| Down the Drain (2022) | 1,822,546 | 159 |
| Down The Rabbit Hole (2020) | 95,053,516 | 2,283 |
| Down the World: Mervil's Ambition (1994) | 30,074 | 88 |
| Down to Earth (1987) | 16,436,427 | 401 |
| Downbreak (2018) | 96,072 | 5 |
| Downfall (2009) | 23,903,670 | 2,854 |
| Downforce (2002) | 2,327,955 | 271 |
| Downhill Bikers (1997) | 306 | 1 |
| Downhill Bowling (2008) | 5,035 | 3 |
| Downhill Challenge (1987) | 37,414 | 39 |
| Downhill Domination (2003) | 50,467,378 | 9,180 |
| Downhill Pro Racer (2023) | 201 | 3 |
| Downstream Panic! (2008) | 45,798 | 20 |
| Downtown Drift (2019) | 471,736 | 100 |
| Downtown Run (2003) | 200,057 | 169 |
| Downward Spear (2023) | 677 | 6 |
| Downward Spiral: Horus Station (2018) | 0 | 0 |
| Downward Spiral: Prologue (2017) | 2,810,279 | 592 |
| Downwell (2015) | 6,170,028 | 2,967 |
| Dowon (2024) | 2,194 | 5 |
| DPS IDLE (2021) | 60,141 | 46 |
| DPS IDLE 2 (2024) | 583 | 20 |
| Dr Carter and the Wheels of Salvation (2005) | 1,124 | 2 |
| Dr Iwan: Evolution (2021) | 14 | 1 |
| Dr Kawashima's Brain Training for Nintendo Switch (2019) | 4,476,366 | 293 |
| Dr Muddles and the Cursed Library (2024) | 0 | 0 |
| Dr Seuss' The Cat in the Hat (2003) | 1,502,105 | 310 |
| Dr. Blob's Organism (2003) | 4,786 | 3 |
| Dr. Brain Thinking Games IQ Adventures (1999) | 358 | 1 |
| Dr. Brain: Action Reaction (1999) | 6,741 | 8 |
| Dr. Chaos (1987) | 286,095 | 287 |
| Dr. Drago's Madcap Chase (1995) | 59,313 | 113 |
| Dr. Driving (2013) | 48,126,498 | 10,203 |
| Dr. Emmerson's Nocturnes (2024) | 1,066 | 20 |
| Dr. Fetus' Mean Meat Machine (2023) | 902,296 | 604 |
| Dr. Finklestein's Marvelous Room (2025) | 22,461 | 22 |
| Dr. Franken (1992) | 411,586 | 361 |
| Dr. Franken II (1997) | 7,676 | 35 |
| Dr. Jekyll and Mr. Hyde (1988) | 24,036,170 | 1,000 |
| Dr. Langeskov, The Tiger, and The Terribly Cursed Emerald: A Whirlwind Heist (2015) | 6,112,678 | 1,131 |
| Dr. Luigi (2013) | 6,359,932 | 510 |
| Dr. Lunatic Supreme with Cheese (2003) | 35,000 | 129 |
| Dr. Mario (1990) | 40,701,027 | 7,030 |
| Dr. Mario 64 (2001) | 1,982,648 | 968 |
| Dr. Mario Express (2008) | 40,118 | 28 |
| Dr. Mario Online Rx (2008) | 1,150,096 | 315 |
| Dr. Mario World (2019) | 21,585,082 | 5,844 |
| Dr. Mario: Miracle Cure (2015) | 859,190 | 170 |
| Dr. Muto (2002) | 899,396 | 325 |
| Dr. Professor Scientist's Weapons Testing Facility (2022) | 8,676 | 27 |
| Dr. Robotnik's Mean Bean Machine (1993) | 27,167,180 | 4,809 |
| Dr. Rudy (1992) | 808 | 3 |
| Dr. Seuss' Fix-Up the Mix-Up Puzzler (1984) | 2,102 | 11 |
| Dr. Seuss: How the Grinch Stole Christmas! (2007) | 5,728,433 | 100 |
| Dr. Spacezoo (2016) | 40,680 | 8 |
| Dr. Stop! (1992) | 1,398 | 6 |
| Dr. Sudoku (2006) | 5,825 | 127 |
| Dr. What & Detective Son (2024) | 0 | 0 |
| Dr. Wise: Medical Mysteries (2012) | 5,140 | 4 |
| Dr. Wong's Jacks+ Video Poker (1992) | 169 | 1 |
| Dr. Yaga Lost House (2024) | 476 | 12 |
| DR4X (2022) | 2,481 | 31 |
| Drabidiboo (2021) | 238 | 2 |
| Drachen von Laas (1991) | 5,875 | 34 |
| Draco Dragon Sim (2020) | 0 | 0 |
| Draco Knight (2022) | 2,799 | 34 |
| Draco Space X (2021) | 0 | 0 |
| DracoFighter (2022) | 2,428 | 18 |
| DRACOMATON (2023) | 10,922 | 24 |
| Draconia (2022) | 4,494,075 | 1,090 |
| Draconian (1984) | 1,099,144 | 141 |
| Draconic Echoes: The Ardent War (2019) | 111 | 2 |
| Draconus (1988) | 143,419 | 106 |
| Draconus: Cult of the Wyrm (2000) | 283,866 | 296 |
| Dracoslayer (2023) | 519,235 | 125 |
