| Eternam (1992) | 820,283 | 79 |
| EternaMine (2023) | 0 | 0 |
| Eternia: Pet Whisperer (2021) | 1,202 | 4 |
| Eternights (2023) | 6,274,252 | 8,404 |
| Eternity Guards (2022) | 702 | 4 |
| Eternity's Child (2008) | 31,288 | 16 |
| Eternity: The Last Unicorn (2019) | 1,053,030 | 675 |
| Eternium (2021) | 3,852,842 | 2,469 |
| Eternower (2020) | 1,470 | 1 |
| Eternum Ex (2018) | 38,969 | 87 |
| Ethan: Meteor Hunter (2014) | 710,954 | 398 |
| Ether Awakening (2017) | 0 | 0 |
| Ether Loop (2020) | 939,610 | 84 |
| Ether One (2014) | 2,199,691 | 1,604 |
| Ether Saga Odyssey (2009) | 1,495,017 | 154 |
| Ether Vapor Remaster (2011) | 40,694 | 147 |
| Etherborn (2019) | 625,936 | 482 |
| The Ethereal Dream (2025) | 20 | 6 |
| Ethereal Enigma (2023) | 60,061 | 407 |
| Ethereal Fracture (2025) | 22 | 2 |
| Ethereal Legends (2017) | 32,667 | 12 |
| Ethereal Sunder (2025) | 0 | 0 |
| EtheriiA - Travelogue (2026) | 0 | 0 |
| Etherlords (2001) | 297,977 | 348 |
| Etherlords II (2003) | 1,020,018 | 976 |
| Ethics Empire (2026) | 0 | 0 |
| Ethnic Cleansing (2002) | 599,657 | 33 |
| ETO (2024) | 5,303,934 | 180 |
| Etrian Mystery Dungeon (2015) | 2,726,330 | 463 |
| Etrian Mystery Dungeon 2 (2017) | 16,941 | 21 |
| Etrian Odyssey (2007) | 9,191,173 | 9,639 |
| Etrian Odyssey 2 Untold: The Fafnir Knight (2014) | 6,103,202 | 1,572 |
| Etrian Odyssey II (2008) | 2,861,922 | 2,604 |
| Etrian Odyssey III (2010) | 6,656,261 | 4,879 |
| Etrian Odyssey IV (2012) | 7,245,826 | 1,251 |
| Etrian Odyssey Nexus (2018) | 4,690,276 | 1,719 |
| Etrian Odyssey Untold: The Millennium Girl (2013) | 5,656,289 | 1,387 |
| Etrian Odyssey V (2016) | 4,644,977 | 1,467 |
| Etrom: The Astral Essence (2006) | 6,187 | 30 |
| Ettrian - The Elf Prince (2023) | 2,825 | 43 |
| Euchre (2002) | 23,781 | 22 |
| Euclid Valley (2024) | 0 | 0 |
| Euclid's Inferno (2024) | 129 | 1 |
| Euclidean (2015) | 509,339 | 162 |
| Euclidean Escape (2023) | 65 | 2 |
| Euclyca (2021) | 1,081 | 3 |
| Eudemons M (2020) | 31,141 | 9 |
| Eudemons Online (2006) | 653,335 | 311 |
| Eufloria (2009) | 563,317 | 401 |
| Eugene's Dream: The Daily Ins And Outs Of A Sane Robot In An Insane World (2020) | 0 | 0 |
| Euijeok: Im Kkeokjeong (1994) | 0 | 0 |
| Euphionia: The Tree Spirit's Curse (2025) | 0 | 0 |
| Eureka Seven Vol. 1: The New Wave (2005) | 216,719 | 198 |
| Eureka Seven Vol. 2: The New Vision (2006) | 292,394 | 190 |
| Eureka! (1984) | 18,431,585 | 792 |
| Euro Fishing (2015) | 7,919,133 | 1,186 |
| Euro Rally Champion (2004) | 28,378 | 44 |
| Euro Truck Simulator (2008) | 156,289,273 | 76,760 |
| Euro Truck Simulator 2 (2012) | 8,824,149,165 | 1,496,147 |
| Eurobi Racing (2018) | 51 | 2 |
| Eurofighter Typhoon (2001) | 1,261,600 | 411 |
| Europa 1400: The Guild (2002) | 1,346,597 | 449 |
| Europa Universalis (2000) | 65,963,475 | 24,009 |
| Europa Universalis II (2001) | 520,913 | 263 |
| Europa Universalis III (2007) | 11,666,938 | 6,647 |
| Europa Universalis IV (2013) | 1,112,086,337 | 282,972 |
| Europa Universalis V (2025) | 24,931,976 | 6,488 |
| Europa Universalis: Crown of the North (2000) | 76,043 | 15 |
| Europa Universalis: Rome (2008) | 2,467,372 | 429 |
| Europe Ablaze (1985) | 97 | 1 |
| Europe Racer (2001) | 67,443 | 107 |
| European 5-A-Side (1988) | 700 | 8 |
| European Air War (1998) | 120,894 | 81 |
| European Championship 1992 (1992) | 17,483 | 26 |
| European Club Soccer (1992) | 184,037 | 129 |
