| Twin Robots (2015) | 562,453 | 200 |
| Twin Ruin (2021) | 3,481 | 7 |
| Twin Sector (2009) | 383,890 | 348 |
| Twin Squash (1991) | 2,098 | 13 |
| Twin Stick Heroes (2021) | 549 | 6 |
| Twin Strike: Operation Thunder (2008) | 22,170 | 6 |
| TwinBee (1985) | 4,918,127 | 1,735 |
| Twinbee Portable (2007) | 19,787 | 21 |
| TwinBee RPG (1998) | 88,770 | 46 |
| TwinBee Taisen Puzzle-Dama (1994) | 49,398 | 34 |
| TwinBee Yahho! (1995) | 521,612 | 187 |
| TwinBlok (1996) | 305 | 6 |
| TwinCop (2019) | 13,744 | 23 |
| Twinity (2008) | 346,498 | 8 |
| Twinkle Hunter (2023) | 6,314 | 14 |
| Twinkle Star Sprites (1996) | 1,417,791 | 2,472 |
| Twinkle Star Sprites: La Petite Princesse (2005) | 84,015 | 112 |
| Twinkle Tale (1992) | 544,258 | 363 |
| The Twins (2020) | 616,578,092 | 7,638 |
| Twins Edge : Back and Forth (2022) | 1,547 | 2 |
| Twins of the Pasture (2017) | 1,226,254 | 22 |
| Twinsen's Little Big Adventure 2 Classic (2015) | 3,107 | 40 |
| Twinsen's Little Big Adventure Classic (2015) | 2,174 | 54 |
| Twintail on the Battlefield (2016) | 68,242 | 12 |
| Twinworld (1989) | 80,353 | 330 |
| Twinxoid (2005) | 914 | 2 |
| Twist of Destiny (2017) | 943,447 | 124 |
| Twisted Draw (2022) | 595 | 3 |
| Twisted Edge Extreme Snowboarding (1998) | 129,799 | 104 |
| Twisted Fusion (2016) | 17,238 | 89 |
| Twisted Lands: Insomniac (2011) | 42,156 | 108 |
| Twisted Lands: Origin (2012) | 37,353 | 91 |
| Twisted Lands: Shadow Town (2010) | 73,084 | 184 |
| Twisted Metal (1995) | 5,272,959 | 2,305 |
| Twisted Metal (2012) | 50,495,774 | 5,323 |
| Twisted Metal 2 (1996) | 15,940,403 | 8,002 |
| Twisted Metal 4 (1999) | 7,270,749 | 2,936 |
| Twisted Metal Black Online (2002) | 0 | 0 |
| Twisted Metal III (1998) | 4,705,630 | 1,941 |
| Twisted Metal: Black (2001) | 22,821,110 | 7,541 |
| Twisted Metal: Black (2002) | 1,284,980 | 209 |
| Twisted Metal: Head-On (2005) | 8,903,663 | 2,554 |
| Twisted Metal: Small Brawl (2001) | 2,445,810 | 1,049 |
| The Twisted Tales of Spike McFang (1993) | 1,969,719 | 459 |
| Twisted Worlds (2016) | 27,477 | 29 |
| Twisted: The Game Show (1993) | 116,496 | 46 |
| Twister (1986) | 24,112,398 | 772 |
| Twister Mania (2011) | 271,088 | 24 |
| Twister: Mother of Charlotte (1986) | 482 | 1 |
| TWISTEX (2024) | 2,603 | 14 |
| The Twisting Trail of Clues (2024) | 9 | 2 |
| Twisty Puzzle Simulator (2018) | 53,257 | 36 |
| Twisty Tracks (2004) | 10,169 | 3 |
| Twitch Sings (2019) | 11,146,317 | 1,304 |
| Twizzle Puzzle: Monkeys (2024) | 0 | 0 |
| Twizzle Puzzle: Rodents (2024) | 10 | 2 |
| Two Crude (1990) | 947,112 | 780 |
| Two Digits (2015) | 67,996 | 64 |
| Two Dots (2014) | 10,115,708 | 2,994 |
| Two Falls (Nishu Takuatshina) (2024) | 43,163 | 87 |
| Two Hands Eggs (2024) | 210 | 2 |
| Two Hot Chicks: an Erotica Porn Space Orgy! (2022) | 0 | 0 |
| Two Leaves and a bud - Tea Garden Simulator (2021) | 40,282 | 15 |
| Two Months of Devil King (2023) | 1,026 | 2 |
| Two Moon : Space Rabbit (2023) | 0 | 0 |
| Two of a Kind (2004) | 338,070 | 25 |
| Two Point Campus (2022) | 32,156,977 | 14,715 |
| Two Point Hospital (2018) | 152,453,969 | 34,444 |
| Two Point Museum (2025) | 4,333,120 | 2,279 |
| Two Strikes (2021) | 247,671 | 72 |
| Two Thrones (2004) | 361,389 | 94 |
| Two Tigers (1984) | 23,984 | 28 |
| Two Worlds (2007) | 10,861,956 | 3,737 |
| Two Worlds II (2010) | 19,513,877 | 6,505 |
| Two Worlds II Castle Defense (2011) | 60,872 | 78 |
