| Santa Monica Paradise (2020) | 0 | 0 |
| Santa Paravia en Fiumaccio (1978) | 0 | 0 |
| Santa Ride! (2004) | 0 | 0 |
| Santa Rockstar (2016) | 0 | 0 |
| Santa Tracker (2018) | 1,461,482 | 436 |
| Santa's Christmas Solitaire (2016) | 342,535 | 28 |
| Santa's Secret Valley (1995) | 1,206 | 1 |
| Santa's Special Delivery (2016) | 0 | 0 |
| Santa's Xmas Adventure (2017) | 19,788 | 144 |
| SantaFly (2002) | 344 | 3 |
| Santaower Defense (2024) | 0 | 1 |
| Santas Basement (2023) | 150,006 | 261 |
| Santo Island Incident (2022) | 9,869 | 50 |
| Sanvein (2000) | 127,196 | 91 |
| Sanxion (1986) | 64,859 | 62 |
| SANYA (2022) | 0 | 0 |
| Sanyo Pachinko Paradise (1999) | 0 | 0 |
| Sanyo Pachinko Paradise 3 (2000) | 490 | 3 |
| Sanyo Pachinko Paradise 5 (2001) | 1,556 | 3 |
| Sanyo Pachinko Paradise 6 (2001) | 0 | 0 |
| Sanyo Pachinko Paradise 8 (2003) | 116,770 | 47 |
| Sanyo Pachinko Paradise 9 (2003) | 11,888 | 35 |
| Sanyo Pachinko Paradise DX (2001) | 39,495 | 25 |
| Sapiens (2022) | 8,234,243 | 2,428 |
| Sapiens Craft (2023) | 328 | 3 |
| Sapiens League (2023) | 0 | 0 |
| The Sapling (2019) | 2,716,974 | 364 |
| Sapo 3D (2025) | 1,227 | 13 |
| Sapper - Defuse The Bomb Simulator (2021) | 509,866 | 198 |
| Saracen (1987) | 0 | 0 |
| Sarah: Keeper of the Unicorn (2007) | 25,476 | 49 |
| Sarakon (1990) | 0 | 0 |
| Sarawak (2021) | 363,254 | 287 |
| Sarcophaser (1988) | 0 | 0 |
| Sarge (1985) | 846,881 | 233 |
| Sargon 4 (1988) | 84,279 | 12 |
| Sargon 5: World Class Chess (1991) | 149 | 3 |
| Sargon II (1979) | 0 | 0 |
| Sargon III (1983) | 2,526 | 15 |
| Sarissa and the Legendary Sword (2022) | 17 | 3 |
| Saru! Get You! Million Monkeys (2006) | 174,637 | 214 |
| Saru! Get You! SaruSaru Big Mission (2007) | 224,751 | 123 |
| SAS Anti-Terror Force (2006) | 0 | 0 |
| SAS Combat Simulator (1989) | 0 | 0 |
| SAS: Secure Tomorrow (2008) | 713,219 | 379 |
| Sasa (1984) | 2,850,549 | 319 |
| Sass VS Fash: Girlballs of Steel (2023) | 2,890 | 14 |
| Sassy Cybergirl (2023) | 0 | 0 |
| Sassy Girl (2024) | 0 | 0 |
| Sasuke vs Commander (1980) | 74,397 | 85 |
| SAT.1 Bingo (1992) | 1,283 | 6 |
| Satama Puzzle (2022) | 73 | 2 |
| Satan (1989) | 94,068 | 46 |
| Satan's Hollow (1982) | 0 | 0 |
| Satanislas (2024) | 177 | 4 |
| SATAZIUS (2011) | 154,684 | 169 |
| Satellite Reign (2015) | 3,625,976 | 2,216 |
| Satisfactory (2024) | 773,357,818 | 246,089 |
| Satisfrustration (2024) | 0 | 0 |
| Satomi Hakkenden (1989) | 0 | 0 |
| satori (2025) | 1,238 | 4 |
| Satoru Nakajima F-1 Hero GB World Championship '91 (1991) | 6,069 | 1 |
| Saturated Outer Space (2022) | 0 | 0 |
| Saturday Morning RPG (2012) | 1,960,321 | 828 |
| Saturday Night Slam Masters (1993) | 5,184,425 | 2,172 |
| Saturday of Piercing Screams (2019) | 1,443 | 8 |
| Saturn Bomberman (1996) | 2,302,757 | 1,141 |
| Saturn Bomberman Fight!! (1997) | 1,342,005 | 186 |
| Saturnalia (2022) | 803,092 | 722 |
| SATUS (2023) | 33,381,057 | 2,671 |
| SauceLore (2025) | 0 | 0 |
| Saucer Attack! (1984) | 235,028 | 29 |
| Sauna of the DEAD (2024) | 8,126 | 35 |
| Sauna Simulator (2024) | 191,866 | 5 |
| Saurian (2017) | 0 | 0 |
