| Syobon Action (2007) | 667,184,539 | 9,269 |
| Syphon Filter (1999) | 18,395,886 | 11,687 |
| Syphon Filter 2 (2000) | 8,422,367 | 6,757 |
| Syphon Filter 3 (2001) | 4,797,813 | 4,219 |
| Syphon Filter: Combat Ops (2007) | 39,925 | 24 |
| Syphon Filter: Dark Mirror (2006) | 4,809,003 | 2,167 |
| Syphon Filter: Logan's Shadow (2004) | 0 | 0 |
| Syphon Filter: Logan's Shadow (2007) | 3,293,821 | 1,662 |
| Syphon Filter: The Omega Strain (2004) | 1,838,973 | 1,245 |
| SYREN (2017) | 390,083 | 120 |
| Syren and Friends Roast the Dev (2022) | 0 | 0 |
| Syrian Warfare (2017) | 3,995,955 | 993 |
| Syrup and the Ultimate Sweet (2015) | 1,042,954 | 472 |
| SysOps Saga (2024) | 6,208 | 8 |
| System 15000 (1984) | 2,700 | 3 |
| System Crash (2016) | 1,046,026 | 118 |
| System Critical 2 (2023) | 16,974 | 68 |
| System Flaw (2009) | 20,605 | 30 |
| System Invaders (2020) | 664 | 23 |
| System Protocol One (2010) | 1,276 | 17 |
| System Purge (2022) | 18,054 | 82 |
| System Purge: Hollow Point (2025) | 15 | 1 |
| System Rush (2005) | 18,887 | 25 |
| System Shock (1994) | 11,968,522 | 5,445 |
| System Shock (2023) | 29,374,884 | 14,415 |
| System Shock 2 (1999) | 28,302,054 | 11,971 |
| System Under Surveillance (2022) | 579 | 8 |
| System's Twilight (1994) | 1,057 | 9 |
| Systematic Immunity (2016) | 104,864 | 15 |
| Syvalion (1988) | 395,886 | 234 |
| Szikra (2024) | 632 | 9 |
