| 1. |  Polygon | DEFCON scares me and science says it will scare you too | 4,356,401 | |
| 2. |  Sips | Yogscast Play Defcon - Part 1 - Everybody Tries | 674,681 | |
| 3. | Kaikaki | Defcon Official Soundtrack | 601,133 | |
| 4. |  Rimmy Downunder | The Great Betrayal - ICBM (8 Player Update) | 424,490 | Vlog |
| 5. | Sips | Yogscast Play Defcon - Part 2 - Everybody Dies | 401,161 | |
| 6. |  Axul's Channel | DEFCON - Аксал сражается в ЯДЕРНОЙ ВОЙНЕ | 256,916 | |
| 7. | Sybert | Massive 3v3 on DEFCON 6 - Generals Evolution | 199,935 | |
| 8. | Introversion Software | DEFCON Trailer | 165,392 | Preview |
| 9. | Drew Durnil | What if every continent used nukes until nothing was left? (DEFCON) | 154,005 | |
| 10. | GOG | DEFCON trailer | 148,179 | Preview |
| 11. | Introversion Software | DEFCON Trailer 2020 | 107,483 | Preview |
| 12. | MyTechnologyyy | Defcon Gameplay: Playing as Europe | 105,117 | |
| 13. |  Alex The Rambler! | This New Grand Strategy Game ICBM Will Ruin Friendships | 98,620 | |
| 14. | CptObviousKyle | How To Play- Defcon | 95,264 | Guide |
| 15. | Culveyhouse | How to Play DEFCON Demo Version (A Full 1v1 Game in 1080p HD) | 60,881 | |
| 16. | Waypoint | Playing DEFCON with a Nuclear Arms Expert | 56,391 | |
| 17. | Nookrium | ICBM - (World War Real-Time Strategy Game) | 56,016 | |
| 18. | CptObviousKyle | Defcon (Nuclear Warfare Simulator) | 54,897 | |
| 19. | Best War Games Channel | SIMULATOR OF NUCLEAR WAR! Tactical Strategy DEFCON! The game on the PC about the Apocalypse | 43,825 | |
| 20. | Volcom Astro | Defcon - Original Soundtrack | 42,765 | |
| 21. | Nookrium | ICBM - (World Destroying Real Time Strategy Game) | 39,410 | |
| 22. | CptObviousKyle | Defcon 3v3 (Multiplayer) | 34,637 | |
| 23. | G4U1Undertow | Let's Play DEFCON: Everybody Dies Part 1 | 33,699 | |
| 24. | BaTBaiLeyS | Stratégie Totale - Épisode Spécial 500 000 visionnements - 1/2 (DEFCON) | 28,709 | |
| 25. | andimalloutofgum | DEFCON - Merry Christmas - Winter Achievement | 26,430 | |
| 26. |  CaMaK | [Replay] Altis Life S04 Episode Bonus - Defcon 1 (Police) | 25,244 | |
| 27. | The Historical Gamer | ICBM - A New Game - Co-op Gameplay with TortugaPower - Part 1 | 23,148 | |
| 28. |  SmartWargames | Global Nuclear War Simulation - DEFCON | 22,357 | |
| 29. | MasterofRoflness | GLOBAL NUCLEAR GENOCIDE! Nuclear Warfare Real Time Strategy Game - Defcon Gameplay | 21,012 | |
| 30. | sophycz | Sophy.cz - Let's Play Česky - Defcon | 16,432 | |
| 31. | BaTBaiLeyS | Stratégie Totale - Épisode Spécial 500 000 visionnements - 2/2 (DEFCON) | 15,560 | |
| 32. | Culveyhouse | DEFCON: Everybody Dies 1v1 Multiplayer Match, EzioCroft vs. CulveyNuke | 14,818 | |
| 33. | Mitchell Godsend | ICBM - The Game DEFCON Players Have Been Waiting For | 14,708 | |
| 34. |  Fish who lives in the woods | Третья Мировая Война случилась! (DEFCON) | 14,145 | |
