| Defender (2002) | 7,528,177 | 839 |
| Defender 2000 (1996) | 57,767 | 105 |
| Defender Bros (2024) | 82,770 | 113 |
| Defender Chronicles: Legend of the Desert King (2009) | 149,478 | 26 |
| Defender Legends: New Era (2019) | 26,415 | 19 |
| Defender of Kuiper Belt (2021) | 42 | 1 |
| Defender of the Crown (1986) | 2,688,136 | 788 |
| Defender of the Crown: Heroes Live Forever (2007) | 3,484 | 10 |
| Defender's Quest (2012) | 479,055 | 557 |
| Defender's Quest: Valley of the Forgotten (2016) | 243,715 | 523 |
| Defender's Squad: The Last Ride (2025) | 0 | 0 |
| Defenders of Ardania (2011) | 648,323 | 264 |
| Defenders of Cardom (2023) | 2,060 | 7 |
| Defenders of Dynatron City (1992) | 232,143 | 121 |
| Defenders of Ekron (2017) | 26 | 1 |
| Defenders of Oasis (1992) | 423,218 | 354 |
| Defenders of Tetsoidea (2017) | 0 | 0 |
| Defenders of the Earth (1990) | 1,367,737 | 337 |
| Defenders of Time (2014) | 411,056 | 48 |
| The Defenders: The Second Wave (2015) | 1,888 | 10 |
| Defendin' de Penguin (2008) | 146,590 | 19 |
| Defending Earth (2023) | 268,680 | 13 |
| Defending Lydia Collier (2022) | 7,221 | 24 |
| DEFENDit (2024) | 16 | 8 |
| Defendoooooor!! (2017) | 1,081 | 7 |
| Defendópolis (2024) | 0 | 0 |
| DEFENDUN (2023) | 26,390 | 13 |
| Defense and Revenge (2020) | 29,931 | 9 |
| Defense Breakers (2024) | 121,498 | 18 |
| Defense Clicker (2017) | 8,172 | 19 |
| Defense Grid 2 (2014) | 1,628,754 | 2,808 |
| Defense Grid: The Awakening (2008) | 2,343,780 | 3,324 |
| Defense of Egypt: Cleopatra Mission (2016) | 36,173 | 7 |
| Defense of Roman Britain (2017) | 63,088 | 17 |
| Defense of the Dauntless (2024) | 0 | 0 |
| Defense of the Earth (2024) | 48 | 3 |
| Defense of the Middle Kingdom (2010) | 1,252 | 2 |
| Defense Task Force (2018) | 43,288 | 49 |
| Defense War (2020) | 558,246 | 433 |
| Defentron (2020) | 3,051 | 25 |
| Defi Gravity (2023) | 130 | 6 |
| Defiance (1997) | 96,833 | 12 |
| Defiance (2013) | 26,135,198 | 7,740 |
| Defiance 2050 (2018) | 6,622,284 | 6,342 |
| Deficis (2015) | 4,977 | 11 |
| Definitely Not Fried Chicken (2021) | 2,431,410 | 1,452 |
| Deflection (2021) | 216,146 | 88 |
| Deflector (2023) | 782,718 | 417 |
| Deflektor (1987) | 46,638 | 85 |
| Deflex (1981) | 15,286 | 6 |
| Deformers (2017) | 4,762,136 | 365 |
| Defunct (2016) | 3,515,804 | 1,413 |
| Defy Gravity Extended (2011) | 375,818 | 88 |
| Degraman: Act I. Vincent (2021) | 23,369 | 92 |
| Degraman: Act II. Victor (2025) | 13 | 1 |
| Degrees of Separation (2019) | 5,512,686 | 1,476 |
| Deichgraf (2021) | 2,592 | 5 |
| Deiland (2016) | 1,857,678 | 1,971 |
| Deisim (2022) | 84,848,649 | 535 |
| Deitrus (2024) | 25 | 2 |
| Deity Quest (2015) | 1,216 | 10 |
| Deitydead：Elder Trial (2024) | 0 | 0 |
| Déjà Drift (2022) | 320 | 10 |
| Deja Vu II: Lost in Las Vegas (1988) | 146,711 | 87 |
| Dekamara (2025) | 211 | 4 |
| Dekaron (2004) | 2,486,071 | 1,787 |
| Dekaron M (2021) | 1,350,935 | 404 |
| Dekitate High School (1995) | 10,423 | 19 |
| Delearnia: Fractions of Hope (2024) | 1,160 | 13 |
| DELETE AFTER READING (2023) | 5,890 | 47 |
| Delicious - Emily's Road Trip (2019) | 248,731 | 604 |
| Delicious Dungeon (2023) | 3,004,134 | 72 |
| Delicious Fruitworld (2021) | 0 | 0 |
| Delicious! Pretty Girls Mahjong Solitaire (2016) | 477,867 | 434 |
| DeLight: The Journey Home (2020) | 125,148 | 141 |
