| 1. |  MrGreenYeti | 3:21:52:29 | Let's Play The Binding of Isaac - 25 - 'Scrapping' | 28:22 |
| 2. | Millbeeful | 1:16:42:57 | The Binding Of Isaac | SHAKE OFF THE RUST - Millbee's Playthrough Part 46 | 19:04 |
| 3. | MrAndersonLP | 1:06:43:44 | Let's Play The Binding of Isaac: New Save File (Gameplay/Walkthrough) [Part 5] | 33:19 |
| 4. | Masterath Gaming | 15:27:48 | Let's Play The Binding of Isaac part 47/47: Chained no More... | 14:16 |
| 5. | Kino_Plays | 9:21:46 | Kino-Plays: The Binding of Isaac - 13/10/21 - 2 | 1:02:32 |
| 6. | TheXploder | 5:15:11 | Let's Play, Binding Of Isaac: Wrath of the Lamb Part 12: One Eyed Lovin | 33:29 |
| 7. | Armerus | 4:56:08 | The Binding of Isaac - GamerArmerus Playthrough/Commentry - Episode w/e | 40:05 |
| 8. | MizuhoChan | 4:32:27 | Let's Play The Binding Of Isaac - Part 8 - Die Mom, Die! | 36:09 |
| 9. | YetiHype | 4:19:20 | Lets play The Binding of Isaac - Episode 14 - Redo | 34:38 |
| 10. | StupidlyEPIC | 3:28:48 | Prime Plays The Binding of Isaac - Episode 7 | 51:54 |
| 11. | Marly Games | 3:09:23 | Let's Play A Wizards Lizard | Episode 18 [My Best Run] | 40:32 |
| 12. | Steejo | 3:07:08 | 100%ing The Binding of Isaac With Steejo Episode 83 | 9:05 |
| 13. | Dommy1218 | 2:09:59 | Dommy1218 plays - WHY THE F*CK IS THERE SO MUCH LOADING!? | 20:01 |
| 14. | FlareBlitzed | 2:06:40 | Walking on a Star Unknown (RPG Maker) - Part 8 | Flare Let's Play | Yurika's Freedom | 1:00:25 |
| 15. | JDTSlash | 1:46:27 | Let's play: The binding of Isaac - Episode 1 (So close yet so far) | 1:46:27 |
| 16. | Mikehyphenplays | 1:31:35 | Back down the cellar: The Binding of Issac #17 | 16:36 |
| 17. | TrU3Ta1ent | 1:30:44 | Let's play The Binding of Isaac with hilarious commentary [part 1] FIRST RUN! | 1:30:44 |
| 18. | Atomic Brainbag | 1:28:29 | BINDING OF ISAAC - Funny Poop! | 16:23 |
| 19. | WhiteNinjaArt | 1:02:27 | The binding of isaac part3 continued full play through | 37:22 |
| 20. | Goth_Jester22 | 59:03 | The Binding Of Isaac Playthrough With Judas | 59:03 |
| 21. | TophuNugget | 54:10 | i'm a greedy rat | 54:10 |
| 22. | Dan Does | 54:01 | How to Make Lots of The Binding of Isaac Sculpts! | 5:57 |
| 23. | RobinLSL | 51:32 | Let's Play The Binding of Isaac - 1 - Discovery | 51:32 |
| 24. | Sector Alpha Gaming | 49:24 | The Binding of Isaac - #2 'Let's Kill Mom Mission!' | 27:44 |
| 25. | Eurogamer | 48:55 | Let's Play The Binding of Isaac - Late to the Party | 48:55 |
| 26. | Mr. Nutt | 44:17 | Let's Play: The Binding of Isaac | 21:29 |
| 27. | Elanip | 44:02 | The Binding of Isaac: Lets Play Episode. 3 - Big Worm Had Me For Lunch | 13:39 |
| 28. | ParkyGames | 42:11 | Parky's Shorts - Wrath of The Lamb - Part 1 - Let's Do This! | 13:20 |
| 29. | falpatrick | 34:10 | DISAPPOINTMENT - Binding of Isaac Playthrough Part 2 | 11:24 |
| 30. | AtomTheCat | 34:00 | Atom plays the binding of Isaac p3 (Hello darkness my good pal) | 12:45 |
| 31. | JustRed | 33:55 | The Binding of Isaac | Wrath of the Lamb Playthrough | 33:55 |
| 32. | ackieforest | 30:39 | Let's Play The Binding of Isaac part 666 "Isaac starts a gang!" | 30:39 |
| 33. | JoshFTL | 30:38 | Binding of Isaac head2head with Eclipse the Gamer! | 30:38 |
| 34. | FBDC | 30:23 | FBDC Plays - The Binding of Isaac | 30:23 |
| 35. | Tomzilla | 27:24 | Quick Feature - Let it die Part FINAL | 27:24 |
| 36. | Jaru | 25:37 | I HATE MONSTRO!:The Binding of Isaac Let's Play w/Jaru Part 2 | 11:07 |
| 37. | Makenshi | 23:18 | Let's Play: Bind of Issac E1 - Failure is considered an option | 23:18 |
| 38. | Storpey | 23:09 | Steve plays The Binding of Isaac (Storpey's Steam Stuff) | 23:09 |
| 39. | PyroJoe | 23:09 | PyroJoe Plays: The Binding Of Isaac! #2 | 23:09 |
| 40. | OfficialNerdCubed | 20:04 | Nerd³ Plays... The Binding of Isaac | 20:04 |
| 41. | CNPGames | 12:25 | CNPGames Plays - Binding Of Isaac - Episode 14 - Im back! | 12:25 |
| 42. | The CaffCast | 11:17 | CaffCast Plays - The Binding Of Isaac - Wrath Of The Lamb | 11:17 |
| 43. | MrUnderdoglx | 9:30 | The Binding of Isaac Lets Play | 9:30 |
| 44. | PieDragonPS | 9:12 | The Binding of Isaac [Glitch] - 9 Lives = Lots of Boss Items | 3:36 |
| 45. | Chawesy | 9:00 | THE CAT MURDERED MY MOM | Cat Evolution : Alpaca Zombie! | Gameplay, Reaction | 9:00 |
| 46. | Evanz111 | 8:30 | The Random Commentaries: Binding of Isaac | 8:30 |
| 47. | Nick Ball | 7:48 | Nick Ball Plays - Binding Of Isaac - Episode 1 | 7:48 |
| 48. | Green Man Gaming | 5:29 | Green Team Presents | Binding of Isaac | 5:29 |
| 49. | IdioticUlt1mara | 4:01 | Idiotically Reviewing Fallen Angel | 4:01 |
| 50. | AlpaxLP | 2:51 | Channel Update 1 - Isaac, CK2, New LP | 2:51 |
| 51. | Jimbo Spike | 2:43 | The Binding Of Isaac - Lotsa Bombs (Loud!) | 2:43 |
