| Sprint 2 (1976) | 315,683 | 108 |
| Sprint 4 (1977) | 3,179 | 13 |
| Sprint 8 (1977) | 5,547 | 12 |
| Sprint Cars: Road to Knoxville (2006) | 113,433 | 95 |
| Sprint Master (1988) | 28,381 | 38 |
| Sprint Vector (2018) | 4,751,086 | 685 |
| Sprinter Monogatari: Mezase!! Ikkaku Senkin (1995) | 6,862 | 6 |
| Sprite Fantasia (2021) | 1,027,023 | 535 |
| Sprite Lamp (2014) | 0 | 0 |
| Sprite's Honor! (2024) | 49 | 2 |
| SpritePile (2019) | 0 | 0 |
| Spritify (2021) | 0 | 0 |
| Spritz the Happy Onion (2025) | 40 | 1 |
| Sprocket (2021) | 27,740,511 | 1,632 |
| Sproggiwood (2014) | 136,524 | 269 |
| Sproots (2020) | 67,111 | 16 |
| Sprout Valley (2023) | 70,568 | 188 |
| Sprung (2004) | 3,179,615 | 249 |
| Spryward (2022) | 35 | 3 |
| Spud Customs (2024) | 0 | 0 |
| Spud's Adventure (1991) | 36,370 | 58 |
| Spuds Unearthed (2019) | 1,427,763 | 87 |
| SpunkStock: Music Festival (2022) | 65,262 | 12 |
| Spunky: Gangster Simulator (2023) | 0 | 0 |
| Sputnik (2021) | 2,323,322 | 94 |
| Spy 1 Lovecraftian (2024) | 0 | 0 |
| Spy Bot Chronicles (2009) | 12,549 | 15 |
| Spy Fiction (2003) | 745,785 | 286 |
| Spy Fox in Cheese Chase (1998) | 13,342 | 50 |
| Spy Fox in: Hold the Mustard (1999) | 6,776 | 56 |
| Spy Fox In: Hold the Mustard (2014) | 32,082 | 4 |
| Spy Games: Elevator Mission (2007) | 15,488 | 13 |
| Spy Hunter (1983) | 3,149,577 | 1,127 |
| Spy Hunter (2012) | 773,054 | 190 |
| Spy Hunter II (1987) | 18,845 | 29 |
| Spy Kids: All the Time in the World (2011) | 294,279 | 60 |
| Spy Mouse (2011) | 2,436,759 | 166 |
| Spy Muppets: License to Croak (2003) | 408,332 | 110 |
| Spy Robot: Gateways To Humanity (2022) | 309 | 4 |
| SPY RUMBLE (2022) | 737,731 | 368 |
| Spy Snatcher (1992) | 432 | 2 |
| Spy Tactics (2019) | 79,750 | 60 |
| Spy vs. Spy (1984) | 1,680,060 | 447 |
| Spy vs. Spy (2005) | 2,564,721 | 304 |
| Spy vs. Spy II: The Island Caper (1985) | 358,698 | 103 |
| Spy vs. Spy III: Arctic Antics (1986) | 80,196 | 86 |
| The Spy Who Loved Me (1990) | 9,143,042 | 499 |
| The Spy Who Shrunk Me! (2018) | 19,566,354 | 238 |
| Spy's Demise (1982) | 7,502 | 13 |
| Spyborgs (2009) | 470,436 | 333 |
| Spycat (1988) | 973 | 5 |
| Spycraft: The Great Game (1996) | 302,549 | 139 |
| Spyder (2020) | 15,764,772 | 440 |
| SpyFall (2026) | 2,879 | 1 |
| Spyglass Board Games (2007) | 3,431 | 4 |
| Spyhack (2020) | 4,133 | 18 |
| SpyHunter (2001) | 1,135,216 | 481 |
| SpyHunter 2 (2003) | 589,990 | 177 |
| SpyHunter: Nowhere to Run (2006) | 2,765,397 | 362 |
| SpyParty (2018) | 123,596,281 | 1,326 |
| Spyro 2: Ripto's Rage! (1999) | 62,065,221 | 46,972 |
| Spyro 2: Season of Flame (2002) | 332,327 | 828 |
| Spyro Orange: The Cortex Conspiracy (2004) | 1,806,685 | 615 |
| Spyro Reignited Trilogy (2018) | 229,964,009 | 114,680 |
| Spyro the Dragon (1998) | 80,678,496 | 39,845 |
| Spyro: A Hero's Tail (2004) | 11,105,548 | 4,873 |
| Spyro: Attack of the Rhynocs (2003) | 421,285 | 706 |
| Spyro: Enter the Dragonfly (2002) | 9,482,434 | 4,660 |
| Spyro: Season of Ice (2001) | 750,271 | 1,182 |
| Spyro: Shadow Legacy (2005) | 362,977 | 322 |
| Spyro: Year of the Dragon (2000) | 56,377,817 | 32,726 |
| SQIJ! (1986) | 91,819 | 29 |
| Sqoon (1986) | 452,008 | 260 |
| SQR (2025) | 0 | 0 |
| Sqroma (2022) | 670 | 27 |
