| Destiny's Sword (2022) | 314,473 | 155 |
| Destiny: World Domination from Stone Age to Space Age (1996) | 2,742 | 2 |
| Destrega (1998) | 1,087,884 | 521 |
| Destropolis (2020) | 140,033 | 153 |
| Destroy All Humans! (2005) | 37,546,306 | 12,810 |
| Destroy All Humans! (2020) | 87,469,967 | 23,978 |
| Destroy All Humans! 2 (2006) | 12,457,617 | 7,821 |
| Destroy All Humans! 2 - Reprobed (2022) | 30,929,174 | 12,018 |
| Destroy All Humans! Big Willy Unleashed (2008) | 663,629 | 217 |
| Destroy All Humans! Path of the Furon (2008) | 6,134,484 | 807 |
| Destroy Geometric Shapes (2021) | 63 | 3 |
| Destroy Space Aliens (2017) | 24 | 6 |
| Destroy The Monoliths (2023) | 65,051 | 33 |
| Destroy the Wall (2026) | 0 | 0 |
| Destroyer (1977) | 5,278,131 | 315 |
| Destroyer (1986) | 10,692 | 20 |
| Destroyer Command (2002) | 48,901 | 29 |
| Destroyer of Worlds (2021) | 7,864,710 | 878 |
| Destroyer: Invasion (2017) | 0 | 0 |
| Destroyer: The U-Boat Hunter (2022) | 3,887,098 | 584 |
| Destruction (2018) | 21,235,084 | 1,056 |
| Destruction AllStars (2021) | 28,615,231 | 7,641 |
| Destruction Derby (1975) | 5,862 | 3 |
| Destruction Derby (1995) | 7,610,198 | 1,315 |
| Destruction Derby 2 (1996) | 2,672,286 | 1,134 |
| Destruction Derby 3 (2000) | 7,277 | 5 |
| Destruction Derby 64 (1999) | 421,902 | 642 |
| Destruction Derby Arenas (2004) | 1,072,466 | 822 |
| Destruction Derby Raw (2000) | 599,178 | 495 |
| Destructivator 2 (2020) | 5,972 | 62 |
| Destructor Tanks (2022) | 174 | 8 |
| DESTRUCTURE: Among Debris (2023) | 19,524 | 123 |
| Desvelado (2024) | 1,352,591 | 71 |
| DESYNC (2017) | 874,679 | 243 |
| Desynced (2023) | 2,398,742 | 1,486 |
| Detached (2017) | 1,374,082 | 352 |
| Detached: Non-VR Edition (2018) | 36,629 | 27 |
| Detained: Too Good for School (2020) | 70,941 | 85 |
| Detana!! TwinBee (1991) | 614,335 | 612 |
| Detana!! Twinbee Yahoo! Deluxe Pack (1995) | 76,458 | 97 |
| DeTechtive 2112 (2025) | 24,830 | 76 |
| Detect-Dev (2025) | 0 | 1 |
| The Detective (1986) | 0 | 0 |
| DETECTIVE - The Motel (2024) | 11,905 | 29 |
| Detective Agency 2 (2022) | 4,373 | 9 |
| Detective Barbie in The Mystery of the Carnival Caper (1998) | 681,149 | 81 |
| Detective Barbie: The Mystery Cruise (2000) | 1,029,408 | 135 |
| Detective Boiled-Hard / Case File - Death of the Space Dino Hunter (2020) | 97 | 3 |
| Detective Butler and the King of Hearts (2024) | 0 | 0 |
| Detective Butler: Maiden Voyage Murder (2017) | 1,241 | 66 |
| Detective Case and Clown Bot in: Murder in the Hotel Lisbon (2014) | 28,002 | 43 |
| Detective Case and Clown Bot in: The Express Killer (2018) | 4,186 | 9 |
| Detective Dave (2023) | 14,822 | 3 |
| Detective Di: The Silk Rose Murders (2019) | 82,127 | 206 |
| Detective Dotson (2025) | 882,397 | 198 |
| Detective Driver: Miami Files (2017) | 192,018 | 104 |
| Detective From The Crypt (2021) | 0 | 0 |
| Detective Gallo (2018) | 3,725,027 | 442 |
| Detective Gman (2021) | 11 | 1 |
| Detective Grimoire: Secret of the Swamp (2014) | 466,476 | 430 |
| Detective Hank and the Golden Sneeze (2016) | 24 | 2 |
| Detective Hayseed - Hollywood (2014) | 2,278,689 | 224 |
| Detective Instinct: Farewell, My Beloved (2025) | 48,945 | 129 |
| Detective Jackie - Mystic Case (2019) | 175,267 | 480 |
| Detective March Forward - The Missing Will (2020) | 518 | 1 |
| Detective Mikami (2025) | 0 | 0 |
| Detective Montgomery Fox: The Case of Diamond Necklace (2023) | 122 | 8 |
| Detective Montgomery Fox: The Case of the Missing Ballerinas (2023) | 0 | 0 |
| Detective Montgomery Fox: The Revenge of Victor Draven (2023) | 0 | 0 |
| Detective Pikachu (2016) | 496,687,291 | 13,485 |
| Detective Pikachu Returns (2023) | 8,519,062 | 8,219 |
| Detective Puz (2020) | 171 | 3 |
| Detective Quest: The Glass Slipper (2012) | 2,801 | 7 |
| Detective Ridelle (2024) | 379 | 14 |
| Detective Rosie Morgan: Death at a Dinner Party (2022) | 138 | 1 |
