| 1. |  UberDanger | The Binding of Isaac Afterbirth+ review | 1,772,124 | Review |
| 2. |  Kirbyster | The Binding of Isaac Critique: An Extensive Look at the Unending Game +Interview with the Programmer | 424,491 | Review |
| 3. | IGN | The Binding of Isaac: Afterbirth+ Review | 409,125 | Review |
| 4. | IGN | The Binding of Isaac: Rebirth Review | 291,335 | Review |
| 5. | Luis Alamilla | The Binding of Isaac: Afterbirth+ Review | Nintendo Switch | 241,322 | Review |
| 6. | Chemicat Gaming | The Binding of Isaac: Afterbirth Plus Mod Review - Demonic Sigils (666 Sub Special) | 131,100 | Review |
| 7. | Mighty_Fahl | The KING of Rogue Likes | 118,414 | Review |
| 8. | Nyxson | 27 Best Overwhelmingly Positive Steam Games | 77,724 | Review |
| 9. | Chemicat Gaming | Auri, Enoch, The Blessed - NEW MODDED CHARACTERS! (300th video special!): Repentance Mod Review | 70,102 | Review |
| 10. | WIZZY | DOGMA, el mejor Boss de TBOI | Review y Opinión | 63,404 | Review |
| 11. | Chemicat Gaming | The Binding of Isaac: Repentance Mod Review - Lots of Guns! (Sniper, Machine Gun, Rocket Launcher) | 59,340 | Review |
| 12. | Northern Gaming | The Binding of Isaac: Repentance- Planetariums Rankings/Review (Fun) | 54,055 | Review |
| 13. | Chemicat Gaming | The Binding of Isaac: Afterbirth Plus Mod Review - Cesarean (Halloween Special But 3 Days Late) | 50,318 | Review |
| 14. |  Streview | עקידת יצחק - ביקורת - The Binding of Isaac Rebirth - Review - Hebrew | 49,510 | Review |
| 15. | Hidden Machine | I Put 3000 Hours Into This Game? | Binding of Isaac: Repentance Review | 43,910 | Review |
| 16. | Keelvin | Repentance 1 Year in - Retrospective & Review | 43,752 | Review |
| 17. | Chemicat Gaming | The Binding of Isaac: Afterbirth Plus Mod Review - Bertran (Part 1) | 43,696 | Review |
| 18. | Chemicat Gaming | The Binding of Isaac: Afterbirth Plus Mod Review - Deep Laboratories (+Soundtrack Mod!) | 40,055 | Review |
| 19. | Chemicat Gaming | The Binding of Isaac: Repentance Mod Review - The Stranger (CCC) | 39,160 | Review |
| 20. | BejeweledFern | Is The Binding Of Isaac Repentance WORTH IT? The binding of Isaac Repentance Review | 38,952 | Review |
| 21. | Classic L337 | 9MM Review (iPad & iPhone) | 38,401 | Review |
| 22. | Chemicat Gaming | Turn MONSTERS Into PLAYABLE CARDS in this Inscryption-Themed Mod! | TBoI: Repentance Mod Review | 37,274 | Review |
| 23. | Chemicat Gaming | The Binding of Isaac: Repentance Mini Mod Review - Wario Apparition | 35,871 | Review |
| 24. | Chemicat Gaming | The Lost Mod: Encore - Items, Enemies, and More | The Binding of Isaac: Afterbirth Plus Mod Review | 35,165 | Review |
| 25. |  FulltimeGames | TRÄNEN der ZERSTÖRUNG - The Binding of Isaac Rebirth/Afterbirth [FulltimeReview] | 31,989 | Review |
| 26. | The Library of Letourneau | can movie reviews be trusted? - Bits and Banter [01/08/2024] | 27,939 | Review |
| 27. | RGE | The Binding of Isaac: Rebirth - RGE | 26,762 | Review |
| 28. |  LordGatoG | ¿Vale La Pena Jugar The Binding Of Isaac Rebirth? | Análisis español | Review | 25,352 | Review |
| 29. | 8BE | The Binding of Isaac: Afterbirth+ (Nintendo Switch) Review | 8-Bit Eric | 23,820 | Review |
| 30. | Gamesear | The Binding Of Isaac: Afterbirth - Review | 23,453 | Review |
| 31. | bdLP | The Biggest Problem With This Community. | 22,744 | Review |
| 32. | Chemicat Gaming | SCP Mod Pack #1 (Enemies, items & more!) | The Binding of Isaac: Afterbirth Plus Mod Review | 21,330 | Review |
| 33. | Chemicat Gaming | The Binding of Isaac: Afterbirth Plus Mod Review - Bertran Part 2 (Christmas Special!) | 20,159 | Review |
| 34. |  KerneX | The Binding of Isaac: Rebirth #1 - Первые слезы | 17,329 | Review |
| 35. | SteveOHobo | The Binding of Isaac Rebirth - Review | 17,172 | Review |
