2 'Nuclear Flash' [Flash Man] by Juan Medrano & zircon | 793 | |
| 34. | LetsPlay | Megaman 2 SPEED RUN RACE - Let's Play | 790 | Let's Play |
| 35. | GaMetal | Wood Man Stage (Mega Man 2) - GaMetal Remix | 778 | |
| 36. | Niko's 8BitStereo | Mega Man 2 (NES) Soundtrack - 8BitStereo *OLD MIX* | 751 | |
| 37. | Maximilian Dood | Mega Man 2 KICKED MY ASS - Full Playthru | 708 | |
| 38. | Cinemassacre | Cinemassacre Animated - Everything's a Skull - Mega Man 2 | 685 | |
| 39. | CouchSoup | Nolan North and Troy Baker Mega Fail at Playing Mega Man 2 | 652 | Let's Play |
| 40. | Erin Plays | Mega Man 2 (NES) Robot Masters - Erin Plays | 628 | |
| 41. | bobvids | Masculist Man | 570 | |
| 42. | Arcus | Mega Man 2 NES speedrun in 30:33 by Arcus | 542 | |
| 43. | Big Ole Words | Strange Secrets Hidden in NES Games (Nintendo Entertainment System) | 533 | |
| 44. | Nintendo Unity | Mega Man 2 - Boss Rush (All Boss Fights, No Damage) | 526 | |
| 45. | IGN | Live Mega Man 2 Speedrun - Bit Brigade @ MAGFest X | 492 | |
| 46. | ProJared Plays! | Difficult Mode Cause I Don't Suck │ Mega Man 2 #1 | 468 | |
| 47. | RushJet1 | Mega Man 2 Cover Playthrough [60FPS] | 455 | |
| 48. | ScykohPlays | Mega Man 2 - WHY ARE THERE GLITCHES? | PART 1 | 431 | Let's Play |
| 49. | GeminiLaser | Mega Man 2 - Game Genie and Glitches | 411 | |
| 50. | Justazag Z | Just-A-Theory: What Mega Man 1 Robot Masters Became What Mega Man 2 Robot Masters? | 378 | |
| 51. | Erin Plays | Mega Man 2 (NES) Dr. Wily's Castle - Erin Plays | 377 | |
| 52. | FamilyJules | Mega Man 2 Intro/Theme Metal Guitar Cover | FamilyJules | 376 | |
| 53. | Lionmight | Mega Man 2 - Flashman Stage (Electric Violin & Electric Guitar Cover/Remix) || String Player Gamer | 374 | |
| 54. | ProJared Plays! | FINALE │ Mega Man 2 #3 | 363 | |
| 55. | NintendoCapriSun | Let's Play Megaman 2, Part 4: Takeadumponthetoilet | 345 | |
| 56. | ScykohPlays | Mega Man 2 - FINALE! | PART 5 | 337 | Let's Play |
| 57. | Artificialraven | Megaman II (NES) Ending | 332 | |
| 58. | Lionmight | Mega Man 2 - Air Man Stage (Electric Guitar & Violin Cover/Remix) || String Player Gamer | 330 | |
| 59. | Madlittlepixel | I PAID $11 For A RETRO Console That Can Only Play Mega Man 2... | 314 | |
| 60. | NintendoComplete | Mega Man 2 (NES) Playthrough - NintendoComplete | 312 | Let's Play |
| 61. | Lionmight | Mega Man 2 - Main Theme/Dr. Wily 1 (Orchestral Metal Cover/Remix) || String Player Gamer | 310 | |
| 62. | Nintendo of America | Nintendo eShop - Mega Man 2 Trailer | 308 | Preview |
| 63. | NintendoCapriSun | Let's Play Megaman 2 Part 1: Sunday Will Never Be The Same | 304 | Let's Play |
| 64. | brentalfloss | Crash Man (Mega Man 2) - Funk Remix - brentalfloss | 296 | |
| 65. | jan Misali | I can't beat Air Man! (エアーマンが倒せない translation) | 296 | |
| 66. | GeminiLaser | Mega Man 2 - Bloopers, Glitches, and Other Cool Stuff | 295 | |
| 67. | Jeremy Parish | Video Works | Get equipped with Master Piece: Mega Man 2 | NES Works 127 | 290 | Show |
