| Space Bunnies Must Die! (1998) | 28,911 | 26 |
| Space Bunny Explorers (2022) | 63 | 5 |
| Space Bust-a-Move (2008) | 103,235 | 91 |
| Space Castle (2020) | 25,490 | 36 |
| Space Cats (2024) | 910,663 | 195 |
| Space Cats Tactics (2022) | 111,687 | 104 |
| Space Cavern (1982) | 49,986 | 48 |
| Space Channel 5 (1999) | 6,604,172 | 1,242 |
| Space Channel 5 VR: Kinda Funky News Flash! (2020) | 1,667,026 | 231 |
| Space Channel 5: Part 2 (2002) | 8,279,428 | 1,664 |
| Space Channel 5: Ulala's Cosmic Attack (2003) | 67,247 | 38 |
| Space Cheese Defenders (2024) | 0 | 1 |
| Space Cheetah Hyper Runner (2022) | 109 | 3 |
| Space Chef (2025) | 32 | 1 |
| Space Chimps (2008) | 3,605,959 | 156 |
| Space Choice: Data Analyzer (2021) | 1,491 | 20 |
| Space City - Build Your Empire (2022) | 53 | 2 |
| Space Clash: The Last Frontier (1999) | 17,600 | 45 |
| Space Climber (2019) | 0 | 0 |
| Space Codex (2016) | 3,273 | 7 |
| Space Colonizer (2022) | 4,953 | 10 |
| Space Colonizers Idle Clicker (2018) | 2,443 | 12 |
| Space Colony (2003) | 7,252,423 | 1,948 |
| Space Combat (2004) | 1,980,884 | 371 |
| Space Commander 9 (2018) | 0 | 0 |
| Space Commander: War and Trade (2020) | 416,698 | 482 |
| Space Company Simulator (2019) | 213,382 | 72 |
| Space Cowboy (2018) | 11,065,622 | 296 |
| Space Cowboys - Riders of the Storm (2023) | 492 | 3 |
| Space Cows (2019) | 1,310,462 | 107 |
| Space Crab VS (2024) | 4,110 | 9 |
| SPACE Craft (2020) | 3,967,190 | 627 |
| Space Crafting (2022) | 749 | 5 |
| Space Crash Simulator (2025) | 0 | 0 |
| Space Crew (2020) | 5,281,696 | 2,656 |
| Space Crisis (2020) | 1,714,709 | 63 |
| Space Cruise (2019) | 4,984 | 3 |
| Space Crusade (1992) | 677,020 | 249 |
| Space Crusade: The Voyage Beyond (1992) | 2,947 | 2 |
| Space Crusaders (2022) | 23,173 | 14 |
| Space Cube Racers (2020) | 0 | 0 |
| Space Cube Tower Defense (2021) | 0 | 0 |
| Space Cycle (2024) | 628 | 7 |
| Space Dance (2019) | 2,564,199 | 23 |
| Space Dance Harmony (2021) | 2,271 | 8 |
| Space Dave! (2018) | 13,363 | 30 |
| Space Defender (1982) | 64,374 | 47 |
| Space Defense Grid (2022) | 850 | 9 |
| Space Demon (1980) | 6,956 | 10 |
| Space Depression (2021) | 1,442 | 4 |
| Space Detective: The Case of the Rebel Robot (2023) | 0 | 0 |
| Space Diva (2026) | 0 | 0 |
| Space Docker VR (2021) | 28,192 | 96 |
| Space Dogfight (2020) | 67,303 | 22 |
| SPACE DOGO (2023) | 0 | 0 |
| Space Doomer (2021) | 22 | 2 |
| Space Doubt (1985) | 3,552 | 4 |
| Space Dragon (2017) | 7,213 | 28 |
| Space Dragons (2022) | 483,666 | 80 |
| Space Drift Squad (2018) | 0 | 0 |
| Space Drilling Station (2025) | 79,083 | 64 |
| Space Drone: Rescue Mission (2021) | 219 | 7 |
| Space Drop (2024) | 55,016 | 28 |
| Space Duck: Escape (2024) | 92 | 2 |
| Space Ducks: The great escape (2022) | 2,341 | 9 |
| Space Dude (1994) | 7,404,635 | 23 |
| SPACE DUDES vs ALIEN DUDES (2022) | 580 | 11 |
| Space Duel (1982) | 29,396 | 101 |
| Space Dungeon (1981) | 78,855 | 101 |
| SPACE DVRTS (2017) | 0 | 0 |
| The Space Eater (Working Title) (2022) | 0 | 0 |
| Space Eggs (1981) | 554,554 | 29 |
| Space Elite Force (2018) | 51,890 | 183 |
| Space Empires I (1993) | 1,215,341 | 576 |
| Space Empires II (1995) | 0 | 0 |
