| Downhill Pro Racer (2023) | 201 | 3 |
| Downstream Panic! (2008) | 45,798 | 20 |
| Downtown Drift (2019) | 471,703 | 99 |
| Downtown Run (2003) | 199,999 | 168 |
| Downward Spear (2023) | 677 | 6 |
| Downward Spiral: Prologue (2017) | 2,808,661 | 589 |
| Downwell (2015) | 6,160,169 | 2,957 |
| Dowon (2024) | 2,152 | 5 |
| DPS IDLE (2021) | 60,141 | 46 |
| DPS IDLE 2 (2024) | 583 | 20 |
| Dr Carter and the Wheels of Salvation (2005) | 1,124 | 2 |
| Dr Iwan: Evolution (2021) | 14 | 1 |
| Dr Kawashima's Brain Training for Nintendo Switch (2019) | 4,476,313 | 292 |
| Dr Muddles and the Cursed Library (2024) | 0 | 0 |
| Dr Seuss' The Cat in the Hat (2003) | 1,498,563 | 309 |
| Dr. Blob's Organism (2003) | 4,786 | 3 |
| Dr. Brain Thinking Games IQ Adventures (1999) | 358 | 1 |
| Dr. Brain: Action Reaction (1999) | 6,316 | 8 |
| Dr. Chaos (1987) | 285,812 | 285 |
| Dr. Drago's Madcap Chase (1995) | 59,302 | 113 |
| Dr. Driving (2013) | 46,842,858 | 10,089 |
| Dr. Emmerson's Nocturnes (2024) | 1,066 | 20 |
| Dr. Fetus' Mean Meat Machine (2023) | 896,994 | 583 |
| Dr. Finklestein's Marvelous Room (2025) | 22,452 | 22 |
| Dr. Franken (1992) | 411,127 | 359 |
| Dr. Franken II (1997) | 7,676 | 35 |
| Dr. Jekyll and Mr. Hyde (1988) | 24,028,135 | 991 |
| Dr. Langeskov, The Tiger, and The Terribly Cursed Emerald: A Whirlwind Heist (2015) | 6,112,644 | 1,130 |
| Dr. Luigi (2013) | 6,351,105 | 492 |
| Dr. Lunatic Supreme with Cheese (2003) | 34,995 | 129 |
| Dr. Mario (1990) | 40,655,970 | 6,950 |
| Dr. Mario 64 (2001) | 1,979,043 | 962 |
| Dr. Mario Express (2008) | 39,014 | 26 |
| Dr. Mario Online Rx (2008) | 1,145,896 | 313 |
| Dr. Mario World (2019) | 21,584,992 | 5,844 |
| Dr. Mario: Miracle Cure (2015) | 859,178 | 169 |
| Dr. Muto (2002) | 898,705 | 319 |
| Dr. Professor Scientist's Weapons Testing Facility (2022) | 8,676 | 27 |
| Dr. Robotnik's Mean Bean Machine (1993) | 27,120,179 | 4,753 |
| Dr. Rudy (1992) | 808 | 3 |
| Dr. Seuss' Fix-Up the Mix-Up Puzzler (1984) | 2,102 | 11 |
| Dr. Seuss: How the Grinch Stole Christmas! (2007) | 5,728,433 | 100 |
| Dr. Spacezoo (2016) | 40,680 | 8 |
| Dr. Stop! (1992) | 1,398 | 6 |
| Dr. Sudoku (2006) | 5,296 | 126 |
| Dr. What & Detective Son (2024) | 0 | 0 |
| Dr. Wise: Medical Mysteries (2012) | 5,140 | 4 |
| Dr. Wong's Jacks+ Video Poker (1992) | 169 | 1 |
| Dr. Yaga Lost House (2024) | 476 | 12 |
| DR4X (2022) | 2,481 | 31 |
| Drabidiboo (2021) | 238 | 2 |
| Drachen von Laas (1991) | 5,875 | 34 |
| Draco Dragon Sim (2020) | 0 | 0 |
| Draco Knight (2022) | 2,799 | 34 |
| Draco Space X (2021) | 0 | 0 |
| DracoFighter (2022) | 2,428 | 18 |
| DRACOMATON (2023) | 957 | 7 |
| Draconia (2022) | 4,487,970 | 1,085 |
| Draconian (1984) | 1,099,133 | 141 |
| Draconic Echoes: The Ardent War (2019) | 111 | 2 |
| Draconus (1988) | 143,418 | 106 |
| Draconus: Cult of the Wyrm (2000) | 283,737 | 290 |
| Dracoslayer (2023) | 519,131 | 124 |
| Dracula 2: The Last Sanctuary (2000) | 2,005,667 | 716 |
| Dracula 3: The Path of the Dragon (2008) | 2,243,268 | 540 |
| Dracula 4: The Shadow of the Dragon (2013) | 766,631 | 237 |
| Dracula 5: The Blood Legacy (2013) | 391,920 | 157 |
| Dracula Awakens (2024) | 1,149 | 19 |
| Dracula the Undead (1991) | 32,408 | 51 |
| Dracula Twins (2006) | 58,450 | 79 |
| Dracula Unleashed (1993) | 880,258 | 175 |
| Dracula's Legacy (2015) | 122,106 | 341 |
| Dracula: A Gothic RPG (2024) | 0 | 0 |
| Dracula: Origin (2008) | 829,680 | 780 |
| Dracula: Resurrection (2000) | 2,546,411 | 862 |
