| Sangokushi V (1995) | 1,410,538 | 455 |
| SANGRA (2026) | 24 | 1 |
| Sanguine Sanctum (2018) | 97,427 | 65 |
| Sanguis: Veil of the Forgotten (2026) | 0 | 0 |
| Sanguivore: Twenty Below (2023) | 37,222 | 29 |
| Sanguo Warriors (2018) | 7,386 | 11 |
| Sani Yang's Laboratory (2025) | 0 | 0 |
| Sanitarium (1998) | 6,438,627 | 2,942 |
| Sanity Loops (2025) | 0 | 0 |
| Sanity of Morris (2020) | 198,491 | 339 |
| Sanity: Aiken's Artifact (2000) | 99,027 | 111 |
| Sankaku Renai: Love Triangle Trouble (2019) | 386,927 | 1,005 |
| Sankyo Fever! Fever! (1994) | 20,408 | 36 |
| SANRI (2023) | 834,041 | 278 |
| Sanrio Characters Picross (2018) | 7,453 | 22 |
| Sanrio Cup: Pon Pon Volley (1992) | 7,846 | 29 |
| Sanrio Timenet (1998) | 8,974 | 33 |
| Sansara Naga (1990) | 398,620 | 13 |
| Sansara Naga 1x2 (2001) | 50,976 | 23 |
| Sansara Naga 2 (1994) | 362,697 | 318 |
| Santa Balls (2001) | 589,103 | 28 |
| Santa Claus in Trouble (2002) | 1,773,962 | 762 |
| Santa Claus Jr. Advance (2002) | 35,562 | 84 |
| Santa Claus no Takarabako (1987) | 15,023 | 56 |
| Santa Claus Saves the Earth (2002) | 1,346,449 | 214 |
| Santa Fe Mysteries: Sacred Ground (1997) | 10,453 | 20 |
| Santa Girls (2019) | 15,481,094 | 138 |
| Santa Monica Paradise (2020) | 0 | 0 |
| Santa Paravia en Fiumaccio (1978) | 4,005 | 11 |
| Santa Ride! (2004) | 54,983 | 38 |
| Santa Rockstar (2016) | 421,234 | 132 |
| Santa Slides to Town (2024) | 0 | 0 |
| Santa Tracker (2018) | 1,485,999 | 443 |
| Santa's Christmas Solitaire (2016) | 342,535 | 28 |
| Santa's Holiday (2019) | 56 | 1 |
| Santa's Secret Valley (1995) | 1,206 | 1 |
| Santa's Special Delivery (2016) | 36,401 | 23 |
| Santa's Xmas Adventure (2017) | 19,792 | 145 |
| SantaFly (2002) | 344 | 3 |
| Santaower Defense (2024) | 0 | 1 |
| Santas Basement (2023) | 150,006 | 261 |
| Santo Island Incident (2022) | 9,870 | 51 |
| Sanvein (2000) | 127,254 | 94 |
| Sanxion (1986) | 65,095 | 63 |
| SANYA (2022) | 617,108 | 162 |
| Sanyo Pachinko Paradise (1999) | 32,307 | 69 |
| Sanyo Pachinko Paradise 3 (2000) | 807 | 4 |
| Sanyo Pachinko Paradise 5 (2001) | 1,556 | 3 |
| Sanyo Pachinko Paradise 6 (2001) | 653,094 | 11 |
| Sanyo Pachinko Paradise 8 (2003) | 134,984 | 57 |
| Sanyo Pachinko Paradise 9 (2003) | 11,888 | 35 |
| Sanyo Pachinko Paradise DX (2001) | 40,135 | 26 |
| Sapiens (2022) | 8,265,617 | 2,489 |
| Sapiens Craft (2023) | 369 | 3 |
| Sapiens Craft Puzzle (2025) | 0 | 0 |
| Sapiens League (2023) | 558 | 1 |
| The Sapling (2019) | 2,792,787 | 374 |
| Sapo 3D (2025) | 1,608 | 15 |
| Sapper - Defuse The Bomb Simulator (2021) | 509,866 | 199 |
| Sapphire Safari (2025) | 13 | 1 |
| Saracen (1987) | 6,207 | 21 |
| Sarah: Keeper of the Unicorn (2007) | 25,476 | 49 |
| Sarakon (1990) | 1,570 | 11 |
| Sarawak (2021) | 462,722 | 308 |
| Sarcophaser (1988) | 5,365 | 4 |
| Sarge (1985) | 1,419,526 | 259 |
| Sargon 4 (1988) | 84,285 | 12 |
| Sargon 5: World Class Chess (1991) | 149 | 3 |
| Sargon II (1979) | 4,222 | 9 |
| Sargon III (1983) | 2,542 | 16 |
| Sarissa and the Legendary Sword (2022) | 17 | 3 |
| Saru! Get You! Million Monkeys (2006) | 175,081 | 223 |
| Saru! Get You! SaruSaru Big Mission (2007) | 225,522 | 124 |
| SAS Anti-Terror Force (2006) | 100,779 | 22 |
| SAS Combat Simulator (1989) | 16,588 | 44 |
