| Slipstream 5000 (1995) | 296,862 | 90 |
| Sliptime Sleuth (2020) | 738 | 6 |
| Slipways (2021) | 1,337,052 | 854 |
| Slither (1982) | 80,645,723 | 1,517 |
| Slither Link Plus (2025) | 0 | 0 |
| Slither Loop (2020) | 435 | 3 |
| Slither.io (2016) | 7,459,859,864 | 61,929 |
| Slitherise (2025) | 0 | 0 |
| Slitterhead (2024) | 178 | 2 |
| Slizer Battle Management System (2018) | 2,098 | 5 |
| Slo's Home (2024) | 1,171 | 2 |
| Slobbish Dragon Princess (2021) | 33,064 | 130 |
| Slobbish Dragon Princess 2 (2021) | 6,454 | 32 |
| Slopecrashers (2023) | 150,336 | 212 |
| Sloppy Fields (2025) | 0 | 0 |
| Sloppy Forgeries (2019) | 157 | 2 |
| Slordax: The Unknown Enemy (1991) | 5,210 | 15 |
| The Slormancer (2021) | 2,548,059 | 2,241 |
| Slot & Dungeons (2025) | 136,628 | 192 |
| Slot Car Rivals (2016) | 36,694 | 38 |
| Slot Gambler (1995) | 238 | 3 |
| Slot Machine (1979) | 76,891,655 | 4,634 |
| Slot or Not (2026) | 51,226 | 21 |
| Slot Racers (1978) | 67,459 | 71 |
| Slot Shots Pinball Collection (2022) | 15,195 | 91 |
| Sloth Tales (2020) | 85 | 5 |
| Sloth: Heart to Heart (2019) | 1,320 | 5 |
| The Slothgate Experiment (2022) | 53,767 | 16 |
| Slotomania (2011) | 3,504,396 | 3,170 |
| Slotz Racer (2009) | 76,386 | 12 |
| Slow Down, Bull (2015) | 11,084 | 37 |
| Sludge Fighters (2021) | 23 | 1 |
| Sludge Life (2020) | 2,991,878 | 1,154 |
| SLUDGE LIFE 2 (2023) | 961,995 | 266 |
| Slum Dweller (2025) | 1,523 | 6 |
| Slumberer's Universe (2025) | 127 | 9 |
| Sly 2: Band of Thieves (2004) | 49,880,615 | 36,935 |
| Sly 3: Honor Among Thieves (2005) | 38,345,896 | 19,437 |
| Sly Cooper and the Thievius Raccoonus (2002) | 96,192,780 | 32,870 |
| Sly Cooper: Thieves in Time (2013) | 111,296,505 | 16,024 |
| Sly Slime (2020) | 1,667 | 7 |
| Sly Spy (1989) | 549,400 | 460 |
| Slyder (2002) | 15,230 | 8 |
| Slyders (2025) | 46,613 | 132 |
| Slydris (2012) | 9,360 | 13 |
| SM Word (2007) | 53 | 2 |
| Smack Monkey (2025) | 0 | 0 |
| Smack Studio (2024) | 285,990 | 78 |
| Smack Wacker (1986) | 0 | 0 |
| Small Arms (2006) | 3,225,188 | 272 |
| Small Bird Forest (2022) | 0 | 0 |
| Small Cell (2023) | 2,356 | 12 |
| Small Dragon Big Appetite (2024) | 81 | 6 |
| Small Kingdoms (2025) | 1,086,663 | 7 |
| Small People Defense (2023) | 4,521 | 11 |
| Small Radios Big Televisions (2016) | 246,867 | 226 |
| Small Saga (2023) | 775,206 | 1,018 |
| Small Sister (2018) | 26,673,690 | 41 |
| Small Soldiers (1998) | 11,409,450 | 1,116 |
| Small Soldiers: Squad Commander (1998) | 207,055 | 136 |
| Small Spaces (2025) | 419,063 | 165 |
| Small Town Terror: Galdor's Bluff (2015) | 37,807 | 87 |
| Small Town Terror: Livingston (2012) | 40,664 | 66 |
| Small Town Terror: Pilgrim's Hook (2013) | 43,274 | 157 |
| Small Wars: Mohicans (2024) | 4,765 | 5 |
| Small World (2013) | 17,707,221 | 1,671 |
| Smalland: Survive the Wilds (2023) | 16,812,816 | 14,220 |
| Smalles (2021) | 13,146,275 | 1,273 |
| SmallWorlds (2008) | 3,126,990 | 155 |
| SmallZ (2023) | 229,491 | 10 |
| Smart As... (2012) | 1,030,224 | 115 |
| Smart Ball (1991) | 8,526,542 | 477 |
| Smart Bomb (2005) | 17,417 | 39 |
| Smart Boy's Gameroom (2007) | 12,216 | 16 |
| Smart City Plan (2020) | 4,414,126 | 134 |
