| Twinbee Portable (2007) | 19,875 | 22 |
| TwinBee RPG (1998) | 89,223 | 49 |
| TwinBee Taisen Puzzle-Dama (1994) | 50,739 | 35 |
| TwinBee Yahho! (1995) | 530,887 | 206 |
| TwinBlok (1996) | 305 | 6 |
| TwinCop (2019) | 13,744 | 23 |
| Twinity (2008) | 346,498 | 8 |
| Twinkle Hunter (2023) | 6,416 | 14 |
| Twinkle Star Sprites (1996) | 1,436,191 | 2,616 |
| Twinkle Star Sprites: La Petite Princesse (2005) | 85,892 | 119 |
| Twinkle Tale (1992) | 551,858 | 389 |
| The Twins (2020) | 622,958,956 | 8,452 |
| Twins Edge : Back and Forth (2022) | 1,547 | 2 |
| Twins of the Pasture (2017) | 1,238,205 | 23 |
| Twinsen's Little Big Adventure 2 Classic (2015) | 3,537 | 46 |
| Twinsen's Little Big Adventure Classic (2015) | 2,220 | 59 |
| Twintail on the Battlefield (2016) | 68,242 | 12 |
| Twinworld (1989) | 80,353 | 330 |
| Twinxoid (2005) | 1,110 | 4 |
| Twist of Destiny (2017) | 943,456 | 124 |
| Twisted Draw (2022) | 595 | 3 |
| Twisted Edge Extreme Snowboarding (1998) | 130,616 | 110 |
| Twisted Fusion (2016) | 17,345 | 90 |
| Twisted Lands: Insomniac (2011) | 42,236 | 109 |
| Twisted Lands: Origin (2012) | 37,427 | 92 |
| Twisted Lands: Shadow Town (2010) | 73,086 | 185 |
| Twisted Metal (1995) | 5,445,940 | 2,698 |
| Twisted Metal (2012) | 50,883,617 | 5,544 |
| Twisted Metal 2 (1996) | 17,660,535 | 8,693 |
| Twisted Metal 4 (1999) | 7,621,721 | 3,687 |
| Twisted Metal Black Online (2002) | 0 | 0 |
| Twisted Metal III (1998) | 5,297,521 | 2,607 |
| Twisted Metal: Black (2001) | 26,595,571 | 8,254 |
| Twisted Metal: Black (2002) | 1,301,773 | 209 |
| Twisted Metal: Head-On (2005) | 9,125,798 | 2,718 |
| Twisted Metal: Small Brawl (2001) | 2,517,085 | 1,165 |
| The Twisted Tales of Spike McFang (1993) | 1,974,566 | 497 |
| Twisted Worlds (2016) | 93,902 | 31 |
| Twisted: The Game Show (1993) | 116,738 | 49 |
| Twister (1986) | 24,244,105 | 797 |
| Twister Mania (2011) | 271,088 | 24 |
| Twister: Mother of Charlotte (1986) | 482 | 1 |
| TWISTEX (2024) | 2,603 | 14 |
| The Twisting Trail of Clues (2024) | 9 | 2 |
| Twisty Puzzle Simulator (2018) | 53,257 | 36 |
| Twisty Tracks (2004) | 10,169 | 3 |
| Twitch Sings (2019) | 11,151,598 | 1,309 |
| Twizzle Puzzle: Monkeys (2024) | 0 | 0 |
| Twizzle Puzzle: Rodents (2024) | 10 | 2 |
| Two Crude (1990) | 957,251 | 813 |
| Two Digits (2015) | 73,512 | 66 |
| Two Dots (2014) | 10,116,453 | 3,011 |
| Two Falls (Nishu Takuatshina) (2024) | 46,885 | 105 |
| Two Hands Eggs (2024) | 228 | 2 |
| Two Hot Chicks: an Erotica Porn Space Orgy! (2022) | 0 | 0 |
| Two Leaves and a bud - Tea Garden Simulator (2021) | 40,282 | 15 |
| Two Months of Devil King (2023) | 1,026 | 2 |
| Two Moon : Space Rabbit (2023) | 0 | 0 |
| Two of a Kind (2004) | 348,080 | 29 |
| Two Point Campus (2022) | 32,245,281 | 15,522 |
| Two Point Hospital (2018) | 152,792,058 | 35,669 |
| Two Point Museum (2025) | 6,672,086 | 5,078 |
| Two Sides of Hell (2026) | 19 | 1 |
