| 1. |  WebmistressL | 10:01:37:29 | L Plays The Binding of Isaac Afterbirth+ - 096 - Panic | 59:09 |
| 2. | MrAndersonLP | 7:11:22:04 | Let's Play The Binding of Isaac: Afterbirth Plus (The Forgotten Update) [Part 6] | 54:08 |
| 3. | Commodore Grayum | 7:08:51:07 | THE LOST ENTERS HARD MODE | The Binding of Isaac: Antibirth | Ep 152 | Rebirth mod/modpack | 1:13:34 |
| 4. | Flik's Gaming Stuff | 4:09:53:36 | Flik Plays The Binding of Isaac Afterbirth+ | #136 | "Greed Done" | 55:55 |
| 5. | Millbeeful | 4:01:27:31 | The Big Risk Plays | The Binding of Isaac: Repentance | #6 | 56:50 |
| 6. | Aleavaye | 2:18:13:30 | Runs 113 - 115 - Ascent To 100% - TBOI: Repentance Stream Playthrough | 31:42 |
| 7. | YetiHype | 1:07:51:07 | The Binding of Isaac: Afterbirth - Let's Play - Episode 36 [Finale] | 32:18 |
| 8. | Neo Rambler | 1:02:45:47 | Let's Play The Binding Of Isaac Afterbirth (PC): Part 22 | 59:24 |
| 9. | Game N Chat , Lill | 23:05:53 | 🔴Binding of Isaac, Repentance #32 Lill 🤗 Trying Tainted Bethany for the First Time! | 3:25:18 |
| 10. | Masterath Gaming | 22:43:46 | Let's Play The Binding of Isaac: Repentance part 73/73: To the Final Promised Land! | 14:33 |
| 11. | Crashpunk | 19:56:31 | Wariopunk Plays: The Binding of Isaac: Afterbirth+ #3 - Delirium! | 14:42 |
| 12. | Bwnci | 18:44:44 | The Binding of Isaac: Rebirth - Loud Play | Part 38 - Digwig | 47:57 |
| 13. | Jack | 18:22:51 | Isaac Delirium Kill - Isaac Afterbirth Plus Gameplay - Let's Play: Part 18 | 34:55 |
| 14. | Steejo | 16:17:26 | Let's Play Binding of Isaac Afterbirth Part 33 | 23:14 |
| 15. | Captain SnakeCharmer | 12:34:20 | Not So Prideful | The Captain Plays: The Binding of Isaac: Afterbirth+ [Part 5] | 39:28 |
| 16. | caramida9 | 12:00:56 | NEW UPDATE, SAME ME Let's play: The Binding of Isaac - REPENTANCE -#18 | 25:33 |
| 17. | MrGreenYeti | 7:55:38 | Let's Play The Binding of Isaac: Rebirth - 12 - 'Sweet Suffering' | 32:34 |
| 18. | Orbital Potato | 7:01:47 | Binding of Isaac: Rebirth x2 - Stellar Plays! - #4 | 41:38 |
| 19. | MadGod | 5:55:26 | Madgod Plays - The Binding of Isaac: Afterbirth Episode 28 | 16:36 |
| 20. | Mr Dark Fox | 5:43:28 | Foxxy plays Binding of Isaac (Test stream) | 1:14:29 |
| 21. | Sector Alpha Gaming | 5:42:06 | Droidxnd plays Binding of Issac Afterbirth + | 2:13:41 |
| 22. | Marly Games | 5:35:11 | Marly Plays The Binding of Isaac Rebirth - Episode 2 - Technological Pyromancer | 23:58 |
| 23. | TVR | 5:25:18 | The House in Fata Morgana / Chapter 3 (PS Vita Gameplay) | 5:25:18 |
| 24. | JohnTMorton | 5:25:16 | Nostalgamer Local COOP Lets Play The Binding Of Isaac Rebirth With SmokinHadz Live On PS4 Part Two | 2:03:07 |
| 25. | Arkonauts | 4:59:59 | The Binding of Isaac: Afterbirth+ - PICKING PLAYS | 18:46 |
