| Dr. Alb's Prodigy (2026) | 0 | 0 |
| Dr. Blob's Organism (2003) | 4,786 | 3 |
| Dr. Brain Thinking Games IQ Adventures (1999) | 806 | 1 |
| Dr. Brain: Action Reaction (1999) | 7,911 | 8 |
| Dr. Chaos (1987) | 297,633 | 298 |
| Dr. Drago's Madcap Chase (1995) | 59,524 | 127 |
| Dr. Driving (2013) | 49,025,194 | 10,495 |
| Dr. Emmerson's Nocturnes (2024) | 1,069 | 21 |
| Dr. Fetus' Mean Meat Machine (2023) | 910,208 | 628 |
| Dr. Finklestein's Marvelous Room (2025) | 24,000 | 23 |
| Dr. Frank's Build a Boyfriend (2018) | 0 | 0 |
| Dr. Franken (1992) | 422,431 | 393 |
| Dr. Franken II (1997) | 8,499 | 37 |
| Dr. Jekyll and Mr. Hyde (1988) | 24,072,628 | 1,054 |
| Dr. Langeskov, The Tiger, and The Terribly Cursed Emerald: A Whirlwind Heist (2015) | 6,137,844 | 1,161 |
| Dr. Luigi (2013) | 6,413,369 | 534 |
| Dr. Lunatic Supreme with Cheese (2003) | 35,015 | 129 |
| Dr. Mario (1990) | 40,877,203 | 7,334 |
| Dr. Mario 64 (2001) | 2,021,935 | 1,031 |
| Dr. Mario Express (2008) | 40,145 | 28 |
| Dr. Mario Online Rx (2008) | 1,171,580 | 324 |
| Dr. Mario World (2019) | 21,595,582 | 5,851 |
| Dr. Mario: Miracle Cure (2015) | 859,193 | 171 |
| Dr. Muto (2002) | 912,583 | 347 |
| Dr. Professor Scientist's Weapons Testing Facility (2022) | 8,676 | 27 |
| Dr. Robotnik's Mean Bean Machine (1993) | 27,811,439 | 5,063 |
| Dr. Rudy (1992) | 808 | 3 |
| Dr. Seuss' Fix-Up the Mix-Up Puzzler (1984) | 2,102 | 11 |
| Dr. Seuss: How the Grinch Stole Christmas! (2007) | 5,730,863 | 106 |
| Dr. Spacezoo (2016) | 40,680 | 8 |
| Dr. Stop! (1992) | 1,831 | 7 |
| Dr. Sudoku (2006) | 5,866 | 127 |
| Dr. What & Detective Son (2024) | 0 | 0 |
| Dr. Wise: Medical Mysteries (2012) | 5,140 | 4 |
| Dr. Wong's Jacks+ Video Poker (1992) | 169 | 1 |
| Dr. Yaga Lost House (2024) | 476 | 12 |
| DR4X (2022) | 2,481 | 31 |
| Drabidiboo (2021) | 238 | 2 |
| Dracamar (2026) | 20,059 | 52 |
| Drachen von Laas (1991) | 5,875 | 34 |
| Draco Dragon Sim (2020) | 0 | 0 |
| Draco Knight (2022) | 3,119 | 35 |
| Draco Space X (2021) | 0 | 0 |
| DracoFighter (2022) | 2,435 | 19 |
| DRACOMATON (2023) | 17,328 | 37 |
| Draconia (2022) | 4,499,294 | 1,101 |
| Draconian (1984) | 1,118,310 | 201 |
| Draconic Echoes: The Ardent War (2019) | 111 | 2 |
| Draconus (1988) | 144,789 | 109 |
| Draconus: Cult of the Wyrm (2000) | 285,610 | 300 |
| Dracoslayer (2023) | 528,212 | 129 |
| Dracula 2: The Last Sanctuary (2000) | 2,005,954 | 729 |
| Dracula 3: The Path of the Dragon (2008) | 2,284,972 | 560 |
| Dracula 4: The Shadow of the Dragon (2013) | 766,699 | 245 |
| Dracula 5: The Blood Legacy (2013) | 392,117 | 179 |
| Dracula Awakens (2024) | 152,553 | 23 |
| Dracula the Undead (1991) | 35,155 | 54 |
| Dracula Twins (2006) | 58,807 | 84 |
| Dracula Unleashed (1993) | 884,392 | 183 |
| Dracula's Legacy (2015) | 122,678 | 347 |
| Dracula: A Gothic RPG (2024) | 0 | 0 |
| Dracula: Origin (2008) | 835,173 | 852 |
| Dracula: Resurrection (2000) | 2,654,654 | 890 |
| Dracula: Vampires vs. Zombies (2017) | 0 | 0 |
| Draft Day Sports: Pro Basketball 2023 (2022) | 15,478 | 33 |
| Draft of Darkness (2021) | 72,325 | 110 |
| Drag Race Eliminator (1986) | 564 | 5 |
| Drag Racer World (2012) | 5,236 | 3 |
| Drag Racer: Flash Game (2003) | 5,133 | 12 |
| Drag Racer: Perfect Run (2009) | 17,433 | 17 |
| Drag Racing Rivals (2020) | 30,648 | 33 |
| Drag Star! (2019) | 198,794 | 103 |
| Dragalia Lost (2018) | 57,325,192 | 26,412 |
| Dragenas (2025) | 0 | 0 |
| Draggin' (2025) | 42,926 | 3 |
