| Santa Claus Saves the Earth (2002) | 1,346,438 | 213 |
| Santa Fe Mysteries: Sacred Ground (1997) | 10,453 | 20 |
| Santa Girls (2019) | 15,235,067 | 138 |
| Santa Monica Paradise (2020) | 0 | 0 |
| Santa Paravia en Fiumaccio (1978) | 4,005 | 11 |
| Santa Ride! (2004) | 54,979 | 38 |
| Santa Rockstar (2016) | 421,230 | 132 |
| Santa Tracker (2018) | 1,484,260 | 442 |
| Santa's Christmas Solitaire (2016) | 342,535 | 28 |
| Santa's Holiday (2019) | 55 | 1 |
| Santa's Secret Valley (1995) | 1,206 | 1 |
| Santa's Special Delivery (2016) | 36,401 | 23 |
| Santa's Xmas Adventure (2017) | 19,792 | 145 |
| SantaFly (2002) | 344 | 3 |
| Santaower Defense (2024) | 0 | 1 |
| Santas Basement (2023) | 150,006 | 261 |
| Santo Island Incident (2022) | 9,869 | 50 |
| Sanvein (2000) | 127,254 | 94 |
| Sanxion (1986) | 65,095 | 63 |
| SANYA (2022) | 608,813 | 161 |
| Sanyo Pachinko Paradise (1999) | 32,307 | 69 |
| Sanyo Pachinko Paradise 3 (2000) | 490 | 3 |
| Sanyo Pachinko Paradise 5 (2001) | 1,556 | 3 |
| Sanyo Pachinko Paradise 6 (2001) | 651,809 | 10 |
| Sanyo Pachinko Paradise 8 (2003) | 134,959 | 52 |
| Sanyo Pachinko Paradise 9 (2003) | 11,888 | 35 |
| Sanyo Pachinko Paradise DX (2001) | 40,135 | 26 |
| Sapiens (2022) | 8,264,557 | 2,466 |
| Sapiens Craft (2023) | 361 | 3 |
| Sapiens Craft Puzzle (2025) | 0 | 0 |
| Sapiens League (2023) | 558 | 1 |
| The Sapling (2019) | 2,777,200 | 370 |
| Sapo 3D (2025) | 1,608 | 15 |
| Sapper - Defuse The Bomb Simulator (2021) | 509,866 | 199 |
| Saracen (1987) | 6,069 | 18 |
| Sarah: Keeper of the Unicorn (2007) | 25,476 | 49 |
| Sarakon (1990) | 1,567 | 11 |
| Sarawak (2021) | 461,401 | 304 |
| Sarcophaser (1988) | 5,365 | 4 |
| Sarge (1985) | 1,383,613 | 253 |
| Sargon 4 (1988) | 84,285 | 12 |
| Sargon 5: World Class Chess (1991) | 149 | 3 |
| Sargon II (1979) | 4,222 | 9 |
| Sargon III (1983) | 2,542 | 16 |
| Sarissa and the Legendary Sword (2022) | 17 | 3 |
| Saru! Get You! Million Monkeys (2006) | 175,052 | 223 |
| Saru! Get You! SaruSaru Big Mission (2007) | 225,517 | 124 |
| SAS Anti-Terror Force (2006) | 100,779 | 22 |
| SAS Combat Simulator (1989) | 16,588 | 44 |
| SAS: Secure Tomorrow (2008) | 714,137 | 392 |
| Sasa (1984) | 2,995,691 | 334 |
| Sass VS Fash: Girlballs of Steel (2023) | 2,890 | 14 |
| Sassy Cybergirl (2023) | 0 | 0 |
| Sassy Girl (2024) | 209,197 | 42 |
| Sasuke vs Commander (1980) | 75,183 | 88 |
| SAT.1 Bingo (1992) | 1,283 | 6 |
| Satama Puzzle (2022) | 73 | 2 |
| Satan (1989) | 94,069 | 46 |
| Satan's Hollow (1982) | 1,477,565 | 189 |
| Satanislas (2024) | 177 | 4 |
| SATAZIUS (2011) | 154,805 | 170 |
| Satellite Reign (2015) | 3,627,036 | 2,232 |
| Satisfactory (2024) | 810,954,025 | 259,167 |
| Satisfrustration (2024) | 1 | 2 |
| Satomi Hakkenden (1989) | 3,497 | 19 |
| satori (2025) | 1,257 | 7 |
| Satoru Nakajima F-1 Hero GB World Championship '91 (1991) | 6,069 | 1 |
| Saturated Outer Space (2022) | 21,462 | 92 |
| Saturday Morning RPG (2012) | 1,961,528 | 833 |
| Saturday Night Slam Masters (1993) | 5,220,480 | 2,226 |
| Saturday of Piercing Screams (2019) | 1,443 | 8 |
| Saturn Bomberman (1996) | 2,315,732 | 1,178 |
| Saturn Bomberman Fight!! (1997) | 1,345,157 | 200 |
| Saturnalia (2022) | 811,400 | 737 |
| SATUS (2023) | 33,806,887 | 2,764 |