| 36. | Chemicat Gaming | The Binding of Isaac: Afterbirth Plus Mod Review - Sewing Machine (Upgradable Familiars) | 15,557 | Review |
| 37. | Chemicat Gaming | The Binding of Isaac: Afterbirth Plus Mod Review - Eevee! (Eevee) | 15,518 | Review |
| 38. |  Random Game Reviews | Playing The Binding of Isaac For the First Time [Review] | 15,428 | Review |
| 39. | Chemicat Gaming | The Binding of Isaac: Afterbirth Plus Mod Review - Anthology (Pack One) | 14,360 | Review |
| 40. | Chemicat Gaming | The Binding of Isaac: Afterbirth Plus Mod Review - Anthology 2 (Pack Two) | 14,304 | Review |
| 41. | Chemicat Gaming | Fred's Eyes, Lil Fred, And A New Challenge! - Repentance Mod Review | 14,120 | Review |
| 42. | bdLP | FIRST PERSON MODE?!? - The Binding Of Isaac Mod Review #3 | 13,998 | Review |
| 43. | Purple Gaming | The Best Roguelike? | A Noita Review | 13,910 | Review |
| 44. | App Reviews - CrazyMikesapps | Fruit Ninja 2 Year Anniversary Update iPhone App Review - CrazyMikesapps | 13,763 | Review |
| 45. | Chemicat Gaming | This Mods Adds 4 New Unique Mega Mush Character Sprites! - Binding of Isaac: Repentance Mod Showcase | 13,664 | Review |
| 46. | Chemicat Gaming | Monstone - NEW MODDED BOSS! The Binding of Isaac: Repentance Mod Review | 13,076 | Review |
| 47. | WhatTheFnu | The Binding of Isaac Afterbirth - Fnu Reviews | 12,695 | Review |
| 48. | Dan Gheesling | First Look At - Binding of NLSS (Binding of Isaac Afterbirth Mod) | 12,549 | Review |
| 49. |  SwitchWatch | The Binding of Isaac Afterbirth+ switch review | 12,105 | Review |
| 50. | Chemicat Gaming | Haiiro (+ Synergies) - The Binding of Isaac: Afterbirth Plus Mod Review | 12,037 | Review |
| 51. | AppZialist | Dragons - Aufstieg von Berk - Android iPad iPhone App Gameplay Review [HD+] #96 ★ Lets Play | 10,109 | Review |
| 52. | AppZialist | Dragons - Aufstieg von Berk - Android iPad iPhone App Gameplay Review [HD+] #95 ★ Lets Play | 9,742 | Review |
| 53. | Chemicat Gaming | The Binding of Isaac: Afterbirth Plus Mod Review - Friendly Spider | 9,447 | Review |
| 54. | Chemicat Gaming | The Binding of Isaac: Afterbirth Plus Mod Review - Sins Jr. (Seniors) | 9,090 | Review |
| 55. |  pfupftheman | The Binding Of Isaac Review (Afterbirth, Rebirth, Repentance) | 8,842 | Review |
| 56. | AppZialist | Drachen Aufstieg von Berk - Android IOS iPad iPhone App Gameplay Review [HD+] #218 ★ Lets Play | 8,347 | Review |
| 57. | KerneX | The Binding of Isaac: Afterbirth #60 - Сид от подписчика | 8,221 | Review |
| 58. | Elise and Sam | Having a Lovely Chat Like the Good Old Days of Tea Review | Background Noise #1 | 7,342 | Review |
| 59. | AppZialist | Dragons - Aufstieg von Berk - Android iPad iPhone App Gameplay Review [HD+] #92 ★ Lets Play | 7,024 | Review |
| 60. | Hovac One | Wanda A Beautiful Apocalypse | Intro Part 1 PC Game Review | #wandagame | 6,810 | Review |
| 61. | Chemicat Gaming | The Binding of Isaac: Afterbirth Plus Mod Review - Sins Jr. (Juniors) | 6,799 | Review |
| 62. | Classic L337 | Infinite Warrior Review [iPhone & iPad] | 6,787 | Review |
| 63. | Kim Justice | Super Meat Boy + The Binding of Isaac: Ed McMillen's Modern Classics - Kim Justice | 6,730 | Review |
| 64. | AppZialist | Dragons - Aufstieg von Berk - Android IOS iPad iPhone App Gameplay Review [HD+] #201 ★ Lets Play | 6,514 | Review |
| 65. | Freedom! | ★ The Binding of Isaac: Rebirth Review ➜ Impulse | 5,758 | Review |
| 66. | Reviews 2 Go | The Binding of Isaac: Rebirth (PS Vita | PSTV) Video Review | 5,690 | Review |
| 67. | wiiviewr | Binding of Isaac: Afterbirth + Review (Nintendo Switch) | 5,665 | Review |
| 68. | Chemicat Gaming | The Binding of Isaac: Afterbirth Plus Mod Review - Pee Board (Additional Items + Characters) | 5,565 | Review |
