| Down in the Dumps (1996) | 2,300,322 | 56 |
| Down Load 2 (1991) | 79,515 | 119 |
| Down the Drain (2022) | 1,982,898 | 169 |
| Down The Rabbit Hole (2020) | 99,482,393 | 2,444 |
| Down the World: Mervil's Ambition (1994) | 30,104 | 90 |
| Down to Earth (1987) | 16,436,595 | 403 |
| Down with the Ship (2026) | 41,602 | 10 |
| Downbreak (2018) | 96,072 | 5 |
| Downfall (2009) | 63,843,391 | 3,019 |
| Downforce (2002) | 2,328,428 | 277 |
| Downhill Bikers (1997) | 2,290 | 4 |
| Downhill Bowling (2008) | 5,035 | 3 |
| Downhill Challenge (1987) | 37,840 | 40 |
| Downhill Domination (2003) | 51,880,265 | 9,650 |
| Downhill Pro Racer (2023) | 201 | 3 |
| Downstream Panic! (2008) | 45,798 | 20 |
| Downtown Drift (2019) | 471,932 | 109 |
| Downtown Run (2003) | 202,467 | 173 |
| Downward Spear (2023) | 677 | 6 |
| Downward Spiral: Horus Station (2018) | 7 | 1 |
| Downward Spiral: Prologue (2017) | 2,842,020 | 598 |
| Downwell (2015) | 6,197,959 | 3,027 |
| Dowon (2024) | 2,194 | 5 |
| DPS IDLE (2021) | 60,141 | 46 |
| DPS IDLE 2 (2024) | 1,525 | 29 |
| Dr Carter and the Wheels of Salvation (2005) | 1,124 | 2 |
| Dr Iwan: Evolution (2021) | 14 | 1 |
| Dr Kawashima's Brain Training for Nintendo Switch (2019) | 4,476,866 | 295 |
| Dr Muddles and the Cursed Library (2024) | 0 | 0 |
| Dr Seuss' The Cat in the Hat (2003) | 1,515,057 | 316 |
| Dr. Alb's Prodigy (2026) | 0 | 0 |
| Dr. Blob's Organism (2003) | 4,786 | 3 |
| Dr. Brain Thinking Games IQ Adventures (1999) | 806 | 1 |
| Dr. Brain: Action Reaction (1999) | 7,911 | 8 |
| Dr. Chaos (1987) | 297,633 | 298 |
| Dr. Drago's Madcap Chase (1995) | 59,524 | 127 |
| Dr. Driving (2013) | 49,026,193 | 10,498 |
| Dr. Emmerson's Nocturnes (2024) | 1,069 | 21 |
| Dr. Fetus' Mean Meat Machine (2023) | 910,208 | 628 |
| Dr. Finklestein's Marvelous Room (2025) | 24,000 | 23 |
| Dr. Frank's Build a Boyfriend (2018) | 0 | 0 |
| Dr. Franken (1992) | 422,431 | 393 |
| Dr. Franken II (1997) | 8,499 | 37 |
| Dr. Jekyll and Mr. Hyde (1988) | 24,072,628 | 1,054 |
| Dr. Langeskov, The Tiger, and The Terribly Cursed Emerald: A Whirlwind Heist (2015) | 6,137,844 | 1,161 |
| Dr. Luigi (2013) | 6,413,369 | 534 |
| Dr. Lunatic Supreme with Cheese (2003) | 35,015 | 129 |
| Dr. Mario (1990) | 40,879,048 | 7,337 |
| Dr. Mario 64 (2001) | 2,022,406 | 1,032 |
| Dr. Mario Express (2008) | 40,145 | 28 |
| Dr. Mario Online Rx (2008) | 1,171,580 | 324 |
| Dr. Mario World (2019) | 21,595,582 | 5,851 |
| Dr. Mario: Miracle Cure (2015) | 859,193 | 171 |
| Dr. Muto (2002) | 912,583 | 347 |
| Dr. Professor Scientist's Weapons Testing Facility (2022) | 8,676 | 27 |
| Dr. Robotnik's Mean Bean Machine (1993) | 27,811,513 | 5,064 |
| Dr. Rudy (1992) | 808 | 3 |
| Dr. Seuss' Fix-Up the Mix-Up Puzzler (1984) | 2,102 | 11 |
| Dr. Seuss: How the Grinch Stole Christmas! (2007) | 5,730,863 | 106 |
| Dr. Spacezoo (2016) | 40,680 | 8 |
| Dr. Stop! (1992) | 1,831 | 7 |
| Dr. Sudoku (2006) | 5,866 | 127 |
| Dr. What & Detective Son (2024) | 0 | 0 |
| Dr. Wise: Medical Mysteries (2012) | 5,140 | 4 |
| Dr. Wong's Jacks+ Video Poker (1992) | 169 | 1 |
| Dr. Yaga Lost House (2024) | 476 | 12 |
| DR4X (2022) | 2,481 | 31 |
| Drabidiboo (2021) | 238 | 2 |
| Dracamar (2026) | 20,059 | 52 |
| Drachen von Laas (1991) | 5,875 | 34 |
| Draco and the Seven Scales (2026) | 0 | 0 |
| Draco Dragon Sim (2020) | 0 | 0 |
| Draco Knight (2022) | 3,119 | 35 |
| Draco Space X (2021) | 0 | 0 |
| DracoFighter (2022) | 2,435 | 19 |
