| Serious Sam 2 (2005) | 43,152,847 | 16,473 |
| Serious Sam 3: BFE (2011) | 142,483,282 | 25,567 |
| Serious Sam 4 (2020) | 114,740,415 | 33,448 |
| Serious Sam Advance (2004) | 244,109 | 154 |
| Serious Sam Classics: Revolution (2014) | 546,889 | 879 |
| Serious Sam Collection (2020) | 641,244 | 1,685 |
| Serious Sam Double D (2011) | 477,698 | 320 |
| Serious Sam Double D XXL (2013) | 1,047,003 | 167 |
| Serious Sam HD: The First Encounter (2010) | 5,528,276 | 5,823 |
| Serious Sam HD: The Second Encounter (2010) | 8,335,424 | 5,424 |
| Serious Sam VR: The Last Hope (2017) | 3,884,773 | 540 |
| Serious Sam's Bogus Detour (2017) | 0 | 0 |
| Serious Sam: I Hate Running Backwards (2018) | 429,936 | 207 |
| Serious Sam: Kamikaze Attack! (2011) | 580,715 | 133 |
| Serious Sam: Next Encounter (2004) | 1,712,554 | 1,568 |
| Serious Sam: Siberian Mayhem (2022) | 11,062,233 | 8,094 |
| Serious Sam: The First Encounter (2001) | 15,021,141 | 10,685 |
| Serious Sam: The Greek Encounter (2012) | 31,229 | 17 |
| Serious Sam: The Random Encounter (2011) | 1,222,039 | 153 |
| Serious Sam: The Second Encounter (2002) | 17,296,895 | 13,943 |
| Serious Sam: Tormental (2019) | 817,642 | 188 |
| Serious Sam: Tormental (2022) | 142,418 | 165 |
| Serious Scramblers (2018) | 6,199 | 50 |
| Serke (2024) | 93 | 8 |
| Serment - Contract with a Devil (2019) | 13,248 | 64 |
| Serpent (1990) | 53,604 | 39 |
| SERPENT AT THE VERNISSAGE (2025) | 0 | 0 |
| Serpent in the Staglands (2015) | 258,891 | 243 |
| The Serpent of Isis (2009) | 140,113 | 35 |
| The Serpent Rogue (2022) | 1,703,543 | 728 |
| Serpent Showdown (2021) | 10 | 2 |
| The Serpent's Star (1983) | 37,395 | 11 |
| Serpentine (1982) | 5,736,798 | 269 |
| Serre (2025) | 0 | 0 |
| Serum (2024) | 5,263,878 | 1,473 |
| Servant of the Lake (2026) | 1,811 | 7 |
| Servants of Sumomon (2023) | 0 | 0 |
| Service Dog (2026) | 0 | 0 |
| Service with a Shotgun (2025) | 0 | 0 |
| ServiceIT: You can do IT (2024) | 72,180 | 174 |
| Servonauts (2024) | 18,479 | 52 |
| Sery: Into the World of Myths (2026) | 9 | 1 |
| Sesame Street Elmo's Preschool (1996) | 2,521,316 | 145 |
| Sesame Street Sports (2001) | 455,952 | 132 |
| Sesame Street: 123 (1989) | 457,990 | 93 |
| Sesame Street: A-B-C (1989) | 349,015 | 160 |
| Sesame Street: Big Bird's Hide and Speak (1990) | 116,121 | 103 |
| Sesame Street: Cookie's Counting Carnival (2010) | 409,762 | 95 |
| Sesame Street: Countdown (1992) | 1,086,550 | 150 |
| Sesame Street: Counting Cafe (1994) | 103,325 | 70 |
| Sesame Street: Elmo's A-to-Zoo Adventure (2010) | 178,677 | 85 |
| Sesame Street: Elmo's Musical Monsterpiece (2012) | 383,874 | 61 |
| Sesame Street: Letter-Go-Round (1984) | 15,072 | 18 |
| Sesame Street: Numbers (1991) | 251,217 | 51 |
| Sesame Street: Once Upon a Monster (2011) | 1,958,942 | 288 |
| Sesame Street: Ready, Set, Grover! (2011) | 524,042 | 110 |
| Sesame Street: The Adventures of Elmo in Grouchland (1999) | 1,083,568 | 87 |
| Session Seven (2019) | 13,472 | 63 |
| Session: Skate Sim (2022) | 32,124,310 | 18,280 |
| Set Sail! Arena (2024) | 0 | 0 |
| Set Yourself on Fire (2026) | 38 | 1 |
| Setr's Auto Battler (2021) | 5,397 | 12 |
| Settlement Survival (2021) | 30,112,223 | 5,609 |
| Settlement: Colossus (2010) | 16,631 | 44 |
| Settlements Rising (2024) | 394,631 | 270 |
| Settlemoon (2023) | 646 | 25 |
| Settler's Domain (2026) | 0 | 0 |
| Settler's Odyssey (2023) | 0 | 0 |
| The Settlers (1993) | 10,612,505 | 3,677 |
| The Settlers (2019) | 77,039 | 12 |
| The Settlers (2022) | 271,781 | 105 |
| The Settlers 7: Paths to a Kingdom (2010) | 23,384,271 | 2,758 |
| The Settlers II (1996) | 7,625,511 | 6,884 |
| The Settlers III (1998) | 7,309,587 | 6,615 |
| The Settlers IV (2001) | 9,298,225 | 5,267 |
