| The Destiny of Zorro (2008) | 240,534 | 42 |
| Destiny's Divide (2023) | 8,093 | 87 |
| Destiny's Princess: A War Story, A Love Story (2016) | 18,117 | 68 |
| Destiny's Sword (2022) | 314,473 | 155 |
| Destiny: World Domination from Stone Age to Space Age (1996) | 2,742 | 2 |
| Destrega (1998) | 1,087,893 | 521 |
| Destropolis (2020) | 140,038 | 153 |
| Destroy All Humans! (2005) | 37,548,639 | 12,813 |
| Destroy All Humans! (2020) | 87,475,934 | 24,002 |
| Destroy All Humans! 2 (2006) | 12,457,818 | 7,835 |
| Destroy All Humans! 2 - Reprobed (2022) | 30,933,583 | 12,044 |
| Destroy All Humans! Big Willy Unleashed (2008) | 663,630 | 217 |
| Destroy All Humans! Path of the Furon (2008) | 6,134,879 | 809 |
| Destroy Geometric Shapes (2021) | 63 | 3 |
| Destroy Space Aliens (2017) | 24 | 6 |
| Destroy The Monoliths (2023) | 65,051 | 33 |
| Destroy the Wall (2026) | 0 | 0 |
| Destroyer (1977) | 5,278,134 | 315 |
| Destroyer (1986) | 10,692 | 20 |
| Destroyer Command (2002) | 48,988 | 29 |
| Destroyer of Worlds (2021) | 7,868,917 | 881 |
| Destroyer: Invasion (2017) | 0 | 0 |
| Destroyer: The U-Boat Hunter (2022) | 3,902,572 | 584 |
| Destruction (2018) | 21,235,093 | 1,056 |
| Destruction AllStars (2021) | 28,616,293 | 7,646 |
| Destruction Derby (1975) | 5,862 | 3 |
| Destruction Derby (1995) | 7,610,261 | 1,316 |
| Destruction Derby 2 (1996) | 2,673,964 | 1,137 |
| Destruction Derby 3 (2000) | 7,277 | 5 |
| Destruction Derby 64 (1999) | 421,959 | 643 |
| Destruction Derby Arenas (2004) | 1,072,586 | 823 |
| Destruction Derby Raw (2000) | 601,887 | 500 |
| Destructivator 2 (2020) | 5,973 | 62 |
| Destructor Tanks (2022) | 174 | 8 |
| DESTRUCTURE: Among Debris (2023) | 19,531 | 123 |
| Desvelado (2024) | 1,353,067 | 72 |
| DESYNC (2017) | 874,746 | 243 |
| Desynced (2023) | 2,648,499 | 1,518 |
| Detached (2017) | 1,374,082 | 352 |
| Detached: Non-VR Edition (2018) | 36,629 | 27 |
| Detained: Too Good for School (2020) | 70,941 | 85 |
| Detana!! TwinBee (1991) | 614,402 | 613 |
| Detana!! Twinbee Yahoo! Deluxe Pack (1995) | 76,458 | 97 |
| DeTechtive 2112 (2025) | 24,831 | 76 |
| Detect-Dev (2025) | 0 | 1 |
| The Detective (1986) | 1,735,933 | 232 |
| DETECTIVE - The Motel (2024) | 11,905 | 29 |
| Detective Agency 2 (2022) | 4,373 | 9 |
| Detective Barbie in The Mystery of the Carnival Caper (1998) | 681,482 | 81 |
| Detective Barbie: The Mystery Cruise (2000) | 1,029,408 | 135 |
| Detective Boiled-Hard / Case File - Death of the Space Dino Hunter (2020) | 97 | 3 |
| Detective Butler and the King of Hearts (2024) | 0 | 0 |
| Detective Butler: Maiden Voyage Murder (2017) | 1,241 | 66 |
| Detective Case and Clown Bot in: Murder in the Hotel Lisbon (2014) | 28,002 | 43 |
| Detective Case and Clown Bot in: The Express Killer (2018) | 4,186 | 9 |
| Detective Dave (2023) | 14,822 | 3 |
| Detective Di: The Silk Rose Murders (2019) | 82,127 | 206 |
| Detective Dotson (2025) | 883,262 | 202 |
| Detective Driver: Miami Files (2017) | 192,018 | 104 |
| Detective From The Crypt (2021) | 46,982 | 160 |
| Detective Gallo (2018) | 3,725,031 | 442 |
| Detective Gman (2021) | 11 | 1 |
| Detective Grimoire: Secret of the Swamp (2014) | 466,492 | 430 |
| Detective Hank and the Golden Sneeze (2016) | 24 | 2 |
| Detective Hayseed - Hollywood (2014) | 2,278,721 | 224 |
| Detective Instinct: Farewell, My Beloved (2025) | 50,120 | 137 |
| Detective Jackie - Mystic Case (2019) | 175,273 | 481 |
| Detective March Forward - The Missing Will (2020) | 518 | 1 |
| Detective Mikami (2025) | 0 | 0 |
| Detective Montgomery Fox: The Case of Diamond Necklace (2023) | 122 | 8 |
| Detective Montgomery Fox: The Case of the Missing Ballerinas (2023) | 0 | 0 |
| Detective Montgomery Fox: The Revenge of Victor Draven (2023) | 0 | 0 |
| Detective Pikachu (2016) | 496,763,926 | 13,504 |
| Detective Pikachu Returns (2023) | 8,526,372 | 8,252 |
| Detective Puz (2020) | 171 | 3 |
