| Enigmatis: The Ghosts of Maple Creek (2011) | 1,670,247 | 2,176 |
| Enigmo (2003) | 477,388 | 29 |
| Eniko: Ghosts Of Grace (2023) | 10,458 | 4 |
| Enionax (2022) | 154 | 10 |
| ENKI (2015) | 383,350 | 314 |
| Enlisted (2021) | 280,254,754 | 79,006 |
| Ennichi no Tatsujin (2006) | 2,274,998 | 23 |
| Ennuigi (2015) | 15,448 | 9 |
| Enola (2014) | 54,483,077 | 800 |
| Enotria: The Last Song (2024) | 0 | 0 |
| Ensemble Girls! (2012) | 24,543 | 47 |
| Ensemble Stars (2015) | 12,570,548 | 7,209 |
| Enshrouded World: Home Truths (2018) | 330 | 3 |
| The Ensign (2014) | 122,743 | 30 |
| Enslaved: Odyssey to the West (2010) | 19,688,715 | 11,102 |
| Entanglement (2010) | 2,613,131 | 225 |
| Entasy Online (2022) | 952 | 8 |
| The Entente: Battlefields World War I (2003) | 35,746 | 27 |
| Enter Digiton: Heart of Corruption (2020) | 64,443 | 99 |
| Enter The Cyberjungle (2023) | 0 | 0 |
| Enter the Dominatrix (2013) | 927,146 | 108 |
| Enter the Gun Dungeon (2019) | 2,486 | 9 |
| Enter the Gungeon (2016) | 319,874,100 | 72,407 |
| Enter the Gungeon: House of the Gundead (2020) | 770,041 | 58 |
| Enter the Matrix (2003) | 19,472,374 | 3,650 |
| Enthusia Professional Racing (2005) | 3,463,228 | 1,822 |
| The Entity (2018) | 311,763,631 | 6,293 |
| Entity Researchers (2022) | 11,507 | 14 |
| The Entity Within (2023) | 5,668 | 8 |
| Entombed (1982) | 235,490 | 32 |
| Entombed (1985) | 40,015 | 10 |
| Entomophobia (2022) | 5,923 | 23 |
| Entomorph: Plague of the Darkfall (1995) | 49,609 | 78 |
| Entrepreneurial tycoon (2023) | 0 | 0 |
| Entropia Universe (2003) | 23,211,470 | 21,858 |
| Entropic Float: This World Will Decay And Disappear (2022) | 44 | 2 |
| Entropy (2013) | 900,436 | 740 |
| Entropy : Zero (2017) | 2,367,988 | 3,111 |
| The Entropy Centre (2022) | 5,421,622 | 4,428 |
| Entwined (2014) | 1,731,421 | 840 |
| Enviro-Bear 2000: Operation: Hibernation (2009) | 225,375 | 37 |
| Enviro-Bear 2010 (2009) | 477,206 | 65 |
| Environmental Station Alpha (2015) | 970,902 | 1,138 |
| Enworden (2022) | 126 | 4 |
| ENYO Arcade (2015) | 2,682 | 14 |
| ENZBOTS (2019) | 164 | 3 |
| EOE: Eve of Extinction (2002) | 232,806 | 239 |
| Eol-ui Moheom (1995) | 4,102 | 9 |
| Eon Altar (2016) | 32,198 | 57 |
| EON Fighter (2022) | 8,285 | 52 |
| Eon of the Green (2023) | 15 | 3 |
| Epanalepsis (2015) | 564 | 10 |
| Ephemeral -Fantasy on Dark- (2018) | 808,667 | 165 |
| Ephemeral Fantasia (2000) | 161,793 | 441 |
| Ephemeral Tale (2020) | 8,056 | 65 |
| Epic (1992) | 17,330,054 | 324 |
| Epic 7 (2011) | 59,680 | 76 |
| Epic Adventures: Cursed Onboard (2012) | 20,227 | 25 |
| Epic Arena (2015) | 144,896 | 104 |
| Epic Astro Story (2011) | 59,928 | 108 |
| Epic Battle Fantasy 2 (2009) | 1,022,149 | 306 |
| Epic Battle Fantasy 3 (2010) | 5,061,067 | 2,073 |
| Epic Battle Fantasy 4 (2013) | 3,890,798 | 3,388 |
| Epic Battle Fantasy 5 (2018) | 9,760,455 | 7,505 |
| Epic Battle Fantasy Collection (2022) | 58,082 | 42 |
| Epic Battle Fantasy: Adventure Story (2011) | 927,616 | 1,201 |
| Epic Battle Simulator 2 (2017) | 32,346,604 | 2,151 |
| ePic Character Generator (2015) | 3,438 | 4 |
| Epic Chef (2021) | 3,005,245 | 1,764 |
| Epic Dumpster Bear: Dumpster Fire Redux (2018) | 298,452 | 178 |
| Epic Escapes: Dark Seas (2011) | 1,680 | 9 |
| Epic Fantasy Battle Simulator (2021) | 10,266,716 | 843 |
| Epic Food Fight (2019) | 209,017 | 25 |
| Epic Fun (2019) | 798,907 | 68 |
| EPIC KNIGHT (2022) | 51,459 | 45 |
