| Demons' Score (2012) | 459,058 | 80 |
| DemonsAreCrazy (2018) | 288,214 | 184 |
| Demonschool (2024) | 476,178 | 564 |
| Demonsomnia (2024) | 46,377 | 103 |
| DemonStar (1997) | 210,346 | 186 |
| DemonStar: Secret Missions 2 (2003) | 4,831 | 8 |
| Deneb: Across the Stars (2022) | 1,117 | 10 |
| Dengeki Bunko: Fighting Climax (2014) | 11,318,568 | 7,717 |
| Dengeki Gakuen RPG: Cross of Venus (2009) | 98,673 | 73 |
| Denis Through the Drinking Glass (1984) | 2,061 | 6 |
| Denizen (1988) | 965,712 | 92 |
| Denizen (2024) | 7,061,294 | 909 |
| Denizen's Den (2012) | 498 | 4 |
| Denjin Makai (1994) | 567,803 | 368 |
| Denki Blocks! (2002) | 302,373 | 100 |
| Denki Gaka's Bombshell (2017) | 0 | 0 |
| Dennis the Menace (1993) | 82,725,094 | 1,007 |
| Dennou Taisen: DroneZ (2004) | 4,697 | 5 |
| The Denpa Men: They Came By Wave (2012) | 25,970,081 | 2,016 |
| Densetsu no Stafy (2002) | 3,567,503 | 2,488 |
| Densetsu no Stafy 2 (2003) | 743,330 | 1,148 |
| Densetsu no Stafy 3 (2004) | 1,368,190 | 758 |
| Densetsu no Stafy 4 (2006) | 645,673 | 369 |
| Densetsu no Yuusha no Densetsu: Legendary Saga (2010) | 33,635 | 5 |
| Densha de Go! (1997) | 3,776,669 | 1,481 |
| Densha de Go! EX (1998) | 609,978 | 23 |
| Densha de GO! Final (2004) | 770,417 | 231 |
| Densha de Go! Nagoya Railroad (2000) | 7,038 | 21 |
| Densha de GO! Professional (1999) | 5,957 | 10 |
| Densha de Go! Professional 2 (2003) | 540,472 | 134 |
| Dental Strike (2024) | 6 | 2 |
| Dentures and Demons 2 (2020) | 1,251,266 | 537 |
| Depanneur Nocturne (2020) | 18,369 | 55 |
| Department 14 (2023) | 2,541 | 15 |
| Depersonalization (2022) | 79,909 | 247 |
| Depixtion (2019) | 2,267 | 18 |
| DEPO : Death Epileptic Pixel Origins (2022) | 3,876 | 45 |
| Deponia (2012) | 74,230,197 | 17,756 |
| Deponia Doomsday (2016) | 0 | 0 |
| Deponia: The Complete Journey (2014) | 1,159,657 | 6,423 |
| DepowerBall (2023) | 2,807 | 22 |
| Depraved (2018) | 3,362,271 | 1,564 |
| Depression Quest (2013) | 865,825 | 156 |
| Depression The Game (2018) | 123,747 | 31 |
| Depth (2014) | 192,831,107 | 7,963 |
| Depth Dwellers (1994) | 436,120 | 101 |
| Depth Hunter (2012) | 985,091 | 171 |
| Depth Hunter 2: Deep Dive (2014) | 703,819 | 191 |
| Depth of Extinction (2018) | 194,218 | 299 |
| Depthcharge (1977) | 10,789 | 41 |
| Depthris (2023) | 0 | 0 |
| Depths of Dread (2016) | 440 | 2 |
| Depths of Faveg (2024) | 240 | 2 |
| Depths of Helheim (2023) | 13,454 | 4 |
| Depths of Insanity (2023) | 18,338 | 20 |
| Depths of Limbo (2017) | 11,133 | 24 |
| Depths of Madness (2019) | 632,860 | 59 |
| Depths of Peril (2007) | 253,180 | 84 |
| Deputinization (2023) | 1,027 | 5 |
| Der Anzeigenhauptmeister (2024) | 1,464,043 | 44 |
| Der Blaue Diamant (2020) | 0 | 0 |
| Der flinke Architekt (1983) | 947 | 3 |
| Der Fluch der Osterinsel (2010) | 10,938 | 6 |
| Der Geisterjäger / The Ghost Hunter (2021) | 1,096 | 9 |
| Der Geistermeister (2023) | 52 | 2 |
| Der Geisterturm / The Ghost Tower (2020) | 522 | 3 |
| Der Klomanager (2000) | 15,741 | 16 |
| Der Königsruf (2024) | 37 | 1 |
| Der Pfad des Pinguins (2024) | 43 | 3 |
| Der Planer (1994) | 514,253 | 467 |
| Der Schatz der Delfine (2009) | 48 | 2 |
| Déraciné (2018) | 2,388,927 | 633 |
| Derail Valley (2019) | 29,801,325 | 10,887 |
| Derby Jockey 2 (1995) | 11,417 | 9 |
| Derby Jockey: Kishou e no Michi (1994) | 4,849 | 10 |
