| Endure The Swarm (2023) | 446 | 6 |
| Endurium (2020) | 122 | 3 |
| Enduro (1983) | 8,038,597 | 875 |
| Enduro Racer (1986) | 1,664,464 | 1,150 |
| EndWar (2008) | 1,319,866 | 657 |
| Endzone 2 (2024) | 1,466,751 | 857 |
| Endzone: A World Apart (2020) | 24,912,955 | 8,421 |
| Enelia: Dawn of Madness (2024) | 9,267 | 31 |
| The Enemy Approached The Walls (2022) | 144 | 2 |
| Enemy Engaged 2 (2007) | 24,274 | 19 |
| Enemy Engaged: Apache/Havoc (1998) | 394,557 | 18 |
| Enemy Engaged: RAH-66 Comanche vs. KA-52 Hokum (2000) | 71,871 | 55 |
| Enemy Front (2014) | 17,105,601 | 6,510 |
| Enemy Infestation (1998) | 79,837 | 174 |
| Enemy Inside (2024) | 0 | 0 |
| Enemy Nations (1997) | 48,297 | 14 |
| Enemy on Board (2020) | 13,517,125 | 291 |
| Enemy on the tail! (2024) | 25 | 2 |
| Enemy Remains (2022) | 12,155 | 29 |
| Enemy Strike (2013) | 184,265 | 92 |
| Enemy Territory: Quake Wars (2007) | 3,736,784 | 1,540 |
| Enemy Zero (1996) | 2,492,806 | 480 |
| Ener-G Gym Rockets (2008) | 594 | 6 |
| Energy (1989) | 427,595 | 166 |
| Energy Airforce Aim Strike! (2003) | 132,655 | 221 |
| Energy Balance (2015) | 75,149 | 68 |
| Energy Breaker (1996) | 480,145 | 594 |
| Energy Collector (2023) | 75,024 | 28 |
| Energy Cycle (2016) | 491,371 | 500 |
| Energy Fighters (2024) | 11,444 | 12 |
| ENERGY HEIST (2023) | 315 | 11 |
| Energy Hook (2016) | 462,550 | 47 |
| Energy Invasion (2018) | 225,074 | 131 |
| Enfora Star (2025) | 0 | 0 |
| Engaging Destiny (2023) | 3,613 | 4 |
| Engare (2017) | 7,803,368 | 129 |
| Engine Evolution 2021 (2022) | 41,384 | 68 |
| Engine Evolution 2022 (2023) | 47,899 | 92 |
| Engine Evolution 2023 (2023) | 21,728 | 53 |
| Engineer Alpha (2021) | 1,815 | 23 |
| Engineered To Purpose (2023) | 1,324 | 35 |
| England Championship Special (1991) | 1,310 | 9 |
| English Country Tune (2011) | 260,958 | 106 |
| English of the Dead (2008) | 109,484 | 61 |
| English Training: Have Fun Improving Your Skills! (2006) | 150,702 | 36 |
| Engram (2019) | 602,780 | 105 |
| Engraven (2024) | 1,092 | 1 |
| Enigma (1998) | 169,456 | 56 |
| Enigma (2007) | 707,705 | 149 |
| The Enigma Cases (2026) | 74,689 | 46 |
| Enigma Code (2023) | 20 | 1 |
| Enigma Force (1985) | 50,367 | 29 |
| Enigma Of Forest (2024) | 13 | 1 |
| Enigma Quest (2023) | 17,550 | 20 |
| Enigma: Rising Tide (2003) | 253,148 | 35 |
| Enigmarble (2024) | 0 | 0 |
| Enigmatic Worlds (2024) | 63,133 | 68 |
| Enigmatis 2: The Mists of Ravenwood (2013) | 6,801,806 | 2,088 |
| Enigmatis 3: The Shadow of Karkhala (2016) | 825,560 | 1,250 |
| Enigmatis: The Ghosts of Maple Creek (2011) | 1,733,953 | 2,372 |
| Enigmo (2003) | 506,889 | 19 |
| Eniko: Ghosts Of Grace (2023) | 10,483 | 4 |
| Enionax (2022) | 106 | 8 |
| Enishia and the Binding Brand (2024) | 1,000 | 9 |
| The Enjenir (2023) | 3,550,328 | 447 |
| ENKI (2015) | 1,761,243 | 223 |
| Enlightenus (2009) | 28,487 | 25 |
| Enlightenus: The Timeless Tower (2010) | 25,236 | 37 |
| Enlisted (2021) | 336,745,166 | 93,316 |
| Enlysia (2017) | 1,949 | 4 |
| Ennichi no Tatsujin (2006) | 2,279,802 | 26 |
| Ennuigi (2015) | 14,131 | 8 |
| Enoch: Underground (2018) | 0 | 0 |
| Enola (2014) | 12,437,526 | 533 |
| Enotria: The Last Song (2024) | 4,722,199 | 3,898 |
