| Default Unreal Physics and Assets AKA DUPA Project (2020) | 0 | 0 |
| DEFCON (2006) | 8,851,049 | 386 |
| Defcon 5 (1995) | 68,752 | 101 |
| DEFCON: Xenos (2023) | 748 | 13 |
| DEFEAT THE GOBLIN KING (2026) | 0 | 0 |
| Defeated Girl (2020) | 264 | 16 |
| DefeatMe (2009) | 1,655 | 4 |
| Defect Process (2022) | 139 | 1 |
| Defective Holiday (2020) | 31,520 | 16 |
| Defector (2019) | 18,642,315 | 371 |
| Defence of the Arcane Realms (2024) | 12 | 1 |
| Defend from Candyland! (2023) | 990 | 22 |
| Defend The Alamo (1994) | 6,083 | 3 |
| Defend The Bits TD (2022) | 10,108 | 49 |
| Defend The Highlands (2015) | 92,453 | 45 |
| Defend the Highlands: World Tour (2018) | 3,806 | 11 |
| Defend the Rook (2021) | 561,442 | 426 |
| Defend Till Sunshine (2023) | 35,688 | 14 |
| Defend Your Buttress (2017) | 41 | 3 |
| Defend Your Castle (2008) | 17,166,819 | 531 |
| Defend Your Crypt (2016) | 25,821 | 44 |
| Defender (1981) | 1,258,766 | 1,002 |
| Defender (2002) | 7,528,263 | 839 |
| Defender 2000 (1996) | 57,940 | 107 |
| Defender Bros (2024) | 82,778 | 113 |
| Defender Chronicles: Legend of the Desert King (2009) | 149,484 | 26 |
| Defender Legends: New Era (2019) | 26,415 | 19 |
| Defender of Kuiper Belt (2021) | 42 | 1 |
| Defender of the Crown (1986) | 2,692,908 | 797 |
| Defender of the Crown: Heroes Live Forever (2007) | 3,484 | 10 |
| Defender's Quest (2012) | 479,055 | 557 |
| Defender's Quest 2: Mists of Ruin (2025) | 0 | 0 |
| Defender's Quest: Valley of the Forgotten (2016) | 243,726 | 524 |
| Defender's Squad: The Last Ride (2025) | 0 | 0 |
| Defenders of Ardania (2011) | 648,330 | 264 |
| Defenders of Cardom (2023) | 2,062 | 7 |
| Defenders of Dynatron City (1992) | 232,156 | 122 |
| Defenders of Ekron (2017) | 26 | 1 |
| Defenders of Oasis (1992) | 423,325 | 355 |
| Defenders of Tetsoidea (2017) | 0 | 0 |
| Defenders of the Earth (1990) | 1,367,813 | 337 |
| Defenders of Time (2014) | 411,060 | 48 |
| The Defenders: The Second Wave (2015) | 1,888 | 10 |
| Defendin' de Penguin (2008) | 146,590 | 19 |
| Defending Earth (2023) | 268,680 | 13 |
| Defending Lydia Collier (2022) | 7,221 | 24 |
| DEFENDit (2024) | 16 | 8 |
| Defendoooooor!! (2017) | 1,081 | 7 |
| Defendópolis (2024) | 0 | 0 |
| DEFENDUN (2023) | 26,390 | 13 |
| Defense and Revenge (2020) | 29,931 | 9 |
| Defense Breakers (2024) | 121,498 | 18 |
| Defense Clicker (2017) | 8,172 | 19 |
| Defense Grid 2 (2014) | 1,628,911 | 2,809 |
| Defense Grid: The Awakening (2008) | 2,343,906 | 3,326 |
| Defense of Egypt: Cleopatra Mission (2016) | 36,173 | 7 |
| Defense Of Fort Burton (2025) | 0 | 0 |
| Defense of Roman Britain (2017) | 63,088 | 17 |
| Defense of the Dauntless (2024) | 0 | 0 |
| Defense of the Earth (2024) | 48 | 3 |
| Defense of the Middle Kingdom (2010) | 1,252 | 2 |
| Defense Task Force (2018) | 43,288 | 49 |
| Defense War (2020) | 558,292 | 434 |
| Defentron (2020) | 3,051 | 25 |
| Defi Gravity (2023) | 130 | 6 |
| Defiance (1997) | 96,833 | 12 |
| Defiance (2013) | 26,135,806 | 7,739 |
| Defiance 2050 (2018) | 6,622,349 | 6,342 |
| Deficis (2015) | 4,977 | 11 |
| Defiled West (2026) | 0 | 0 |
| Definitely Not Fried Chicken (2021) | 2,431,613 | 1,455 |
| DEFLATE (2026) | 0 | 0 |
| Deflection (2021) | 216,146 | 88 |
| Deflector (2023) | 782,720 | 417 |
| Deflektor (1987) | 46,638 | 85 |
