| Scarygirl (2012) | 431,236 | 181 |
| Scarytales: All Hail King Mongo (2019) | 4,289 | 27 |
| Scatter Slots (2014) | 1,143,742 | 129 |
| Scavengers (2021) | 285,977,918 | 6,977 |
| Sceal: An Irish Folklore Adventure (2016) | 2,569 | 6 |
| Scelestum (2022) | 1,916 | 3 |
| Scenario (1992) | 0 | 0 |
| Scene Investigators (2023) | 6,012,310 | 1,213 |
| Scene of the Crime (2010) | 636,760 | 62 |
| Scene of the Crime: Golden Doll (2010) | 320,676 | 4 |
| Scepter of Goth (1978) | 1,237 | 3 |
| Sceptre of Bagdad (1987) | 16,881 | 16 |
| SCHAR: Blue Shield Alliance (2015) | 6,009 | 21 |
| Scheming Through The Zombie Apocalypse: The Beginning (2018) | 1,804,056 | 427 |
| Schizm: Mysterious Journey (2001) | 2,722,091 | 907 |
| Schlag den Star - Das Spiel (2017) | 540 | 17 |
| Schmeiser Robo (1993) | 37,501 | 77 |
| Scholar of the Arcane Arts (2022) | 17,126 | 67 |
| School Girl Strikers: Twinkle Melodies (2017) | 103,334 | 51 |
| School Girl/Zombie Hunter (2017) | 2,194,844 | 2,656 |
| School of Dragons (2014) | 115,514,738 | 7,173 |
| School of Magic (2022) | 365,648 | 149 |
| School Panic (1987) | 378 | 8 |
| School Paranormal Laboratory (2024) | 2,030 | 16 |
| School Rumble: Neru Musume wa Sodatsu (2005) | 0 | 0 |
| School Tycoon (2004) | 920,704 | 367 |
| School Years (2019) | 19,932,459 | 842 |
| Schoolgirl Strikers (2014) | 6,945,684 | 2,221 |
| Schrodinger's Catgirl (2022) | 390 | 4 |
| Schwarzerblitz (2020) | 11,560 | 250 |
| Sci-Fantasy Defence (2022) | 3,083 | 6 |
| Science Girls (2022) | 9,960 | 36 |
| Science Simulator (2022) | 780,281 | 278 |
| Scientific Shutdown (2021) | 34 | 1 |
| Scientifically Accurate Dinosaur Mating Simulator 2021 (2021) | 24 | 2 |
| SciFly: Dogfight (2008) | 0 | 0 |
| SciGirl: The Internship (2021) | 419,231 | 10 |
| Scion (1984) | 949,694 | 475 |
| Sciware Defense (2023) | 0 | 0 |
| Sclash (2023) | 1,354,115 | 308 |
| Sclender (2022) | 0 | 0 |
| Scooby Doo 2 - Monsters Unleashed (2004) | 2,053,358 | 163 |
| Scooby Doo 2 Monsters Unleashed (2004) | 134,642 | 7 |
| Scooby Doo! Case File #3: Frights, Camera, Mystery! (2006) | 480,138 | 19 |
| Scooby Doo: The Motion Picture (2001) | 2,102 | 16 |
| Scooby-Doo (1986) | 50,239,825 | 448 |
| Scooby-Doo (2002) | 106,425 | 10 |
| Scooby-Doo and Scrappy-Doo (1991) | 121,135 | 88 |
| Scooby-Doo and the Cyber Chase (2001) | 7,893,234 | 1,720 |
| Scooby-Doo Case File #2: The Scary Stone Dragon (2003) | 267,519 | 32 |
| Scooby-Doo in the Castle Mystery (1986) | 398 | 2 |
| Scooby-Doo Mystery (1995) | 42,753,835 | 1,326 |
| Scooby-Doo Mystery Cases (2018) | 299,007 | 146 |
| Scooby-Doo! and the Spooky Swamp (2010) | 45,309,639 | 1,473 |
| Scooby-Doo! Classic Creep Capers (2000) | 6,362,811 | 481 |
| Scooby-Doo! First Frights (2009) | 80,979,145 | 4,002 |
| Scooby-Doo! Jinx at the Sphinx (2000) | 4,897,089 | 27 |
| Scooby-Doo! Mystery Adventures (2000) | 21,433 | 25 |
| Scooby-Doo! Mystery Mayhem (2003) | 24,988,052 | 1,635 |
| Scooby-Doo! Mystery of the Fun Park Phantom (1999) | 364,706 | 15 |
| Scooby-Doo! Night of 100 Frights (2002) | 8,131,190 | 3,795 |
| Scooby-Doo! Phantom of the Knight (2000) | 911,158 | 30 |
| Scooby-Doo! Showdown in Ghost Town (2000) | 848,477 | 60 |
| Scooby-Doo! Unmasked (2005) | 6,606,554 | 1,530 |
| Scooby-Doo! Who's Watching Who? (2006) | 1,409,612 | 183 |
| Scooby-Doo: Jinx at the Sphinx (2001) | 575,913 | 44 |
| Scooby-Doo: Phantom of the Knight (2000) | 62,128 | 70 |
| Scoot Scoot (2016) | 2,781,868 | 42 |
| Scooter Shooter (1985) | 32,951 | 30 |
| Scooter War3z (2006) | 18,758 | 15 |
| Scorched 3D (2001) | 84,675 | 25 |
| Scorched Planet (1996) | 15,093 | 9 |
| Scorched Tanks (1993) | 16,344 | 16 |
| Scorcher (1996) | 784,444 | 267 |
| The Scorchfarer (2022) | 547 | 18 |