| 35. | TortugaPower | ICBM (PC game) | Coop Multiplayer w/ THG - 01 - Destroyer All-In | 13,553 | |
| 36. | GameSpot | DEFCON: Everybody Dies - Random Encounter | 12,975 | |
| 37. | MasterofRoflness | A Game that Lets me start WW3 and Nuke Everyone Defcon | 12,918 | |
| 38. | Shadowhawk | -01- Let's Play Defcon Multiplayer | 12,610 | Let's Play |
| 39. | Nookrium | First Strike: Final Hour - (Real Time Strategy Nuclear War Game) | 11,967 | |
| 40. | YixelGaming | Defcon Trailer | 11,536 | Preview |
| 41. | Dodge Them All | DEFCON: EVERYBODY DIES | 11,271 | |
| 42. | BaTBaiLeyS | ATTAQUE NUCLÉAIRE sur l'EUROPE - DEFCON | 10,232 | |
| 43. | Sybert | Explosive Super Weapon - DEFCON 6 - Generals Evolution | 10,229 | |
| 44. | SteamLog | DEFCON (EVERYBODY DIES TRAILER) | 10,061 | Preview |
| 45. | Axul's Channel | DEFCON - ЯДЕРНЫЙ БАНХАММЕР (стримим ТРЕТЬЮ МИРОВУЮ) | 9,631 | |
| 46. | Sheep | DEFCON gameplay PC - Guerra nuclear Rusia vs OTAN | 9,473 | |
| 47. | MasterofRoflness | Defcon Gameplay - World War Three Simulator | 9,383 | |
| 48. | Jdebruez987 | DEFCON | 5 Player Multiplayer Match - Gameplay | 9,244 | |
| 49. | Sybert | Burning Hot 2v2v2 on DEFCON 6 - Generals Evolution | 8,904 | |
| 50. | TEAMFORTRESS2MASTER | Steam Winter Achievement - DEFCON - Merry Christmas (www.steamcheeves.com) | 8,133 | |
| 51. | finalgirlrun | DEFCON East vs. West Nuclear War Timelapse | 7,735 | |
| 52. | The Historical Gamer | ICBM – First Impressions – Free Download (Steam Festival) – Part 1 | 7,321 | First Impressions |
| 53. | DoMiNaToR | 6 Player Nuclear FFA - Defcon 6 | Generals Evolution | 7,010 | |
| 54. | DoMiNaToR | Big 2v1 vs TikTok Streamer??? | Defcon FROST | 6,828 | |
| 55. | The Historical Gamer | ICBM - Out Now! - Eve of Destruction - Co-op with TortugaPower - Part 2 | 6,828 | |
| 56. | Shadowhawk | -03- Let's Play Defcon Multiplayer [Diplomacy Survivor] | 6,816 | Let's Play |
| 57. | Gardiner Bryant | OpenRCT2 | Open Source Gaming Showcase | 6,814 | |
| 58. | TortugaPower | ICBM (PC game) | Coop Multiplayer w/ THG - 02 - Road to Armageddon | 6,611 | |
| 59. | cncHD Archive | cncZH - cncHD Joins Free For All Game Defcon | 6,110 | |
| 60. | Really Slow Motion | Really Slow Motion & Giant Apes - Defcon (Atmospheric Dramatic Trailer Music) | 6,071 | |
| 61. | Atomaround | Defcon - Everybody Dies [B2] | 6,054 | |
| 62. | DoMiNaToR | 1v1v1v1v1 Defcon 6 | GLA | 5,746 | |
| 63. | Gameplay Twist | How To Install Defcon Mods | 5,240 | Tutorial |
| 64. |  CrazyBlackstoneNR1 | ЛУЧШИЕ СТРАТЕГИИ НА ПК 2020 / Симулятор Войны США против Россия! | 4,879 | |
| 65. | TortugaPower | ICBM (PC game) | Coop Multiplayer w/ THG - 03 - Mutual Destruction | 4,351 | |
| 66. | The Historical Gamer | ICBM – Nuclear War! – Free Download (Steam Festival) – Part 2 | 3,921 | |
| 67. | Luetin09 | DEFCON Everybody Dies | LT (Africa) vs Trev (SA) | 3,792 | |
