| Sid Meier's Alien Crossfire (1999) | 840,378 | 294 |
| Sid Meier's Alpha Centauri (1999) | 5,649,983 | 964 |
| Sid Meier's Antietam! (1999) | 22,098 | 5 |
| Sid Meier's Civilization VII (2025) | 69,708,255 | 9,323 |
| Sid Meier's Colonization (1994) | 2,134,252 | 833 |
| Sid Meier's Covert Action (1990) | 298,922 | 268 |
| Sid Meier's Gettysburg! (1997) | 327,112 | 59 |
| Sid Meier's Pirates! (1987) | 406,073 | 182 |
| Sid Meier's Pirates! (2004) | 18,965,946 | 4,239 |
| Sid Meier's Railroad Tycoon Deluxe (1993) | 7,997 | 14 |
| Sid Meier's Railroads! (2006) | 2,426,151 | 886 |
| Sid Meier's SimGolf (2002) | 352,923 | 214 |
| Sid Meier's Starships (2015) | 4,258,910 | 503 |
| Sid Meier’s Ace Patrol: Pacific Skies (2013) | 475,288 | 338 |
| Side Alley (2025) | 513 | 6 |
| Side B (2021) | 298,297 | 178 |
| Side by Side (1996) | 129,826,120 | 949 |
| Side by Side 2 Evoluzione (1997) | 101,730 | 50 |
| Side by Side Special (1997) | 384,811 | 262 |
| Side Effect (2022) | 10,095,732 | 167 |
| Side Pocket (1986) | 2,111,939 | 1,426 |
| Side Pocket 3 (1997) | 9,766 | 23 |
| Side42 the tavern of infinity (2025) | 0 | 0 |
| Sidecar Evolution 2024 (2024) | 2,710 | 18 |
| Sidecar Evolution 2025 (2025) | 14 | 2 |
| Sidekick AI (2026) | 0 | 0 |
| SideQuest Hunters (2025) | 2,304 | 1 |
| Sidereal Wanderer (2024) | 40 | 2 |
| SideShow (1989) | 40,518,832 | 2,850 |
| Sidestep Legends (2023) | 14,881 | 21 |
| Sideswiped (2009) | 56,653,996 | 32 |
| Sidewalk (1987) | 295,229 | 10 |
| Sidewalk Simulator (2024) | 0 | 0 |
| Sideway: New York (2011) | 559,311 | 138 |
| Sidewinder (1988) | 2,781,409 | 501 |
| Sidewize (1987) | 4,929 | 11 |
| Siebenstreich (2021) | 61,060 | 26 |
| Siege (1992) | 94,964,328 | 3,814 |
| The Siege and the Sandfox (2025) | 260,039 | 213 |
| Siege Hero (2011) | 2,423,108 | 387 |
| Siege Island (2023) | 574 | 14 |
| Siege of Avalon (2000) | 164,038 | 497 |
| The Siege of Brimir (2022) | 3,043 | 9 |
| Siege of Centauri (2019) | 329,236 | 176 |
| Siege of Dungeon (2023) | 640,923 | 140 |
| Siege of Shadows (2025) | 0 | 0 |
| Siege of Treboulain (2022) | 1,417 | 2 |
| Siege Saga (2018) | 2,342,751 | 29 |
| Siege Survival: Gloria Victis (2021) | 13,949,721 | 2,667 |
| Siege the Day (2021) | 556,743 | 125 |
| Siege Up! (2023) | 1,294,798 | 524 |
| Siege: Titan Wars (2017) | 2,407,715 | 85 |
| Siegecaster (2025) | 896 | 1 |
| Siegecraft Commander (2017) | 765,334 | 205 |
| SiegeVR (2018) | 0 | 0 |
| Sierra Championship Boxing (1983) | 6,033 | 11 |
| Sierra's 3-D Helicopter Simulator (1987) | 2,574 | 8 |
| Sift Heads Cartels (2024) | 125,718 | 56 |
| Sifting Thyme (2024) | 0 | 0 |
| Sifu (2022) | 191,623,264 | 77,910 |
| Sifu's Quest (2024) | 10 | 1 |
| Sigformation (2023) | 0 | 0 |
| Sigh of the Abyss: Shadow Bonds (2022) | 0 | 0 |
| Sigi - A Fart for Melusina (2017) | 36 | 2 |
| Sigil (2019) | 1,777,619 | 1,271 |
| Sigil of the Magi (2022) | 188,175 | 101 |
| Sigilfarer (2025) | 73,172 | 37 |
| SIGILLVM: RESONANCE (2026) | 0 | 0 |
| Sigils Of Elohim (2014) | 75,662 | 185 |
| Sigma 7 (1986) | 17,462 | 27 |
| Sigma Draconis (2021) | 12,099 | 10 |
| Sigma Harmonics (2008) | 78,920 | 26 |
| Sigma Impact (2021) | 17,718 | 8 |
| Sigma Star Saga (2005) | 467,768 | 374 |
| Sigma Theory: Global Cold War (2019) | 1,413,419 | 651 |
