| 1. |  Wanderbots | Let's Play Opus Magnum - PC Gameplay Part 1 - Mindbender | 65,543 | Let's Play |
| 2. | KatherineOfSky | Opus Magnum Ep 1: IMPERIAL UNIVERSITY - Programming/Logic - First Look - Let's Play (Early Access) | 30,223 | Let's Play |
| 3. |  EnterElysium | OPUS MAGNUM Amazing Alchemist Game - Let's Look / Gameplay | 29,307 | Let's Play |
| 4. | EnterElysium | OPUS MAGNUM | HANGOVER CURE #01 Amazing Alchemist Game - Let's Play / Gameplay | 21,174 | Let's Play |
| 5. | EnterElysium | OPUS MAGNUM | MACHINE OIL #02 Amazing Alchemist Game - Let's Play / Gameplay | 10,728 | Let's Play |
| 6. | EnterElysium | OPUS MAGNUM | STAMINA POTION #03 Amazing Alchemist Game - Let's Play / Gameplay | 9,640 | Let's Play |
| 7. | Wanderbots | Let's Play Opus Magnum - PC Gameplay Part 6 - One Armed Wonder | 6,039 | Let's Play |
| 8. | Wanderbots | Let's Play Opus Magnum - PC Gameplay Part 7 - The Fall Of House Van Tassen | 4,945 | Let's Play |
| 9. | Stuff+ | Opus Magnum - Purification Programming Puzzle - Let's Play / Gameplay / Beverage | 2,793 | Let's Play |
| 10. | Wanderbots | Let's Play Opus Magnum - PC Gameplay Part 15 - Chain Link | 2,641 | Let's Play |
| 11. | Wanderbots | Let's Play Opus Magnum - PC Gameplay Part 16 - Topsy Turvy | 2,455 | Let's Play |
| 12. | Stuff+ | How Does Alchemy Work Again? | Opus Magnum - Let's Play / Gameplay | 1,627 | Let's Play |
| 13. | GQSmoos | Let's Play OPUS MAGNUM by Zachtronics #82 | SYNTHETIC MALACHITE | 324 | Let's Play |
| 14. | GQSmoos | Let's Play OPUS MAGNUM by Zachtronics #65 | HEXSTABILIZED SALT | 262 | Let's Play |
| 15. | GQSmoos | Let's Play OPUS MAGNUM by Zachtronics #84 | QUINTESSENTIAL MEDIUM | 234 | Let's Play |
| 16. | The Proximity | Opus Magnum Adventure || E15 || Explosive Phial [Let's Play] | 222 | Let's Play |
| 17. | Deer Darling | Alchemical Starts - Opus Magnum - Let's Play - Part 1 | 170 | Let's Play |
| 18. | GQSmoos | Let's Play OPUS MAGNUM by Zachtronics #67 | LAMPLIGHT GAS | 169 | Let's Play |
| 19. | GQSmoos | Let's Play OPUS MAGNUM by Zachtronics #69 | WELDING THERMITE | 169 | Let's Play |
| 20. | GQSmoos | Let's Play OPUS MAGNUM by Zachtronics #80 | HYPER VOLATILE GAS | 156 | Let's Play |
| 21. | GQSmoos | Let's Play OPUS MAGNUM by Zachtronics #81 | VANISHING MATERIAL | 153 | Let's Play |
| 22. | Dad's Gaming Addiction | DGA Plays: Opus Magnum (Ep. 1 - Gameplay / Let's Play) | 149 | Let's Play |
| 23. | GQSmoos | Let's Play OPUS MAGNUM by Zachtronics #62 | SUTURE THREAD | 144 | Let's Play |
| 24. | GQSmoos | Let's Play OPUS MAGNUM by Zachtronics #85 | SYNTHETIC MALACHITE (CENTERED PRODUCT CHALLENGE) | 143 | Let's Play |
| 25. | GQSmoos | Let's Play OPUS MAGNUM by Zachtronics #66 | LUSTRE | 135 | Let's Play |
| 26. | GQSmoos | Let's Play OPUS MAGNUM by Zachtronics #71 | REACTIVE GOLD | 134 | Let's Play |
| 27. | GQSmoos | Let's Play OPUS MAGNUM by Zachtronics #64 | TONIC OF HYDRATION | 131 | Let's Play |
| 28. | Deer Darling | Magnum Opus? - Opus Magnum - Let's Play - Part 18 | 129 | Let's Play |
| 29. | Deer Darling | Eyedrops of Revelation - Opus Magnum - Let's Play - Part 24 | 120 | Let's Play |
| 30. | GQSmoos | Let's Play OPUS MAGNUM by Zachtronics #72 | ASSASSIN'S FILAMENT | 116 | Let's Play |
| 31. | The Proximity | Opus Magnum Adventure || E00 || Prologue [Let's Play] | 108 | Let's Play |
