| Desktop Zoo (2024) | 0 | 0 |
| Desolate (2018) | 33,352,191 | 5,314 |
| Desolate City: Last Show (2024) | 5,913 | 12 |
| Desolate Realms (2024) | 13,777 | 4 |
| The Desolate Room (2007) | 821,307 | 94 |
| Desolated District (2025) | 3,411 | 18 |
| Desolation Tycoon (2022) | 98,537 | 33 |
| DESOLATIUM (2024) | 267,144 | 205 |
| Desolator (1986) | 427,075 | 143 |
| Despair 2 (1995) | 107,574 | 24 |
| Despectum Drakone (2022) | 0 | 0 |
| Despelote (2021) | 51,895 | 45 |
| Desperado 2 (1991) | 71,094 | 19 |
| Desperados 2: Cooper's Revenge (2006) | 639,836 | 418 |
| Desperados III (2020) | 41,550,633 | 14,483 |
| Desperados: Wanted Dead or Alive (2001) | 2,018,926 | 1,945 |
| Desperate Housewives: The Game (2006) | 1,922,594 | 388 |
| Desperate Housewives: The Game (2017) | 10,224 | 80 |
| Desperate: Vladivostok (2022) | 33,321 | 67 |
| Despicable Me: Minion Rush (2013) | 1,353,998,984 | 49,928 |
| Despicable Me: The Game (2010) | 4,503,304 | 345 |
| DeSPIRIA (2001) | 338,566 | 371 |
| DESPOSIS (2024) | 289 | 6 |
| Despot's Game (2021) | 6,886,842 | 2,104 |
| Despot's Game: Dystopian Army Builder (2021) | 3,883,453 | 515 |
| Despotism 3k (2018) | 5,614,517 | 835 |
| Dessert Storm (2016) | 11,410 | 50 |
| Dessert Storm Girls (2024) | 6 | 2 |
| Desta: The Memories Between (2023) | 235,952 | 145 |
| Destination Earthstar (1990) | 67,504 | 88 |
| Destination Primus Vita (2018) | 13,392 | 56 |
| Destination: Treasure Island (2006) | 209,925 | 87 |
| Destined to Die (2021) | 65,791 | 29 |
| Destinesia (2023) | 11,107 | 7 |
| Destinies (2021) | 3,457,034 | 1,973 |
| Destiny (2014) | 2,643,976,369 | 457,522 |
| Destiny 2 (2017) | 9,828,943,130 | 1,551,968 |
| Destiny Child (2016) | 35,874,027 | 12,334 |
| Destiny Connect: Tick-Tock Travelers (2019) | 512,712 | 502 |
| Destiny Duel (2023) | 972,381 | 10 |
| Destiny Hunter (2019) | 490,779 | 55 |
| Destiny Knights (2018) | 737,920 | 247 |
| Destiny Links (2009) | 18,171 | 21 |
| Destiny of a Wizard (2017) | 1,764 | 42 |
| Destiny of a Wizard 2: Beyond the Vale (2018) | 459 | 4 |
| Destiny of a Wizard 3: Beyond the World (2023) | 497 | 9 |
| Destiny of an Emperor (1989) | 2,784,943 | 1,851 |
| Destiny of Ancient Kingdoms (2016) | 62,884 | 39 |
| Destiny of Spirits (2014) | 595,014 | 181 |
| Destiny of the World (2022) | 7,133 | 8 |
| The Destiny of Zorro (2008) | 240,489 | 41 |
| Destiny's Divide (2023) | 8,085 | 87 |
| Destiny's Princess: A War Story, A Love Story (2016) | 17,800 | 68 |
| Destiny's Sword (2022) | 240,381 | 154 |
| Destiny: World Domination from Stone Age to Space Age (1996) | 2,582 | 1 |
| Destrega (1998) | 1,087,454 | 519 |
| Destropolis (2020) | 139,876 | 152 |
| Destroy All Humans! (2005) | 37,536,358 | 12,734 |
| Destroy All Humans! (2020) | 87,428,979 | 23,542 |
| Destroy All Humans! 2 (2006) | 12,414,804 | 7,689 |
| Destroy All Humans! 2 - Reprobed (2022) | 30,799,956 | 11,571 |
| Destroy All Humans! Big Willy Unleashed (2008) | 662,666 | 215 |
| Destroy All Humans! Path of the Furon (2008) | 6,127,202 | 754 |
| Destroy Geometric Shapes (2021) | 63 | 3 |
| Destroy Space Aliens (2017) | 24 | 6 |
| Destroy The Monoliths (2023) | 65,032 | 32 |
| Destroyer (1977) | 5,277,224 | 312 |
| Destroyer (1986) | 10,692 | 20 |
| Destroyer Command (2002) | 48,676 | 29 |
| Destroyer of Worlds (2021) | 7,758,653 | 823 |
| Destroyer: Invasion (2017) | 0 | 0 |
| Destroyer: The U-Boat Hunter (2022) | 3,639,854 | 564 |
| Destruction (2018) | 21,234,747 | 1,052 |
| Destruction AllStars (2021) | 28,613,030 | 7,626 |
| Destruction Derby (1975) | 5,612 | 2 |
