| Enough with the Witch (2025) | 304 | 1 |
| Ensemble Girls! (2012) | 24,261 | 41 |
| Ensemble Stars (2015) | 15,889,407 | 7,824 |
| Enshrouded (2024) | 78,853,457 | 46,701 |
| Enshrouded World: Home Truths (2018) | 737 | 5 |
| The Ensign (2014) | 50,415 | 22 |
| Enslaved: Odyssey to the West (2010) | 19,054,980 | 11,515 |
| Enspell (2024) | 25,280 | 8 |
| Entanglement (2010) | 5,188,000 | 158 |
| Entasy Online (2022) | 952 | 8 |
| The Entente Gold (2014) | 27,703 | 68 |
| The Entente: Battlefields World War I (2003) | 7,869 | 8 |
| Enter Digiton: Heart of Corruption (2020) | 24,286 | 87 |
| Enter the Chronosphere (2026) | 101,970 | 75 |
| Enter The Cyberjungle (2023) | 0 | 0 |
| Enter the Dominatrix (2013) | 21,253 | 56 |
| Enter the Gun Dungeon (2019) | 2,673 | 56 |
| Enter the Gungeon (2016) | 310,687,212 | 76,474 |
| Enter the Gungeon: House of the Gundead (2020) | 769,292 | 52 |
| Enter The Lost Chamber (2024) | 6,875 | 3 |
| Enter the Matrix (2003) | 25,758,738 | 4,110 |
| Enter the Nemesis: Blood Portal (2026) | 0 | 0 |
| Enthralled (2024) | 5,893 | 10 |
| Enthusia Professional Racing (2005) | 3,222,335 | 2,092 |
| Entities (2024) | 1,453,508 | 275 |
| The Entity (2018) | 254,880,353 | 4,364 |
| Entity Researchers (2022) | 11,520 | 15 |
| The Entity Within (2023) | 22,876 | 10 |
| Entity: The Black Day (2023) | 1,424,889 | 199 |
| Entogious (2023) | 46,233 | 5 |
| Entombed (1982) | 469,539 | 40 |
| Entombed (1985) | 43,233 | 13 |
| Entomophobia (2022) | 45,417 | 23 |
| Entomorph: Plague of the Darkfall (1995) | 56,586 | 83 |
| Entrepreneurial tycoon (2023) | 0 | 0 |
| Entropia Universe (2003) | 23,057,686 | 22,962 |
| Entropic Float: This World Will Decay And Disappear (2022) | 44 | 2 |
| Entropic Shop VR (2018) | 0 | 0 |
| Entropy (2013) | 1,076,277 | 504 |
| Entropy : Zero (2017) | 3,587,925 | 3,159 |
| The Entropy Centre (2022) | 5,558,788 | 5,171 |
| Entropy Survivors (2024) | 334,007 | 399 |
| Entwined (2014) | 1,742,419 | 661 |
| Entwined Time (2024) | 23,459 | 1 |
| Entwined: Strings of Deception (2017) | 0 | 0 |
| Entwined: The Perfect Murder (2018) | 61 | 1 |
| Enviro-Bear 2000: Operation: Hibernation (2009) | 373,226 | 25 |
| Enviro-Bear 2010 (2009) | 210,329 | 33 |
| Environmental Station Alpha (2015) | 1,243,258 | 1,317 |
| Envyus (2024) | 321,270 | 29 |
| Enworden (2022) | 126 | 4 |
| ENYO Arcade (2015) | 2,763 | 14 |
| Enypnion Redreamed (2023) | 45 | 3 |
| ENZBOTS (2019) | 360 | 4 |
| Enzio-Ware (2025) | 0 | 0 |
| EOE: Eve of Extinction (2002) | 237,293 | 293 |
| Eol-ui Moheom (1995) | 4,278 | 8 |
| Eon Altar (2016) | 57,948 | 54 |
| EON Fighter (2022) | 8,206 | 45 |
| Eon of the Green (2023) | 47 | 3 |
| EON Trooper (2024) | 1,091 | 8 |
| Epanalepsis (2015) | 2,694 | 16 |
| Ephemeral -Fantasy on Dark- (2018) | 811,170 | 214 |
| Ephemeral Fantasia (2000) | 149,945 | 487 |
| Ephemeral Tale (2020) | 7,357 | 64 |
| Epic (1992) | 5,862,893 | 264 |
| Epic 7 (2011) | 55,836 | 71 |
| Epic Adventures: Cursed Onboard (2012) | 20,263 | 29 |
| Epic Adventures: Cursed Onboard (2019) | 0 | 0 |
| Epic Adventures: La Jangada (2019) | 0 | 0 |
| Epic Arena (2015) | 185,425 | 77 |
| Epic Astro Story (2011) | 53,885 | 108 |
| Epic Auto Towers (2024) | 1,947,806 | 656 |
| Epic Battle Fantasy 2 (2009) | 1,081,404 | 334 |
| Epic Battle Fantasy 3 (2010) | 5,551,246 | 2,228 |