| 32. | GQSmoos | Let's Play OPUS MAGNUM by Zachtronics #61 | WAKEFULNESS POTION | 101 | Let's Play |
| 33. | GQSmoos | Let's Play OPUS MAGNUM by Zachtronics #63 | BLOOD STANCHING POWDER | 96 | Let's Play |
| 34. | GQSmoos | Let's Play OPUS MAGNUM by Zachtronics #68 | CONDUCTIVE ENAMEL & LAMPLIGHT GAS REVISITED | 95 | Let's Play |
| 35. |  Keywii Plays | Keywii Plays Opus Magnum (1) | 90 | Let's Play |
| 36. | Marstead | ▶️ Start Playthrough - Opus Magnum [Blind] (Episode 1) | 85 | Let's Play |
| 37. | Deer Darling | Fontenelle's Observations & Sigmar's Garden - Opus Magnum - Let's Play - Part 19 | 80 | Let's Play |
| 38. | GQSmoos | Let's Play OPUS MAGNUM by Zachtronics #83 | EMBALMING FLUID | 80 | Let's Play |
| 39. | GQSmoos | Let's Play OPUS MAGNUM by Zachtronics #70 | VAN BERLO'S PIVOTS | 74 | Let's Play |
| 40. | GQSmoos | Let's Play OPUS MAGNUM by Zachtronics #74 | ALCHEMICAL SLAG | 69 | Let's Play |
| 41. | GQSmoos | Let's Play OPUS MAGNUM by Zachtronics #75 | EXPLOSIVE VICTRITE | 67 | Let's Play |
| 42. |  Hog Play | 27 OpusMagnum Blind Eyedrops Of Revelations | 66 | Let's Play |
| 43. | Jerp | Jerp plays Opus Magnum pt.1 - Alchemy at your service! (2021-01-22) | 60 | Let's Play |
| 44. | GQSmoos | Let's Play OPUS MAGNUM by Zachtronics #79 | ELECTRUM SEPERATION | 54 | Let's Play |
| 45. | GQSmoos | Let's Play OPUS MAGNUM by Zachtronics #77 | VISILLARY ANAESTHETIC | 54 | Let's Play |
| 46. | Hog Play | 03 OpusMagnum Blind Hangover | 51 | Let's Play |
| 47. | Nebu Pookins | Blind Let's Play - Opus Magnum Part 7 - Journal + Sigmar's Garden 2 | 47 | Let's Play |
| 48. | The Proximity | Opus Magnum Adventure || E31 || Alchemical Jewel [Let's Play] | 45 | Let's Play |
| 49. | Deer Darling | Beauty in Simplicity - Opus Magnum - Let's Play - Part 2 | 43 | Let's Play |
| 50. | Deer Darling | Curious Lipstick - Opus Magnum - Let's Play - Part 17 | 43 | Let's Play |
| 51. | The Proximity | Opus Magnum Adventure || E01 || Stabilzed Water [Let's Play] | 42 | Let's Play |
| 52. | The Proximity | Opus Magnum Adventure || E08 || Sigmar's Garden [Let's Play] | 42 | Let's Play |
| 53. | Deer Darling | Health & Stamina - Opus Magnum - Let's Play - Part 3 | 39 | Let's Play |
| 54. | The Proximity | Opus Magnum Adventure || E05 || Hangover Cure [Let's Play] | 37 | Let's Play |
| 55. | The Proximity | Opus Magnum Adventure || E24 || Very Dark Thread [Let's Play] | 36 | Let's Play |
| 56. | The Proximity | Opus Magnum Adventure || E02 || Refined Gold [Chapter 1 - Life in a Great House // Let's Play] | 35 | Let's Play |
| 57. | GQSmoos | Let's Play OPUS MAGNUM by Zachtronics #73 | VAPOROUS SOLVENT | 33 | Let's Play |
| 58. | Deer Darling | Crystal Timing - Opus Magnum - Let's Play - Part 15 | 33 | Let's Play |
| 59. | Deer Darling | Fragrant Poisons - Opus Magnum - Let's Play - Part 21 | 33 | Let's Play |
| 60. | Hog Play | 01 OpusMagnum Blind University | 33 | Let's Play |
| 61. | Jerp | Jerp plays Opus Magnum pt.4 - Ore Machinations (2021-01-31) | 32 | Let's Play |
| 62. | Deer Darling | Suspicious Viscious Sludge - Opus Magnum - Let's Play - Part 20 | 32 | Let's Play |
| 63. | Deer Darling | Rumblings of War - Opus Magnum - Let's Play - Part 4 | 32 | Let's Play |
| 64. | Keywii Plays | Keywii Plays Opus Magnum (2) | 31 | Let's Play |
| 65. | Deer Darling | Abrasive Vapor - Opus Magnum - Let's Play - Part 23 | 31 | Let's Play |