| 68. | Etce | All Mega-Man 2 Boss Intros - Animated | 287 | |
| 69. | Displaced Gamers | Mega Man 2 - Quick Man A.I. Explained - Behind the Code | 274 | |
| 70. | ProJared Plays! | And Now The HARD Levels │ Mega Man 2 #2 | 274 | |
| 71. | Displaced Gamers | The Complex Code of Mega Man 2 and How Zipping Works - Behind the Code | 261 | |
| 72. | Stephen Chapman | Cheat Engine 6.4 Tutorial Part 1: Introduction to Scan Types | 259 | Tutorial |
| 73. | JohnRiggs | Megaman 2 Plug n' Play - Worth $20? | 258 | |
| 74. | GeminiLaser | Mega Man 2 - Part 1: Unnecessary Risks Are Fun! | 243 | |
| 75. | Kinda Funny Games | Colin and Greg Play Mega Man 2 - Teaching Tuesdays | 237 | |
| 76. | OverClocked ReMix: Video Game Music Community | OC ReMix #2121: Mega Man 2 'For You' [Dr. Wily Stage 1] by AkumajoBelmont | 236 | |
| 77. | Austin532 | Megaman 2 Soundtrack PART 2 | 234 | |
| 78. | RichaadEB | Mega Man 2: Airman's Theme || Metal Cover by RichaadEB | 232 | |
| 79. | Lionmight | Mega Man 2 - Metal Man Theme ft. xclassicalcatx & TeraCMusic (Orchestral) || String Player Gamer | 232 | |
| 80. | DashieXP2 | Random Thoughts #02 - Mega Man 2 | 231 | |
| 81. | Cinemassacre Clips | Mega Man 2 Hard Difficulty Live Stream with Mike Matei | 229 | |
| 82. | Sergio Elisondo - Sergio and the Holograms | Mega Man 2 - Dr. Wily Stage 1 Epic Cover | 229 | |
| 83. | Prime Shiem | The Mega Man Web Game You Never Heard Of | 219 | |
| 84. | DJ Incompetent | If Film Composers Produced Rockman 2? 🎧 S4E10 MEGAMAN 2 Superplay Mix ☆One Life Clear☆ ♬Remix OST♬ | 218 | |
| 85. | KarmaJolt | Mega Man 2 Pause Jumping - A Wild Glitch Appears! #shorts | 218 | |
| 86. | KappaSeltzer | Mega Man 2 in the Nutshell (Parody) | 208 | |
| 87. | GeminiLaser | Mega Man 2 - Part 3: Fearsome Robots Are Made of Bubbles and Wood | 205 | |
| 88. | ProtoMario | The Very Strange Mega Man 2 Plug in Play Arcade Cabinet? | 199 | |
| 89. | Blue Television Games | Mega Man vs. Bomberman?! | Mega Man CX | Rom Hack #2 | 197 | |
| 90. | GeminiLaser | Mega Man 2 - Part 6: My Mad Professor Is an Alien | 192 | |
| 91. | Mega Ran | Mega Ran- "Wily" (Mega Man 2) | 186 | |
| 92. | Overseer190 | Mega Man 2 as an 80's Dark Fantasy/Sci-Fi Film | 184 | |
| 93. | JShay Translations (ジェイ・シェイ) | Both Korone and Marine Getting Wrecked by Air Man in Mega Man 2 [Hololive] | 182 | |
| 94. | ScykohPlays | Mega Man 2 - EAT METAL! | PART 2 | 180 | Let's Play |
| 95. | Maximilian Dood | Capcom's Top Selling Games May Surprise You | 178 | |
| 96. | Joltzdude139 | Xyperus - Mega Man 2: Dr. Wily's Stage Theme Remix | 178 | |
| 97. | Games Done Quick | Mega Man 2 by coolkid in 29:14 SGDQ2019 | 175 | |
| 98. | OceanBlueKirby | Mega Man 2 Music - Stage Select (NES) | 172 | |
| 99. | OverClocked ReMix: Video Game Music Community | Mega Man 2 OC ReMix by DDRKirby(ISQ): "Air Man's 9-bit Rock & Roll" [Air Man] (#3898) | 168 | |
| 100. | KarmaJolt | Warping to Wily Stage 2 in Mega Man 2 (NES) - A Wild Glitch Appears! (featuring MegaHarv) #shorts | 163 | |