| 26. | Silver Gaming Network | 4:29:54 | Oni - Anniversary Edition - Part 1 (Silver Gaming Network) | 2:56:37 |
| 27. | Mr Samuel Streamer | 2:50:20 | Keys, Bombs, and Hearts + Moving Channels! | Binding of Isaac: Repentance #4 | 34:43 |
| 28. | That Ifrit Guy | 2:38:15 | Let's Play Binding of Issac: Rebirth - 03 - The Heart | 40:45 |
| 29. | Bam654328 | 2:32:16 | The Binding Of Isaac Rebirth: Farming for money Stream 3 (to help with the lost) | 2:32:16 |
| 30. | Yewb | 2:24:24 | Yewb Plays: The Binding of Isaac Afterbirth+! [Episode 3: Twitch VoD 2] | 47:56 |
| 31. | Mikehyphenplays | 2:14:37 | Sony e3 2017 imperetions | 10:09 |
| 32. | My Cinnamon Phoe | 2:07:35 | Halloween Special: Let's Play The Binding of Isaac Afterbirth! | 47:44 |
| 33. | Tangociss | 2:04:47 | Tangociss Plays! Rebirth! Episode 7! FLY ARMY UNITE! | 26:03 |
| 34. | Memory Card Full | 1:31:01 | Memory Card full Plays The Binding of Isaac #TheBindingofisaac #livestream | 1:31:01 |
| 35. | apqLIVE | 1:24:59 | It's finally time for HARD MODE! (send help pls) | The Binding of Isaac: Repentance | 1:24:59 |
| 36. | Andolono | 1:24:05 | Terrible Plays - The Binding of Isaac: Repentance - from Zero to Hero - Part 7 | 34:08 |
| 37. | Alex The Anteater | 1:18:58 | The Binding Of Isaac Rebirth - Let's Play #2 | Lord of the Flies | 46:34 |
| 38. | Edit:Ed | 1:18:52 | Let's Play The Binding Of Isaac Afterbirth: (Episode 5) - THIS BASEMENT SHALL BE YOUR TOMB | 17:51 |
| 39. | Unofficial Nerdcubed Live! - Livestream Archive | 1:15:36 | Nerd³ Plays Isaac At 5am - Binding of Isaac Afterbirth+ - 18th September 2017 | 1:15:36 |
| 40. | AlpaxLP | 1:15:03 | Let's Play The Binding of Isaac: Rebirth - Part 2 - Eve'n Odds | 48:31 |
| 41. | Luna Bold, the Full Bold Streams | 1:06:34 | Kobold Plays Binding of Isaac - Repentance: Bethany Run! | 21:20 |
| 42. | MegaGWolf | 57:45 | Alphabirth | Binding of Isaac Mod | 24:26 |
| 43. | The Wandering Inn | 55:15 | Doodle Plays - The Binding of Isaac : Rebirth Part 2 | 27:44 |
| 44. | ScottishGeeks | 55:14 | Time to play | The Binding of Isaac Afterbirth Gameplay | 55:14 |
| 45. | TheRev Plays Games | 45:35 | Let's play The Binding of Isaac: Rebirth | 45:35 |
| 46. | Stylosa | 45:10 | The Binding of Isaac: Rebirth Co-op - PlayStation 4 Gameplay - Baby Ghost! | 15:17 |
| 47. | BehemothEmperor | 44:24 | Lets Play The Binding of Isaac: Rebirth - Escaping The Womb | 44:24 |
| 48. | Miss Meggiecat | 43:00 | "Army of One" - Let's Play: The Binding of Isaac Afterbirth | 11:09 |
| 49. | PieDragonPS | 41:18 | The Binding of Isaac: Rebirth [Glitch] - Speed of Betrayal | 0:33 |
| 50. | OwlTowel | 36:30 | [OwlPlays] - The Binding of Isaac: Rebirth (Again) | 8:11 |
| 51. | Gemini Games | 36:17 | Gemini plays The Binding of Isaac | 36:17 |
| 52. | Shrooboid313 | 35:15 | The Binding of Isaac Afterbirth+ AZAZEL CLUTCH PLAYS | 35:15 |