| 68. | C-c-combo Breaker Live! | Клуб «Синий попугай» показывает Кузькину мать в DEFCON | 3,692 | |
| 69. |  Ace Of Spades | DEFCON: Everybody Dies - 4 A.I gameplay | 3,671 | |
| 70. | Real Strategy Gaming | Ra2 Defcon 6 Usa vs French Center Tactic | 3,470 | |
| 71. | PS1DemoMuseum | Wargames: Defcon 1 (Playable Demo) - Official UK Playstation Magazine 17 vol. 2 | 3,285 | Let's Play |
| 72. | Eric F | Defcon: Everybody Dies - Main Menu | 3,202 | |
| 73. | itrSIMPLE | Red Bull Madness | POWER HOUR | Defqon.1 Weekend Festival 2019 | Reaction | 3,143 | |
| 74. |  Oxillious | DEFCON - Nuclear War Simulator (Let's Try) | 2,972 | |
| 75. | The Historical Gamer | ICBM – Gameplay – Nuking Friends - Wolfpack345 – TortugaPower – Finnishjager – Part 2 | 2,916 | |
| 76. | Jdebruez987 | DEFCON Lets-play | Tutorial Basics Walkthrough | 2,913 | Walkthrough |
| 77. | Effing Controller | Effing Around in DEFCON with Tailmange! | 2,850 | |
| 78. | TheTricky511 | First Strike Final Hour - Nuke Everyone - Episode 1 (Weekend Wonder) | 2,657 | |
| 79. | MyTechnologyyy | Speed Defcon Gameplay: Playing as Asia | 2,602 | |
| 80. | Shadowhawk | -02- Let's Play Defcon Multiplayer | 2,542 | Let's Play |
| 81. | The Historical Gamer | New Game Announced! | ICBM: Escalation | 2,423 | |
| 82. | Games Trailers Channel | DEFCON Virtual Reality - Steam Game Trailer | 2,274 | Preview |
| 83. | Digital Tribe | Navalia Release Trailer | 2,262 | |
| 84. | Alex_D20 | ЯДЕРНА ВІЙНА РОCІЯ ПРОТИ США - МОЖЛИВО ВРЯТУВАТИ СВІТ? | DEFCON | 2,248 | |
| 85. | Mr Nobody in VR | DEFCON - Ukraine Nuclear War - Ai Escalation Simulation #2 - Russia China BLOC vs USA NATO - Sim#2 | 2,197 | |
| 86. |  Table | DEFCON - Everbody DIES | 2,178 | |
| 87. |  RB33z | Defcon: 1984 Timelapse 1 | 2,158 | |
| 88. | The Dice Tower | DEFCON Review - with Jeff Knapp | 2,095 | Review |
| 89. |  DARLING | مسابقه انلاین جنرال دو به سه نقشه دفکون | گیم خیلی چالشی و پر از نبرد | مسابقه با پول ده هزار | دفکن | 2,085 | |
| 90. | RB33z | Defcon: British-Soviet Cold War Timelapse | 1,953 | |
| 91. | Arthur Huynh | Defcon - Merry Christmas Achivement (Steam Gift Grab) | 1,827 | |
| 92. | GameplayReviewUK | DEFCON - Game Overview | 1,756 | |
| 93. | Sleepyjo2 | What Have We Done!? Defcon - Everybody Dies | 1,756 | Let's Play |
| 94. |  BrotherPedro | DEFCON - 萬聖節節目 | 1,581 | |
| 95. | Dad's Gaming Addiction | DGA Plays: DEFCON (Ep. 1 - Gameplay / Let's Play) | 1,559 | Let's Play |
| 96. | Marioo Zoldyck | Defcon gameplay HD | 1,548 | |
| 97. | Zombie Cheshire | Day 4, GothCon art for DefCon 2023 #gothartist #disabledartists #defcon #cybergoth #cyberpunkart | 1,516 | |
| 98. | Gameplay Twist | Defcon Genocide Today Mod, also using Deterrence Mod | 1,500 | |
| 99. | Luetin09 | Luetin plays Defcon | LT (europe) vs Trev (US) | 1,495 | |
| 100. | Gameplay Twist | Defcon PC Game Mods | 1,486 | |