| 69. | Egghead Productions | pOoR eGg GeTs DeStRoYeD bY aNgRy ReViEwEr | 5,541 | Review |
| 70. | Wolverous | Meine Gamescom 2016 - Das Review (inklu. The Binding Of Isaac Gameplay) | 5,246 | Review |
| 71. | AppZialist | Dragons - Aufstieg von Berk - Android iPad iPhone App Gameplay Review [HD+] #101 ★ Lets Play | 5,198 | Review |
| 72. | Chemicat Gaming | The Binding of Isaac: Afterbirth Plus Mod Review - Vortex Orb | 5,112 | Review |
| 73. | DannyDorito23 | Isaac's Tears GFUEL Flavor REVIEW! | 5,093 | Review |
| 74. | Chemicat Gaming | The Binding of Isaac: Afterbirth Plus Mod Review - Vibesaac | 5,033 | Review |
| 75. | Chemicat Gaming | The Binding of Isaac: Afterbirth Plus Mod Review - Holy Milk | 4,986 | Review |
| 76. | Chemicat Gaming | The Binding of Isaac: Afterbirth Plus Mod Review - Tech L | 4,883 | Review |
| 77. | Pocket Gamer | Naught 2 iOS iPhone / iPad Gameplay Review - AppSpy.com | 4,866 | Review |
| 78. | AppZialist | Dragons - Aufstieg von Berk - Android iPad iPhone App Gameplay Review [HD+] #82 ★ Lets Play | 4,635 | Review |
| 79. | Reviews 2 Go | The Binding of Isaac: Afterbirth + (Nintendo Switch) Review | 4,247 | Review |
| 80. | AppZialist | Dragons Aufstieg von Berk - Android IOS iPad iPhone App Gameplay Review [HD+] #249 ★ Lets Play | 4,238 | Review |
| 81. | Chemicat Gaming | The Binding of Isaac: Afterbirth Plus Mod Review - Black Mass | 4,233 | Review |
| 82. | KerneX | The Binding of Isaac: Rebirth #2 - Пакетик с кровью | 4,124 | Review |
| 83. | Chemicat Gaming | The Binding of Isaac: Afterbirth Plus Mod Review - Eevee! (Vaporeon) | 4,096 | Review |
| 84. | AppZialist | Dragons - Aufstieg von Berk - Android iPad iPhone App Gameplay Review [HD+] #110 ★ Lets Play | 3,958 | Review |
| 85. | Chemicat Gaming | The Binding of Isaac: Afterbirth Plus Mod Review - Luncheon (Tapeworm Boss) | 3,759 | Review |
| 86. | AppZialist | Dragons - Aufstieg von Berk - Android iPad iPhone App Gameplay Review [HD+] #119 ★ Lets Play | 3,725 | Review |
| 87. | AppZialist | Dragons - Aufstieg von Berk - Android iPad iPhone App Gameplay Review [HD+] #122 ★ Lets Play | 3,618 | Review |
| 88. | AppZialist | Dragons - Aufstieg von Berk - Android iPad iPhone App Gameplay Review [HD+] #107 ★ Lets Play | 3,609 | Review |
| 89. | AppZialist | Dragons - Aufstieg von Berk - Android IOS iPad iPhone App Gameplay Review [HD+] #199 ★ Lets Play | 3,526 | Review |
| 90. | AppZialist | Dragons - Aufstieg von Berk - Android iPad iPhone App Gameplay Review [HD+] #87 ★ Lets Play | 3,425 | Review |
| 91. | AppZialist | Dragons - Aufstieg von Berk - Android iPad iPhone App Gameplay Review [HD+] #121 ★ Lets Play | 3,417 | Review |
| 92. |  Neoanderson N-Gamz | The Binding of Isaac: Rebirth 3DS Test Video Review HD FR (N-Gamz) | 3,400 | Review |
| 93. | LinkyLess | THE BINDING of ISAAC es RARAMENTE ADICTIVO... y me gusta | Review | Linky | 3,245 | Review |
| 94. | AppZialist | Dragons - Aufstieg von Berk - Android iPad iPhone App Gameplay Review [HD+] #125 ★ Lets Play | 3,155 | Review |
| 95. | Chemicat Gaming | The Binding of Isaac: Afterbirth Plus Mod Review - Eevee! (Flareon) | 3,095 | Review |
| 96. | AppZialist | Dragons - Aufstieg von Berk - Android IOS iPad iPhone App Gameplay Review [HD+] #180 ★ Lets Play | 3,093 | Review |
| 97. |  PabloGamer20 | JOJO'S DIO AND THE WORLD MOD!-/The binding of isaac Afterbirth +/-(Mod Review en Español) | 3,026 | Review |
| 98. | AppZialist | Dragons - Aufstieg von Berk - Android IOS iPad iPhone App Gameplay Review [HD+] #153 ★ Lets Play | 2,985 | Review |
| 99. | Cataclysmic | An indepth showcase - Polarities review | 2,944 | Review |
| 100. | AppZialist | Dragons - Aufstieg von Berk - Android iPad iPhone App Gameplay Review [HD+] #109 ★ Lets Play | 2,890 | Review |
