| Twerps (1982) | 9,574 | 4 |
| Twice Shy (1986) | 12,754 | 13 |
| Twilight City: Love as a Cure (2015) | 59,949 | 24 |
| Twilight Drive (2021) | 7,664 | 18 |
| Twilight Mahjongg (2002) | 142 | 2 |
| Twilight Monk (2025) | 9,790 | 4 |
| The Twilight of Infinity (2022) | 0 | 0 |
| Twilight Oracle (2024) | 8,258 | 54 |
| Twilight Parade: Moonlit Mononoke (2024) | 23,567 | 50 |
| Twilight Path (2018) | 254,106 | 112 |
| Twilight Phenomena: Strange Menagerie (2013) | 42,277 | 77 |
| Twilight Phenomena: The Incredible Show (2015) | 42,296 | 52 |
| Twilight Phenomena: The Lodgers of House 13 (2012) | 35,676 | 70 |
| Twilight Spirits (2017) | 1,213,174 | 176 |
| Twilight Struggle (2016) | 1,641,991 | 588 |
| Twilight Survivors (2024) | 209,566 | 629 |
| Twilight Syndrome Special (1998) | 37,275,892 | 52 |
| Twilight Syndrome Tansakuhen (1996) | 566,399 | 560 |
| Twilight Town: A Cyberpunk Day In Life (2021) | 3,906 | 8 |
| Twilight Wars (2009) | 251,125 | 422 |
| Twilight's Final Judgement (2023) | 70 | 3 |
| Twilight: 2000 (1991) | 183,886 | 142 |
| TwilightStar: Heart of Eir (2022) | 9,554 | 13 |
| Twin Blades (2009) | 2,239,609 | 395 |
| Twin Blades of the Three Kingdoms (2023) | 17,385 | 21 |
| Twin Breaker: A Sacred Symbols Adventure (2020) | 160,591 | 181 |
| Twin Caliber (2002) | 170,969 | 104 |
| Twin Cobra (1987) | 2,323,992 | 1,371 |
| Twin Cobra II (1995) | 150,334 | 119 |
| Twin Dragon (1998) | 303,799 | 333 |
| Twin Eagle (1988) | 211,411 | 252 |
| Twin Edge (2022) | 2,089,912 | 295 |
| Twin Goddesses (1994) | 936,071 | 205 |
| Twin Hawk (1989) | 371,002 | 393 |
| Twin Hobo Rocket (2008) | 146,328 | 5 |
| Twin Kingdom Valley (1983) | 11,193 | 13 |
| Twin Mind: Ghost Hunter (2022) | 188,798 | 135 |
| Twin Mind: Murderous Jealousy (2021) | 512,594 | 90 |
| Twin Mind: Nobody's Here (2022) | 62,862 | 155 |
| Twin Mind: Power of Love (2021) | 217,819 | 131 |
| Twin Mind: The Deathly Trick (2024) | 55,259 | 98 |
| Twin Mirror (2020) | 15,035,778 | 8,415 |
| The Twin Paradox (2024) | 1,521,383 | 91 |
| Twin Peaks VR (2019) | 92,913 | 50 |
| Twin Robots (2015) | 562,564 | 202 |
| Twin Ruin (2021) | 3,481 | 7 |
| Twin Sector (2009) | 384,227 | 393 |
| Twin Squash (1991) | 2,098 | 13 |
| Twin Stick Heroes (2021) | 549 | 6 |
| Twin Strike: Operation Thunder (2008) | 22,213 | 7 |
| TwinBee (1985) | 5,073,140 | 1,870 |
| Twinbee Portable (2007) | 19,875 | 22 |
| TwinBee RPG (1998) | 89,227 | 50 |
| TwinBee Taisen Puzzle-Dama (1994) | 50,929 | 35 |
| TwinBee Yahho! (1995) | 530,922 | 206 |
| TwinBlok (1996) | 305 | 6 |
| TwinCop (2019) | 13,744 | 23 |
| TwinGrip (2026) | 475 | 1 |
| Twinity (2008) | 346,498 | 8 |
| Twinkle Hunter (2023) | 6,416 | 14 |
| Twinkle Star Sprites (1996) | 1,443,024 | 2,636 |
| Twinkle Star Sprites: La Petite Princesse (2005) | 85,916 | 120 |
| Twinkle Tale (1992) | 552,365 | 390 |
| Twinkleby (2025) | 43 | 2 |
| The Twins (2020) | 0 | 0 |
| Twins & Dreams (2025) | 0 | 0 |
| Twins Edge : Back and Forth (2022) | 1,547 | 2 |
| Twins of the Pasture (2017) | 1,241,282 | 23 |
| Twinsen's Little Big Adventure 2 Classic (2015) | 3,576 | 46 |
| Twinsen's Little Big Adventure Classic (2015) | 2,236 | 59 |
| Twintail on the Battlefield (2016) | 68,242 | 12 |
| Twinworld (1989) | 80,353 | 330 |
| Twinxoid (2005) | 1,110 | 4 |
| Twist of Destiny (2017) | 964,171 | 125 |
| Twisted Draw (2022) | 595 | 3 |
