| Simpocalypse (2020) | 712,918 | 117 |
| SimPoly Drive (2023) | 12 | 1 |
| The Simpsons Arcade (2009) | 14,263,873 | 2,721 |
| The Simpsons Bowling (2000) | 310,778 | 183 |
| The Simpsons Game (2007) | 213,747,975 | 10,128 |
| The Simpsons Skateboarding (2002) | 6,435,021 | 450 |
| The Simpsons Wrestling (2001) | 4,449,792 | 995 |
| The Simpsons: Bart vs. The Juggernauts (1992) | 205,272 | 93 |
| The Simpsons: Bart vs. the Space Mutants (1991) | 26,867,463 | 1,720 |
| The Simpsons: Bart vs. the World (1991) | 1,038,902 | 621 |
| The Simpsons: Bart's House of Weirdness (1991) | 518,136 | 74 |
| The Simpsons: Bart's Nightmare (1992) | 11,274,837 | 1,082 |
| The Simpsons: Bartman Meets Radioactive Man (1992) | 9,337,974 | 343 |
| The Simpsons: Cartoon Studio (1996) | 816,842 | 130 |
| The Simpsons: Minutes to Meltdown (2007) | 367,203 | 48 |
| The Simpsons: Night of the Living Treehouse of Horror (2001) | 3,037,889 | 194 |
| The Simpsons: Road Rage (2001) | 128,713,196 | 7,118 |
| The Simpsons: Tapped Out (2012) | 99,208,398 | 10,902 |
| The Simpsons: Virtual Springfield (1997) | 4,765,667 | 107 |
| SimRail - The Railway Simulator (2023) | 22,530,864 | 5,003 |
| SimRefinery (1992) | 223,925 | 8 |
| The Sims (2000) | 1,833,455,765 | 53,511 |
| The Sims 2 (2004) | 557,296,848 | 82,821 |
| The Sims 2: Apartment Pets (2008) | 166,989 | 421 |
| The Sims 2: Castaway (2007) | 13,052,524 | 1,836 |
| The Sims 2: Double Deluxe (2008) | 122,677 | 39 |
| The Sims 3 (2009) | 2,104,675,978 | 151,447 |
| The Sims 4 (2014) | 22,837,271,585 | 1,063,914 |
| The Sims Bustin' Out (2003) | 14,231,721 | 4,424 |
| The Sims Carnival: Snap City (2008) | 13,640 | 11 |
| The Sims Castaway Stories (2008) | 8,251,776 | 1,026 |
| The Sims FreePlay (2011) | 196,519,752 | 17,163 |
| The Sims Life Stories (2007) | 8,095,903 | 1,006 |
| The Sims Medieval (2011) | 44,466,638 | 6,184 |
| The Sims Mobile (2018) | 67,651,181 | 7,633 |
| The Sims Online (2002) | 11,210,781 | 499 |
| The Sims Pet Stories (2007) | 462,827 | 450 |
| The Sims Social (2011) | 1,928,241 | 164 |
| SimSafari (1998) | 288,054 | 29 |
| Simson Tuningwerkstatt 3D (2018) | 202 | 1 |
| SimTower (1994) | 1,780,118 | 339 |
| SimTown (1995) | 282,293 | 49 |
| SimTunes (1996) | 13,237 | 12 |
| Simulacra (2017) | 152,770,434 | 3,268 |
| SIMULACRA 2 (2019) | 34,518,261 | 1,669 |
| SIMULACRA 3 (2022) | 324 | 18 |
| SIMULACRA: Pipe Dreams (2018) | 6,260,616 | 324 |
| The Simulacrum (2023) | 3,043,389 | 507 |
| Simulakros (2024) | 120,357 | 62 |
| Simulation Pro Yakyuu (1995) | 2,404 | 22 |
| Simulation RPG Tsukuru (1998) | 969 | 5 |
| Simulation Training Room: Massacre (2024) | 33 | 2 |
| Simulator of Countries (2024) | 9,499 | 23 |
| Simulator of Ukraine 1991 (2024) | 15,844 | 14 |
| Simulator: Parking Lot (2024) | 9,406 | 10 |
| Simulcra (1990) | 10,251 | 30 |
| Simultaneous Control (2022) | 52 | 3 |
| Simutrans (1999) | 775,389 | 2,363 |
| SiN (1998) | 45,148,993 | 3,312 |
| Sin and Punishment (2000) | 3,639,530 | 1,717 |
| The Sin Collector: Repentless (2021) | 28,667 | 18 |
| SiN Episodes (2006) | 2,415,235 | 781 |
| Sin Slayers (2019) | 486,389 | 339 |
| Sin Slayers: Reign of The 8th (2024) | 61,269 | 83 |
| Sin'geom-ui Jeonseol - Dream Traveler Part 1 (1987) | 3,962 | 14 |
| Sinbad and the Throne of the Falcon (1987) | 40,018 | 25 |
| Sinderfury (2024) | 105 | 6 |
| Sine Mora (2012) | 4,330,192 | 2,264 |
| Sing Party (2012) | 476,532 | 153 |
| Singaria (2019) | 7,548 | 7 |
| The Singing Saw Simulator (2024) | 11 | 3 |
| Singled Out (2019) | 43,579,710 | 48 |
| SingStar (2004) | 12,935 | 18 |
| SingStar (2007) | 102,551 | 25 |
| SingStar '80s (2007) | 149,489 | 32 |