| 53. | Randomise User: The Best Indie Games | 35:11 | BINDING OF ISAAC REBIRTH: Hats off to Halloween 2018! | Indie Classics | 35:11 |
| 54. | Pedguin | 32:26 | Afterbirth Seed: Mage Playthrough | 32:26 |
| 55. | Snowy Duffield | 31:04 | Snowy Plays: The Binding of Isaac: Afterbirth + | 16:23 |
| 56. | Mr. Nutt | 30:35 | Let's Play Mini: The Binding of Isaac: Rebirth | 30:35 |
| 57. | AHF Best Gaming | 29:35 | The grand finale! | Binding of Isaac: Repentance - Ep. 06 | PS5 Gameplay | 29:35 |
| 58. | Alpaka Whacker | 29:34 | The Binding Of Isaac Rebirth - Alpaka Takes A Gander | 29:34 |
| 59. | WaterMelonLord | 29:18 | A Noob Plays The Binding Of Issac:Rebirth | 28:32 |
| 60. | JHIZZUM | 27:27 | Pro elden ring player plays Isaac | 27:27 |
| 61. | FlareBlitzed | 26:48 | DON'T YOU ZAP ME! | Abyss (RPG Maker Horror) - Part 2 | Flare Let's Play | 26:48 |
| 62. | Iamspuddicus | 26:30 | Road to Repentance Binding of Isaac Lets play Episode #1 - Merp Derp | 26:30 |
| 63. | NoodleHouse | 25:23 | Mystery Monday #15 | Binding of Isaac | 25:23 |
| 64. | OfficialNerdCubed | 25:22 | Nerd³ Plays... The Binding of Isaac - Afterbirth+ | 25:22 |
| 65. | AK1NG09 Gaming | 24:23 | The Binding of Isaac Rebirth || Gamplay playthrough part 1 || isaac,s Downfall [PC] | 24:23 |
| 66. | NXN Arcade | 23:43 | Let's Play the Binding of Isaac: Afterbirth | 23:43 |
| 67. | Wilsonator | 23:08 | Wilsonator Plays: The Binding of Isaac - Rebirth | 23:08 |
| 68. | shirlierox | 21:43 | the binding of isaac:rebirth gameplay - PS4 - Let's play - Episode 1 Reborn | 21:43 |
| 69. | RedGamingTech | 20:50 | Playstation Now | Sony Reveals Unlimited Subscription Option - Dat Price Tag Doe | 5:00 |
| 70. | JoshFTL | 20:28 | Alpha Watch - Anodyne | 20:28 |
| 71. | LumeVODs | 20:05 | The Binding Of Isaac - Beginnings - Part 1 | 20:05 |
| 72. | The_TimeTwister | 18:23 | Let's Play: The Binding of Isaac Rebirth | 18:23 |
| 73. | acidonia150 | 18:03 | Random Wednesday's Episode 1 | 18:03 |
| 74. | Frisky Carrot | 14:29 | Frisky Carrot Plays... The Binding Of Isaac: Rebirth | 14:29 |
| 75. | Rhys Da King VR | 12:22 | Let's play The Binding OF Isaac PS4 W/Crazy old Johnny | 12:22 |
| 76. | TearofGrace | 12:02 | WITCHER 3/GERALT MOD (a whole new playstyle) | The Binding of Isaac: AFTERBIRTH PLUS | 12:02 |
| 77. | 2 old 4 gaming | 8:04 | Binding of Isaac PSVita Physical Copy Discovered and History of Nicalis PS Vita Physical Releases | 8:04 |
| 78. | Evanz111 | 6:30 | evunz plays binding of isaac rebirth | 6:30 |
| 79. | URBAN GAMEPLAY | 5:05 | Best Upcoming Games Releasing in July 2017 Nintendo Switch, Xbox One, PC, Playstation 4 | 5:05 |
| 80. | 100%Jim | 4:01 | SPIDER BUTT - Kate plays Binding of Isaac | 4:01 |
| 81. | Hanternos | 0:33 | Channel Update - Help required! | 0:33 |
