| Eschalon: Book II (2010) | 331,363 | 344 |
| Eschalon: Book III (2014) | 177,370 | 146 |
| Eschaton (2022) | 37,663 | 41 |
| Eschatos (2011) | 635,187 | 643 |
| Escort Alia (2020) | 200 | 3 |
| Escortina Life! (2024) | 39,690 | 1 |
| ESEA (2016) | 5,312 | 2 |
| Esh's Aurunmilla (1984) | 60,293 | 34 |
| Eskimo Bob: Starring Alfonzo (2017) | 649 | 5 |
| Esophaguys (2023) | 66,751 | 54 |
| Esoteric Ebb (2026) | 353,888 | 262 |
| Esoterica: Hollow Earth (2013) | 55,072 | 67 |
| Esoterika (2024) | 0 | 0 |
| Esothe (2025) | 3,503 | 18 |
| ESP Ra.De. (1998) | 811,769 | 976 |
| ESP Ra.De. Psi (2019) | 104,871 | 51 |
| Esper (2015) | 1,355,248 | 282 |
| Esper - Make You Live Again (2019) | 129 | 11 |
| Esper 2 (2015) | 115,602 | 43 |
| Esper Boukentai (1987) | 5,365 | 4 |
| Esper Dream (1987) | 497,594 | 176 |
| Esper Dream 2: Aratanaru Tatakai (1992) | 158,368 | 98 |
| Esperia ~ Uprising of the Scarlet Witch (2023) | 7,006 | 36 |
| Espgaluda (2003) | 692,432 | 674 |
| Espgaluda II (2005) | 2,350,073 | 1,033 |
| Espionage (1988) | 1,593,340 | 269 |
| ESPIONAGE: Mafia Evolved (2022) | 10,667 | 54 |
| Espire 1: VR Operative (2019) | 3,605,247 | 892 |
| Espirito Delusion (2025) | 0 | 0 |
| ESPN Baseball Tonight (1994) | 204,033 | 162 |
| ESPN College Hoops (2003) | 40,709 | 88 |
| ESPN College Hoops 2K5 (2004) | 144,788 | 333 |
| ESPN Extreme Games (1995) | 652,878 | 335 |
| ESPN Final Round Golf 2002 (2001) | 15,786 | 43 |
| ESPN Great Outdoor Games: Bass 2002 (2001) | 7,936 | 11 |
| ESPN International Winter Sports 2002 (2002) | 83,129 | 155 |
| ESPN Major League Baseball (2004) | 53,772 | 150 |
| ESPN MLS ExtraTime (2001) | 77,516 | 68 |
| ESPN MLS ExtraTime 2002 (2002) | 52,856 | 60 |
| ESPN MLS GameNight (2000) | 124,832 | 201 |
| ESPN National Hockey Night (1994) | 219,659 | 155 |
| ESPN National Hockey Night (2001) | 16,898 | 24 |
| ESPN NBA 2K5 (2004) | 1,235,366 | 914 |
| ESPN NBA 2Night (2000) | 48,172 | 137 |
| ESPN NBA 2Night 2002 (2002) | 58,845 | 176 |
| ESPN NBA Basketball (2003) | 473,696 | 571 |
| ESPN NBA Hangtime '95 (1994) | 9,054 | 58 |
| ESPN NFL 2K5 (2004) | 13,003,450 | 5,552 |
| ESPN NFL Football (2003) | 304,540 | 600 |
| ESPN NFL Primetime 2002 (2001) | 25,802 | 112 |
| ESPN NHL 2K5 (2004) | 358,788 | 494 |
| ESPN NHL Hockey (2003) | 111,316 | 133 |
| ESPN SpeedWorld (1994) | 28,711 | 91 |
| ESPN Sunday Night NFL (1994) | 51,401 | 143 |
| ESPN Winter X-Games Snowboarding (2000) | 42,587 | 50 |
| ESPN Winter X-Games Snowboarding 2002 (2002) | 34,880 | 55 |
| ESPN X Games Skateboarding (2001) | 344,393 | 79 |
| ESport Manager (2018) | 726,716 | 243 |
| Esports Godfather (2024) | 33 | 1 |
| Esports History (2024) | 2,994,049 | 222 |
| eSports Legend (2018) | 16,814,605 | 357 |
| Esports Life Tycoon (2019) | 6,243,751 | 504 |
| Espresso For The Demon (2023) | 459 | 8 |
| Espresso Tycoon (2023) | 9,936,111 | 1,350 |
| Essays on Empathy (2021) | 205,631 | 72 |
| Essence Hunters (2025) | 0 | 0 |
| Essence Of The Tjikko (2022) | 0 | 0 |
| The Essence Reaper Ritual (2020) | 3,237 | 4 |
| Essential Power (2023) | 478 | 11 |
| Essential Sudoku DS (2006) | 682 | 6 |
| Essex (1985) | 485,008 | 86 |
| Estate Agent Simulator (2023) | 14,724,747 | 1,841 |
| Esteem - The little wolf saga (2025) | 1,991 | 16 |
| Estella's Nightmare: Sealed Space and a Succubus's Curse (2022) | 139,423 | 14 |
| Estellium Legends (2019) | 3,394 | 4 |
