| Space BloX (2019) | 12,182 | 3 |
| Space Bob vs. The Replicons (2018) | 95,550 | 9 |
| Space Bomb (2019) | 141 | 2 |
| Space Bomber (1998) | 76,381 | 100 |
| Space Bound (2019) | 62 | 1 |
| Space Box Battle Arena (2022) | 20 | 2 |
| Space Bucks (1996) | 5,989 | 14 |
| Space Bunnies Must Die! (1998) | 28,095 | 23 |
| Space Bunny Explorers (2022) | 57 | 5 |
| Space Bust-a-Move (2008) | 73,272 | 45 |
| Space Castle (2020) | 7,325 | 18 |
| Space Cats (2024) | 51 | 9 |
| Space Cats Tactics (2022) | 34,329 | 94 |
| Space Cavern (1982) | 49,914 | 53 |
| Space Channel 5 (1999) | 7,235,767 | 1,081 |
| Space Channel 5 VR: Kinda Funky News Flash! (2020) | 1,662,019 | 254 |
| Space Channel 5: Part 2 (2002) | 10,780,493 | 1,804 |
| Space Channel 5: Ulala's Cosmic Attack (2003) | 8,028 | 35 |
| Space Cheetah Hyper Runner (2022) | 82 | 1 |
| Space Chimps (2008) | 2,728,114 | 192 |
| Space Choice: Data Analyzer (2021) | 1,490 | 20 |
| Space City - Build Your Empire (2022) | 53 | 2 |
| Space Clash: The Last Frontier (1999) | 17,242 | 41 |
| Space Climber (2019) | 0 | 0 |
| Space Codex (2016) | 2,950 | 7 |
| Space Colonizer (2022) | 4,936 | 10 |
| Space Colonizers Idle Clicker (2018) | 2,271 | 12 |
| Space Colony (2003) | 4,074,727 | 991 |
| Space Combat (2004) | 1,207,200 | 264 |
| Space Commander 9 (2018) | 0 | 0 |
| Space Commander: War and Trade (2020) | 449,343 | 498 |
| Space Company Simulator (2019) | 211,206 | 57 |
| Space Cowboy (2018) | 514,944 | 233 |
| Space Cowboys - Riders of the Storm (2023) | 395 | 3 |
| Space Cows (2019) | 185,394 | 119 |
| SPACE Craft (2020) | 881,962 | 134 |
| Space Crafting (2022) | 28,966 | 5 |
| Space Crew (2020) | 4,384,566 | 2,420 |
| Space Crisis (2020) | 1,020,176 | 49 |
| Space Cruise (2019) | 257 | 2 |
| Space Crusade (1992) | 634,524 | 258 |
| Space Crusade: The Voyage Beyond (1992) | 2,925 | 1 |
| Space Crusaders (2022) | 17,792 | 20 |
| Space Cube Racers (2020) | 0 | 0 |
| Space Cube Tower Defense (2021) | 0 | 0 |
| Space Dance (2019) | 7,372 | 23 |
| Space Dance Harmony (2021) | 1,242 | 5 |
| Space Dave! (2018) | 176,170 | 39 |
| Space Defender (1982) | 30,924 | 36 |
| Space Defense Grid (2022) | 850 | 9 |
| Space Demon (1980) | 20 | 1 |
| Space Depression (2021) | 150 | 3 |
| Space Docker VR (2021) | 21,591 | 85 |
| Space Dogfight (2020) | 7,028 | 17 |
| Space Doomer (2021) | 0 | 1 |
| Space Doubt (1985) | 3,572 | 5 |
| Space Dragon (2017) | 103,087 | 17 |
| Space Dragons (2022) | 356,221 | 67 |
| Space Drift Squad (2018) | 0 | 0 |
| Space Drone: Rescue Mission (2021) | 162 | 6 |
| Space Ducks: The great escape (2022) | 2,341 | 9 |
| Space Dude (1994) | 7,420,551 | 27 |
| SPACE DUDES vs ALIEN DUDES (2022) | 543 | 10 |
| Space Duel (1982) | 22,827 | 94 |
| Space Dungeon (1981) | 70,606 | 89 |
| SPACE DVRTS (2017) | 0 | 0 |
| The Space Eater (Working Title) (2022) | 0 | 0 |
| Space Eggs (1981) | 514,789 | 26 |
| Space Elite Force (2018) | 55,488 | 191 |
| Space Empires I (1993) | 443,502 | 210 |
| Space Empires II (1995) | 0 | 0 |
| Space Empires III (1997) | 2,574 | 1 |
| Space Empires IV (2000) | 88,719 | 199 |
| Space Empires V (2006) | 493,757 | 333 |
| Space Empires: Starfury (2003) | 7,435 | 17 |
