| Destroy All Humans! 2 - Reprobed (2022) | 30,951,023 | 12,146 |
| Destroy All Humans! Big Willy Unleashed (2008) | 663,633 | 217 |
| Destroy All Humans! Path of the Furon (2008) | 6,136,025 | 848 |
| Destroy Geometric Shapes (2021) | 63 | 3 |
| Destroy Space Aliens (2017) | 24 | 6 |
| Destroy the Asteroids (2026) | 0 | 0 |
| Destroy The Monoliths (2023) | 65,051 | 33 |
| Destroy the Wall (2026) | 0 | 0 |
| Destroy This Block (2026) | 0 | 0 |
| Destroyer (1977) | 5,278,136 | 315 |
| Destroyer (1986) | 10,692 | 20 |
| Destroyer Command (2002) | 49,158 | 29 |
| Destroyer of Worlds (2021) | 7,960,498 | 894 |
| Destroyer: Invasion (2017) | 0 | 0 |
| Destroyer: The U-Boat Hunter (2022) | 3,912,075 | 586 |
| Destruction (2018) | 21,235,096 | 1,056 |
| Destruction AllStars (2021) | 28,619,947 | 7,655 |
| Destruction Derby (1975) | 5,862 | 3 |
| Destruction Derby (1995) | 7,610,379 | 1,316 |
| Destruction Derby 2 (1996) | 2,678,136 | 1,153 |
| Destruction Derby 3 (2000) | 7,277 | 5 |
| Destruction Derby 64 (1999) | 422,671 | 649 |
| Destruction Derby Arenas (2004) | 1,072,928 | 825 |
| Destruction Derby Raw (2000) | 604,013 | 507 |
| Destructivator 2 (2020) | 5,974 | 62 |
| Destructor Tanks (2022) | 174 | 8 |
| DESTRUCTURE: Among Debris (2023) | 19,531 | 123 |
| Desvelado (2024) | 1,354,991 | 72 |
| DESYNC (2017) | 876,531 | 245 |
| Desynced (2023) | 2,651,658 | 1,533 |
| Detached (2017) | 1,549,364 | 355 |
| Detached: Non-VR Edition (2018) | 36,629 | 27 |
| Detained: Too Good for School (2020) | 70,941 | 85 |
| Detana!! TwinBee (1991) | 616,171 | 616 |
| Detana!! Twinbee Yahoo! Deluxe Pack (1995) | 76,458 | 97 |
| DeTechtive 2112 (2025) | 24,866 | 77 |
| Detect-Dev (2025) | 0 | 1 |
| The Detective (1986) | 1,736,030 | 234 |
| DETECTIVE - Rainy night (2025) | 166 | 3 |
| DETECTIVE - The Motel (2024) | 11,905 | 29 |
| Detective Agency 2 (2022) | 4,373 | 10 |
| Detective Barbie in The Mystery of the Carnival Caper (1998) | 681,936 | 82 |
| Detective Barbie: The Mystery Cruise (2000) | 1,030,871 | 136 |
| Detective Boiled-Hard / Case File - Death of the Space Dino Hunter (2020) | 97 | 3 |
| Detective Butler and the King of Hearts (2024) | 0 | 0 |
| Detective Butler: Maiden Voyage Murder (2017) | 1,241 | 66 |
| Detective Case and Clown Bot in: Murder in the Hotel Lisbon (2014) | 28,002 | 43 |
| Detective Case and Clown Bot in: The Express Killer (2018) | 4,186 | 9 |
| Detective Dave (2023) | 14,822 | 3 |
| Detective Di: The Silk Rose Murders (2019) | 82,165 | 208 |
| Detective Dotson (2025) | 885,338 | 202 |
| Detective Driver: Miami Files (2017) | 192,019 | 104 |
| Detective From The Crypt (2021) | 46,983 | 161 |
| Detective Gallo (2018) | 3,725,069 | 442 |
| Detective Gman (2021) | 11 | 1 |
| Detective Grimoire: Secret of the Swamp (2014) | 606,759 | 431 |
| Detective Hank and the Golden Sneeze (2016) | 24 | 2 |
| Detective Hayseed - Hollywood (2014) | 2,278,760 | 224 |
| Detective Instinct: Farewell, My Beloved (2025) | 53,333 | 142 |
| Detective Jackie - Mystic Case (2019) | 175,334 | 483 |
| Detective March Forward - The Missing Will (2020) | 518 | 1 |
| Detective Mikami (2025) | 0 | 0 |
| Detective Montgomery Fox: The Case of Diamond Necklace (2023) | 122 | 8 |
| Detective Montgomery Fox: The Case of the Missing Ballerinas (2023) | 0 | 0 |
| Detective Montgomery Fox: The Revenge of Victor Draven (2023) | 0 | 0 |
| Detective Pikachu (2016) | 497,030,361 | 13,589 |
| Detective Pikachu Returns (2023) | 8,544,758 | 8,325 |
| Detective Puz (2020) | 171 | 3 |
| Detective Quest: The Glass Slipper (2012) | 2,801 | 7 |
| Detective Ridelle (2024) | 379 | 14 |
| Detective Rosie Morgan: Death at a Dinner Party (2022) | 138 | 1 |
| Detective Rosie Morgan: Murder on the River Thames (2021) | 232 | 1 |
| Detective School Club (2024) | 890 | 8 |
| Detective Secrets Solitaire. The Curse of the Village (2024) | 1,024 | 4 |
| Detective Super Star (2023) | 441 | 5 |