| 66. | Deer Darling | Model Alchemist - Opus Magnum - Let's Play - Part 26 | 30 | Let's Play |
| 67. | Deer Darling | Let's See the Fireworks! - Opus Magnum - Let's Play - Part 25 | 29 | Let's Play |
| 68. | The Proximity | Opus Magnum Adventure || E04 || Waterproof Sealant [Let's Play] | 29 | Let's Play |
| 69. | Deer Darling | "Courage Potion" - Opus Magnum - Let's Play - Part 5 | 29 | Let's Play |
| 70. | GQSmoos | Let's Play OPUS MAGNUM by Zachtronics #78 | MEDICINAL SOLVENT | 28 | Let's Play |
| 71. | Deer Darling | Live in the Shadows - Opus Magnum - Let's Play - Part 6 | 27 | Let's Play |
| 72. | The Proximity | Opus Magnum Adventure || E07 || Precision Machine Oil [Let's Play] | 26 | Let's Play |
| 73. | Nebu Pookins | Blind Let's Play - Opus Magnum Part 6 (Appendix Part 3) | 26 | Let's Play |
| 74. | Deer Darling | Fast Forward - Opus Magnum - Let's Play - Part 14 | 25 | Let's Play |
| 75. | Hog Play | 32 OpusMagnum Blind Reconstructed Solvent B | 25 | Let's Play |
| 76. | Deer Darling | Crown Jewels - Opus Magnum - Let's Play - Part 13 | 25 | Let's Play |
| 77. | Deer Darling | Alchemical Amaro - Opus Magnum - Let's Play - Part 22 | 25 | Let's Play |
| 78. | Jerp | Jerp plays Opus Magnum pt.3 - Let's add a dash of Thievery (2021-01-24) | 25 | Let's Play |
| 79. | The Proximity | Opus Magnum Adventure || E11 || Stamina Potion [Let's Play] | 24 | Let's Play |
| 80. | The Proximity | Opus Magnum Adventure || E06 || Airship Fuel [Let's Play] | 24 | Let's Play |
| 81. | muligan | Opus Magnum 2 | Hangover cure | 24 | Let's Play |
| 82. | Nebu Pookins | Blind Let's Play - Opus Magnum Part 2 (Chapter 4, first half of Chapter 5) | 24 | Let's Play |
| 83. | GQSmoos | Let's Play OPUS MAGNUM by Zachtronics #76 | LUSTROUS THREAD | 23 | Let's Play |
| 84. | Deer Darling | New Idea - Opus Magnum - Let's Play - Part 16 | 23 | Let's Play |
| 85. | Keywii Plays | Keywii Plays Opus Magnum (3) | 23 | Let's Play |
| 86. | The Proximity | Opus Magnum Adventure || E29 || Purified Gold [Let's Play] | 23 | Let's Play |
| 87. | Hog Play | 31 OpusMagnum Blind Reconstructed Solvent A | 23 | Let's Play |
| 88. | Deer Darling | Uncharted Territories - Opus Magnum - Let's Play - Part 8 | 23 | Let's Play |
| 89. | Deer Darling | Collision Course - Opus Magnum - Let's Play - Part 7 | 22 | Let's Play |
| 90. | The Proximity | Opus Magnum Adventure || E09 || Health Tonic [Let's Play] | 22 | Let's Play |
| 91. | The Proximity | Opus Magnum Adventure || E03 || Face Powder [Let's Play] | 22 | Let's Play |
| 92. | Deer Darling | Pure Gold - Opus Magnum - Let's Play - Part 12 | 22 | Let's Play |
| 93. | Hog Play | 26 OpusMagnum Blind Abrasive Particles | 21 | Let's Play |
| 94. | The Proximity | Opus Magnum Adventure || E24 || Life Sensing Potion [Let's Play] | 21 | Let's Play |
| 95. | Deer Darling | Long Chains & Hurt Brains - Opus Magnum - Let's Play - Part 9 | 20 | Let's Play |
| 96. | Game Fanatic | Opus Magnum - Helping With The War Effort | 20 | Let's Play |
| 97. | Hog Play | 30 OpusMagnum Blind Aether Detector | 20 | Let's Play |
| 98. | Hog Play | 29 OpusMagnum Blind Parade Rocket Fuel B | 19 | Let's Play |
| 99. | Hog Play | 20 OpusMagnum Blind Silver Paint | 19 | Let's Play |
| 100. | Jerp | Jerp plays Opus Magnum pt.6 - End of Anateus is just the beginning? (2021-02-05) | 18 | Let's Play |
